Results 51 to 60 of about 156,480 (199)
Nuclear Decay Factors Crack Up mRNA [PDF]
Molecular Cell, 2017 In this issue of Molecular Cell, Bresson et al. (2017) show that the nuclear RNA decay factors Nab3 and Mtr4 reshape the coding transcriptome during glucose starvation in budding yeast, placing nuclear mRNA metabolism as an important contributor of gene expression regulation.
Agnieszka Tudek +2 more
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Cell Reports, 2015 Apoptosis is a tightly coordinated cell death program that damages mitochondria, DNA, proteins, and membrane lipids. Little is known about the fate of RNA as cells die.
Marshall P. Thomas +7 more
doaj +1 more source
Ornithine Decarboxylase mRNA is Stabilized in an mTORC1-dependent Manner in Ras-transformed Cells [PDF]
, 2012 Upon Ras activation, ODC (ornithine decarboxylase) is markedly induced, and numerous studies suggest that ODC expression is controlled by Ras effector pathways. ODC is therefore a potential target in the treatment and prevention of Ras-driven tumours. In
Albig +51 more
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Initiation of mRNA decay in bacteria [PDF]
Cellular and Molecular Life Sciences, 2013 The instability of messenger RNA is fundamental to the control of gene expression. In bacteria, mRNA degradation generally follows an "all-or-none" pattern. This implies that if control is to be efficient, it must occur at the initiating (and presumably rate-limiting) step of the degradation process. Studies of E. coli and B.
S., Laalami, L., Zig, H., Putzer
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Virus-mediated mRNA decay by hyperadenylation [PDF]
Genome Biology, 2009 Degradation of cellular mRNAs during Kaposi's sarcoma-associated herpesvirus infection is associated with hyperadenylation of transcripts and a relocalization of cytoplasmic poly(A)-binding proteins to the nucleus.
Sokoloski, Kevin J +2 more
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Full UPF3B function is critical for neuronal differentiation of neural stem cells [PDF]
, 2015 Acknowledgments We thank Fred H Gage (Salk Institute, La Jolla, CA, USA) for HCN-A94 cells and Niels Gehring (University of Cologne, Germany) for constructs.
Alrahbeni, Tahani +5 more
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Systematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cells. [PDF]
PLoS ONE, 2010 Dramatic changes in gene expression occur in response to extracellular stimuli and during differentiation. Although transcriptional effects are important, alterations in mRNA decay also play a major role in achieving rapid and massive changes in mRNA ...
Jerome E Lee +4 more
doaj +1 more source
tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. [PDF]
, 2019 Yeast tRNA ligase (Trl1) is an essential trifunctional enzyme that catalyzes exon-exon ligation during tRNA biogenesis and the non-conventional splicing of HAC1 mRNA during the unfolded protein response (UPR).
Peschek, Jirka, Walter, Peter
core
Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. [PDF]
, 2013 One third of inherited genetic diseases are caused by mRNAs harboring premature termination codons as a result of nonsense mutations. These aberrant mRNAs are degraded by the Nonsense-Mediated mRNA Decay (NMD) pathway.
Bracho, Dina P +11 more
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mRNA Degradation and Decay [PDF]
, 2014 Why is it important to understand mRNA degradation in a cell? First,RNA degradation has a clearing function and removes RNAs arising from tran-scription, splicing, export, or translation “accidents” to ensure robust geneexpression (see Chap. 8). Second, while regulation of gene expression has a veryimportant transcription component, mRNAs must be ...
Fromont-Racine, Micheline +1 more
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