Results 11 to 20 of about 882,207 (290)

Reversible 2'-OH acylation enhances RNA stability. [PDF]

Nat Chem, 2023
Abstract Stabilization of RNAs for storage, transport, and biological application remains a serious challenge, particularly for larger RNAs that are not accessible by chemical synthesis. Here, we present reversible 2’-OH acylation as a general strategy to preserve RNA of any length or origin. High-yield polyacylation of 2’-hydroxyls (“cloaking”)
Fang L, Xiao L, Jun YW, Onishi Y, Kool ET.   +4 more
europepmc   +3 more sources

Arginine multivalency stabilizes protein/RNA condensates [PDF]

Protein Science, 2021
Abstract Biomolecular condensates assembled through liquid–liquid phase separation (LLPS) of proteins and RNAs are currently recognized to play an important role in cellular organization. Their assembly depends on the formation of a network of transient, multivalent interactions between flexible scaffold biomolecules.
Matteo Paloni, Giovanni Bussi, Alessandro Barducci   +2 more
openaire   +3 more sources

Effects of Nanoparticles on Double-Stranded RNA Stability in Corn Soil [PDF]

, 2018
Double-stranded RNA (dsRNA) can potentially be used as a pesticide because these molecules trigger an immune response called RNA interference (RNAi). If the expression of essential genes matching the dsRNA sequence are silenced, then the pest dies.
Reyanldo, Miriam, Cooper, Anastasia, Song, Huifang, Yu, Zhitao, Zhang, Hao, Silver, Kristopher, Zhang, Jianzhen, Zhu, Kun Yan   +7 more
core   +5 more sources

Characterizing RNA stability genome-wide through combined analysis of PRO-seq and RNA-seq data

BMC Biology, 2021
Background The concentrations of distinct types of RNA in cells result from a dynamic equilibrium between RNA synthesis and decay. Despite the critical importance of RNA decay rates, current approaches for measuring them are generally labor-intensive ...
Amit Blumberg, Yixin Zhao, Yi-Fei Huang, Noah Dukler, Edward J. Rice, Alexandra G. Chivu, Katie Krumholz, Charles G. Danko, Adam Siepel   +8 more
doaj   +1 more source

Predicting 3D structure and stability of RNA pseudoknots in monovalent and divalent ion solutions. [PDF]

PLoS Computational Biology, 2018
RNA pseudoknots are a kind of minimal RNA tertiary structural motifs, and their three-dimensional (3D) structures and stability play essential roles in a variety of biological functions.
Ya-Zhou Shi, Lei Jin, Chen-Jie Feng, Ya-Lan Tan, Zhi-Jie Tan   +4 more
doaj   +1 more source

Repression of PUM1-mediated mRNA decay activates translesion synthesis after DNA damage

Molecular & Cellular Oncology, 2020
Biological roles of Pumilio1 (PUM1) in ubiquitous cells remain unclear. Here we identify 48 degrading target mRNAs by combined analysis of transcriptome-wide mRNA stabilities and the binding of mRNAs.
Toshimichi Yamada, Xiaoning Sun, Nobuyoshi Akimitsu   +2 more
doaj   +1 more source

Stability of SARS-CoV-2 RNA in Nonsupplemented Saliva

Emerging Infectious Diseases, 2021
The expense of saliva collection devices designed to stabilize severe acute respiratory syndrome coronavirus 2 RNA is prohibitive to mass testing. However, virus RNA in nonsupplemented saliva is stable for extended periods and at elevated temperatures ...
Isabel M. Ott, Madison S. Strine, Anne E. Watkins, Maikel Boot, Chaney C. Kalinich, Christina A. Harden, Chantal B.F. Vogels, Arnau Casanovas-Massana, Adam J. Moore, M. Catherine Muenker, Maura Nakahata, Maria Tokuyama, Allison Nelson, John Fournier, Santos Bermejo, Melissa Campbell, Rupak Datta, Charles S. Dela Cruz, Shelli F. Farhadian, Albert I. Ko, Akiko Iwasaki, Nathan D. Grubaugh, Craig B. Wilen, Anne L. Wyllie   +23 more
doaj   +1 more source

Borate Minerals and RNA Stability [PDF]

Polymers, 2010
The abiotic origin of genetic polymers faces two major problems: a prebiotically plausible polymerization mechanism and the maintenance of their polymerized state outside a cellular environment. The stabilizing action of borate on ribose having been reported, we have explored the possibility that borate minerals stabilize RNA.
Cristina Cossetti, Claudia Crestini, Raffaele Saladino, DI MAURO, Ernesto   +3 more
openaire   +5 more sources

Melting of Branched RNA Molecules [PDF]

, 2007
Stability of the branching structure of an RNA molecule is an important condition for its function. In this letter we show that the melting thermodynamics of RNA molecules is very sensitive to their branching geometry for the case of a molecule whose ...
B. Alberts, P. B. Moore, Ralf Bundschuh, Robijn Bruinsma   +3 more
core   +2 more sources

Riboswitch control of bacterial RNA stability. [PDF]

Mol Microbiol, 2021
AbstractAlthough riboswitches have long been known to regulate translation initiation and transcription termination, a growing body of evidence indicates that they can also control bacterial RNA lifetimes by acting directly to hasten or impede RNA degradation. Ligand binding to the aptamer domain of a riboswitch can accelerate RNA decay by triggering a
Richards J, Belasco JG.
europepmc   +4 more sources