Results 81 to 90 of about 156,480 (199)
Molecular Systems Biology, 2016 Precise regulation of mRNA decay is fundamental for robust yet not exaggerated inflammatory responses to pathogens. However, a global model integrating regulation and functional consequences of inflammation‐associated mRNA decay remains to be established.
Vitaly Sedlyarov +10 more
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Conserved noncoding sequences are associated with rates of mRNA decay in Arabidopsis
Frontiers in Plant Science, 2013 Steady-state mRNA levels are tightly regulated through a combination of transcriptional and post-transcriptional control mechanisms. The discovery of cis-acting DNA elements that encode these control mechanisms is of high importance. We have investigated
Jacob B Spangler, Frank Alex Feltus
doaj +1 more source
eLife, 2018 Alterations in global mRNA decay broadly impact multiple stages of gene expression, although signals that connect these processes are incompletely defined.
Sarah Gilbertson +4 more
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Interaction of yeast eIF4G with spliceosome components Implications in pre-mRNA processing events [PDF]
, 2009 International audienceAs evidenced from mammalian cells the eukaryotic translation initiation factor eIF4G has a putative role in nuclear RNA metabolism. Here we investigate whether this role is conserved in the yeast Saccharomyces cerevisiae.
Barrass, J. David +6 more
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Translation Initiation Control of RNase E-Mediated Decay of Polycistronic gal mRNA
Frontiers in Molecular Biosciences, 2020 In bacteria, mRNA decay is a major mechanism for regulating gene expression. In Escherichia coli, mRNA decay initiates with endonucleolytic cleavage by RNase E. Translating ribosomes impede RNase E cleavage, thus providing stability to mRNA.
Heung Jin Jeon +6 more
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The exonuclease Xrn1 activates transcription and translation of mRNAs encoding membrane proteins
Nature Communications, 2019 The exonuclease Xrn1 mediates crosstalk between transcription and mRNA decay in yeast. Here the authors demonstrate that Xrn1 promotes translation of mRNAs encoding membrane proteins, coupling transcription, translation, and mRNA decay.
Bernat Blasco-Moreno +12 more
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GC content shapes mRNA storage and decay in human cells
eLife, 2019 mRNA translation and decay appear often intimately linked although the rules of this interplay are poorly understood. In this study, we combined our recent P-body transcriptome with transcriptomes obtained following silencing of broadly acting mRNA decay
Maïté Courel +17 more
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The translational repressors Nanos and Pumilio have divergent effects on presynaptic terminal growth and postsynaptic glutamate receptor subunit composition [PDF]
, 2009 Pumilio (Pum) is a translational repressor that binds selectively to target mRNAs and recruits Nanos (Nos) as a corepressor. In the larval neuromuscular system, Pum represses expression of the translation factor eIF-4E and the glutamate receptor subunit ...
Andrews, Shane +4 more
core +1 more source
Nonsense-mediated mRNA Decay and Cancer
Current Opinion in Genetics & Development, 2018 Nonsense-mediated mRNA decay (NMD) is a conserved mRNA surveillance pathway that cells use to ensure the quality of transcripts and to fine-tune transcript abundance. The role of NMD in cancer development is complex. In some cases, tumors have exploited NMD to downregulate gene expression by apparently selecting for mutations causing destruction of key
Maximilian W, Popp, Lynne E, Maquat
openaire +3 more sources
Insights into the assembly and architecture of a Staufen-mediated mRNA decay (SMD)-competent mRNP
Nature Communications, 2019 The Staufen proteins recognize secondary structures in 3’-untranslated regions in mRNA transcripts and induce degradation of these mRNAs with the help of the RNA helicase UPF1.
Manjeera Gowravaram +4 more
doaj +1 more source