Results 61 to 70 of about 156,480 (199)
Monitoring mRNA Half-Life in Arabidopsis Using Droplet Digital PCR
Plants, 2022 mRNA decay is an important process in post-transcriptional regulation; in addition, it plays a crucial role in plant development and response to stress.
Alexandre Boubegtitene, Rémy Merret
doaj +1 more source
Micro-RNA mediated regulation of a cytokine factor: TNF-alpha: an exploration of gene expression control in proliferating and quiescent cells [PDF]
, 2016 Two types mechanisms that control gene expression involve cis-regulatory factors and trans-regulatory factors. Cis-acting regulatory RNAs include targeted messenger RNA (mRNA) specificity and AU-rich elements (AREs).
Bhambhani, Vijeta
core +1 more source
A novel class of microRNA-recognition elements that function only within open reading frames. [PDF]
, 2018 MicroRNAs (miRNAs) are well known to target 3' untranslated regions (3' UTRs) in mRNAs, thereby silencing gene expression at the post-transcriptional level.
A Aizer +85 more
core +2 more sources
Interactions between the HIV-1 Unspliced mRNA and Host mRNA Decay Machineries
Viruses, 2016 The human immunodeficiency virus type-1 (HIV-1) unspliced transcript is used both as mRNA for the synthesis of structural proteins and as the packaged genome. Given the presence of retained introns and instability AU-rich sequences, this viral transcript
Daniela Toro-Ascuy +3 more
doaj +1 more source
CELFish ways to modulate mRNA decay [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013 The CELF family of RNA-binding proteins regulates many steps of mRNA metabolism. Although their best characterized function is in pre-mRNA splice site choice, CELF family members are also powerful modulators of mRNA decay. In this review we focus on the different modes of regulation that CELF proteins employ to mediate mRNA decay by binding to GU-rich ...
Irina, Vlasova-St Louis +3 more
openaire +2 more sources
Retrovirology, 2019 Background Mammalian cells harbour RNA quality control and degradative machineries such as nonsense-mediated mRNA decay that target cellular mRNAs for clearance from the cell to avoid aberrant gene expression.
Shringar Rao +5 more
doaj +1 more source
Filtering for nonlinear genetic regulatory networks with stochastic disturbances [PDF]
, 2008 In this paper, the filtering problem is investigated for nonlinear genetic regulatory networks with stochastic disturbances and time delays, where the nonlinear function describing the feedback regulation is assumed to satisfy the sector condition, the ...
Fraser, K +4 more
core +1 more source
Extensive reshaping of bacterial operons by programmed mRNA decay. [PDF]
PLoS Genetics, 2018 Bacterial operons synchronize the expression of multiple genes by placing them under the control of a shared promoter. It was previously shown that polycistronic transcripts can undergo differential RNA decay, leaving some genes within the polycistron ...
Daniel Dar, Rotem Sorek
doaj +1 more source
Genome-wide profiling of uncapped mRNA [PDF]
, 2012 Gene transcripts are under extensive posttranscriptional regulation, including the regulation of their stability. A major route for mRNA degradation produces uncapped mRNAs, which can be generated by decapping enzymes, endonucleases, and small RNAs ...
BD Gregory +9 more
core +2 more sources
Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6. [PDF]
, 2014 BackgroundConventional p38α inhibitors have limited efficacy in rheumatoid arthritis, possibly because p38 blockade suppresses the counter-regulatory mechanisms that limit inflammation.
Boyle, David L +3 more
core +3 more sources