Results 91 to 100 of about 156,480 (199)

Dual RNA Processing Roles of Pat1b via Cytoplasmic Lsm1-7 and Nuclear Lsm2-8 Complexes

Cell Reports, 2017
Summary: Pat1 RNA-binding proteins, enriched in processing bodies (P bodies), are key players in cytoplasmic 5′ to 3′ mRNA decay, activating decapping of mRNA in complex with the Lsm1-7 heptamer.
Caroline Vindry, Aline Marnef, Helen Broomhead, Laure Twyffels, Sevim Ozgur, Georg Stoecklin, Miriam Llorian, Christopher W. Smith, Juan Mata, Dominique Weil, Nancy Standart   +10 more
doaj   +1 more source

Dynamics of gene expression and the regulatory inference problem

, 2008
From the response to external stimuli to cell division and death, the dynamics of living cells is based on the expression of specific genes at specific times.
, Alon U., Chen W. England J. Shakhnovich E., Hertz J., Honerkamp J., J. Berg, Lèbre S., Michaelis L., Spellman P. T., Stokic D. Hanel R. Thurner S., van Kampen N.   +10 more
core   +1 more source

mRNA decay in mammals

The FASEB Journal, 2012
In mammals, two different messenger ribonucleoproteins (mRNPs) serve as templates for protein synthesis. Newly synthesized CBP80‐CBP20 (CBC)‐bound mRNPs initially undergo a pioneer round of translation (Maquat et al., 2010). One purpose of this round is to ensure the quality of gene expression, as exemplified by nonsense‐mediated mRNA decay (NMD).
openaire   +1 more source

Cytoplasmic 5’-3’ exonuclease Xrn1p is also a genome-wide transcription factor in yeast

Frontiers in Genetics, 2014
The 5’ to 3’ exoribonuclease Xrn1 is a large protein involved in cytoplasmatic mRNA degradation as a critical component of the major decaysome. Its deletion in the yeast Saccharomyces cerevisiae is not lethal, but it has multiple physiological effects ...
Daniel A Medina, Antonio eJordán-Pla, Gonzalo eMillán-Zambrano, Sebastián eChávez, Mordechai eChoder, José E Pérez-Ortín   +5 more
doaj   +1 more source

Simulation based sequential Monte Carlo methods for discretely observed Markov processes [PDF]

, 2014
Parameter estimation for discretely observed Markov processes is a challenging problem. However, simulation of Markov processes is straightforward using the Gillespie algorithm.
Neal, Peter
core  

mRNA Decay [PDF]

Molecular Cell, 2003
Long, Roy M, McNally, Mark T
openaire   +1 more source

Attenuating ribosome load improves protein output from mRNA by limiting translation-dependent mRNA decay

Cell Reports
Summary: Developing an effective mRNA therapeutic often requires maximizing protein output per delivered mRNA molecule. We previously found that coding sequence (CDS) design can substantially affect protein output, with mRNA variants containing more ...
Alicia A. Bicknell, David W. Reid, Marissa C. Licata, Adriana K. Jones, Yi Min Cheng, Mengying Li, Chiaowen Joyce Hsiao, Christopher S. Pepin, Mihir Metkar, Yevgen Levdansky, Brian R. Fritz, Elizaveta A. Andrianova, Ruchi Jain, Eugene Valkov, Caroline Köhrer, Melissa J. Moore   +15 more
doaj   +1 more source

UPF1 regulates mRNA stability by sensing poorly translated coding sequences

Cell Reports
Summary: Post-transcriptional mRNA regulation shapes gene expression, yet how cis-elements and mRNA translation interface to regulate mRNA stability is poorly understood.
Damir Musaev, Mario Abdelmessih, Charles E. Vejnar, Valeria Yartseva, Linnea A. Weiss, Ethan C. Strayer, Carter M. Takacs, Antonio J. Giraldez   +7 more
doaj   +1 more source

SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA.

PLoS ONE, 2013
mRNAs targeted by endonuclease decay generally disappear without detectable decay intermediates. The exception to this is nonsense-containing human β-globin mRNA, where the destabilization of full-length mRNA is accompanied by the cytoplasmic ...
Roshan Mascarenhas, Julie A Dougherty, Daniel R Schoenberg   +2 more
doaj   +1 more source

Origins of Binary Gene Expression in Post-transcriptional Regulation by MicroRNAs

, 2012
MicroRNA-mediated regulation of gene expression is characterised by some distinctive features that set it apart from unregulated and transcription factor-regulated gene expression. Recently, a mathematical model has been proposed to describe the dynamics
Bose, Indrani, Ghosh, Sayantari
core   +1 more source