Results 101 to 110 of about 156,480 (199)

UPF1/SMG7-dependent microRNA-mediated gene regulation

Nature Communications, 2019
UPF1 mediates the decay of target mRNA in a 3′ untranslated region (UTR)-length-dependent manner. Here the authors reveal that the 3′UTR-length-dependent regulation of UPF1-dependent mRNA decay occurs through EJC-independent but miRNA-dependent ...
Jungyun Park, Jwa-Won Seo, Narae Ahn, Seokju Park, Jungwook Hwang, Jin-Wu Nam   +5 more
doaj   +1 more source

Attenuation of transcriptional bursting in mRNA transport

, 2009
Due to the stochastic nature of biochemical processes, the copy number of any given type of molecule inside a living cell often exhibits large temporal fluctuations.
Izaurralde E, Lei-han Tang, Li-ping Xiong, Van Kampen N G, Yu-qiang Ma   +4 more
core   +1 more source

mRNA turnover rate limits siRNA and microRNA efficacy

Molecular Systems Biology, 2010
The microRNA pathway participates in basic cellular processes and its discovery has enabled the development of si/shRNAs as powerful investigational tools and potential therapeutics. Based on a simple kinetic model of the mRNA life cycle, we hypothesized
Erik Larsson, Chris Sander, Debora Marks
doaj   +1 more source

Early LQT2 Nonsense Mutation Generates N-Terminally Truncated hERG Channels with Altered Gating Properties by the Reinitiation of Translation

, 2012
Mutations in the human ether-a-go-go-related gene (hERG) result in long QT syndrome type 2 (LQT2). The hERG gene encodes a K+ channel that contributes to the repolarization of the cardiac action potential.
Gong, Qiuming, Packer, Jonathan D., Stump, Matthew R., Zhou, Zhengfeng   +3 more
core   +1 more source

A rapid inducible RNA decay system reveals fast mRNA decay in P-bodies

Nature Communications
RNA decay is vital for regulating mRNA abundance and gene expression. Existing technologies lack the spatiotemporal precision or transcript specificity to capture the stochastic and transient decay process.
Lauren A. Blake, Leslie Watkins, Yang Liu, Takanari Inoue, Bin Wu   +4 more
doaj   +1 more source

PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation

Cell & Bioscience
Background Oocyte maturation defect (OMD) and early embryonic arrest result in female infertility. Previous studies have linked biallelic mutations in the PATL2 gene to OMD, yet the underlying mechanism remains largely unknown.
Yin-Li Zhang, Zhanhong Hu, Huifang Jiang, Jiamin Jin, Yan Zhou, Mengru Lai, Peipei Ren, Siya Liu, Ying-Yi Zhang, Yan Rong, Wei Zheng, Shen Zhang, Xiaomei Tong, Songying Zhang   +13 more
doaj   +1 more source

Nonsense-mediated mRNA decay [PDF]

Current Biology, 2002
openaire   +2 more sources

SnapShot: Nonsense-Mediated mRNA Decay

Cell, 2011
Durand, Sébastien, Lykke-Andersen, Jens
openaire   +2 more sources

A knock-in tristetraprolin (TTP) zinc finger point mutation in mice: Comparison with complete TTP deficiency [PDF]

, 2018
Blackshear, Perry J, Faccio, Roberta, Lai, Wi S, Qiu, Lianqun, Stumpo, Deborah J   +4 more
core   +2 more sources

Nonsense-mediated mRNA decay safeguards telomeres in pluripotent stem cells. [PDF]

Nat Cell Biol
Markiewicz-Potoczny M, Lee SY, Chatterjee S, Mabin JW, Zinsser A, Sandhu R, Tricola G, Hogg JR, Lazzerini Denchi E.   +8 more
europepmc   +1 more source