RNA Stability: A Review of the Role of Structural Features and Environmental Conditions [PDF]
MoleculesThe stability of RNA is a critical factor in determining its functionality and degradation in the cell. In recent years, it has been shown that the stability of RNA depends on a complex interaction of external and internal factors.
Igor V. Kornienko +4 more
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RNA stability is regulated by both RNA polyadenylation and ATP levels, linking RNA and energy metabolisms in Escherichia coli [PDF]
mBioThe post-transcriptional process of RNA polyadenylation sits at the crossroads of energy metabolism and RNA metabolism. RNA polyadenylation is catalyzed by poly(A) polymerases, which use ATP as a substrate to add adenine to the 3′ end of RNAs, which can ...
Charlotte Roux +9 more
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Borate Minerals and RNA Stability [PDF]
Polymers, 2010 The abiotic origin of genetic polymers faces two major problems: a prebiotically plausible polymerization mechanism and the maintenance of their polymerized state outside a cellular environment. The stabilizing action of borate on ribose having been reported, we have explored the possibility that borate minerals stabilize RNA.
Cristina Cossetti +2 more
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N6-methyladenosine RNA modification promotes viral genomic RNA stability and infection [PDF]
Nature Communications, 2022 Wheat production is threatened by wheat yellow mosaic virus (WYMV). Here, via genome-wide association study, the authors report that a putative methyltransferase B positively regulates WYMV infection through enhancing viral genomic RNA stability by N6 ...
Tianye Zhang +16 more
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Methylglyoxal-induced RNA modifications decrease RNA stability and translation and are associated with type 2 diabetes [PDF]
Molecular MetabolismObjectives: Methylglyoxal (MG), a reactive aldehyde generated as a byproduct of glucose and lipid metabolism, is known to modify nucleic acids and proteins, altering their structure and function.
Edwin De Jesus Lopez Gonzalez +10 more
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Unveiling RNA structure-mediated regulations of RNA stability in wheat [PDF]
Nature CommunicationsDespite the critical role of mRNA stability in post-transcriptional gene regulation, research on this topic in wheat, a vital agricultural crop, remains unclear. Our study investigated the mRNA decay landscape of durum wheat (Triticum turgidum L.
Haidan Wu +10 more
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Predicting 3D structure and stability of RNA pseudoknots in monovalent and divalent ion solutions. [PDF]
PLoS Computational Biology, 2018 RNA pseudoknots are a kind of minimal RNA tertiary structural motifs, and their three-dimensional (3D) structures and stability play essential roles in a variety of biological functions.
Ya-Zhou Shi +4 more
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The emerging role of RNA modifications in the regulation of mRNA stability
Experimental and Molecular Medicine, 2020 Gene activity: the significance of RNA modification Messenger RNA molecules play their key role in directing the manufacture of proteins via translating the genetic information in DNA.
Sung Ho Boo, Yoon Ki Kim
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RNA stability: a novel perspective on gene regulatory networks in bovine mastitis [PDF]
BMC GenomicsMastitis is a common and multifactorial disease in dairy cattle that leads to a major challenge in the livestock industry, in terms of both animal welfare and economic factors.
Mohammad Amin Shirazi +2 more
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Multiplexed assays of human disease-relevant mutations reveal UTR dinucleotide composition as a major determinant of RNA stability [PDF]
eLifeUntranslated regions (UTRs) contain crucial regulatory elements for RNA stability, translation and localization, so their integrity is indispensable for gene expression. Approximately 3.7% of genetic variants associated with diseases occur in UTRs, yet a
Jia-Ying Su +7 more
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