Modeling of mRNA deadenylation rates reveal a complex relationship between mRNA deadenylation and decay [PDF]
EMBO JournalComplete cytoplasmic polyadenosine tail (polyA-tail) deadenylation is thought to be essential for initiating mRNA decapping and subsequent degradation. To investigate this prevalent model, we conducted direct RNA sequencing of S. cerevisiae mRNAs derived
Jarosław Daw Poznański +2 more
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Pan2‐Pan3 Complex‐Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus [PDF]
Advanced SciencePoly(A) tail shortening by deadenylases is a central checkpoint linking mRNA fate to eukaryotic development, yet its impact on fungal pathogenesis remains unexplored.
Ziwei Lv +6 more
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RNA degradation triggered by decapping is largely independent of initial deadenylation [PDF]
EMBO JournalRNA stability, important for eukaryotic gene expression, is thought to depend on deadenylation rates, with shortened poly(A) tails triggering decapping and 5′ to 3′ degradation.
abdelkader Namane +2 more
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CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State
Stem Cell Reports, 2016 Poly(A) tail length and mRNA deadenylation play important roles in gene regulation. However, how they regulate embryonic development and pluripotent cell fate is not fully understood.
Xiaofeng Zheng, Pengyi Yang, Lackford B
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Multivalent interactions with CCR4–NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin [PDF]
Nature CommunicationsTristetraprolin family of proteins regulate mRNA stability by binding to specific AU-rich elements in transcripts. This binding promotes the shortening of the mRNA poly(A) tail, or deadenylation, initiating mRNA degradation.
Filip Pekovic +6 more
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Preserving the Poly(A) Tail: Strategies Viruses Use to ‘CYA’ (Cover Your A’s) [PDF]
VirusesThe poly(A) tail on viral mRNAs plays an important role in gene expression, given the role of the 3′ mRNA tail in mRNA stability and translation. Viruses have developed several strategies to maintain the integrity of their poly(A) tails.
Jeffrey Wilusz
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A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C [PDF]
Nature Communications, 2015 The regulation of protein and mRNA turnover is essential for many cellular processes. We recently showed that ubiquitin--traditionally linked to protein degradation--directly regulates the degradation of mRNAs through the action of a newly identified ...
Radu Rapiteanu
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Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytes [PDF]
Nature CommunicationsOocyte in vitro maturation is a technique in assisted reproductive technology. Thousands of genes show abnormally high expression in in vitro maturated metaphase II (MII) oocytes compared to those matured in vivo in bovines, mice, and humans.
Yusheng Liu +11 more
doaj +2 more sources
Recycling of Uridylated mRNAs in Starfish Embryos [PDF]
BiomoleculesIn eukaryotes, mRNAs with long poly(A) tails are translationally active, but deadenylation and uridylation of these tails generally cause mRNA degradation. However, the fate of uridylated mRNAs that are not degraded quickly remains obscure.
Haruka Yamazaki +5 more
doaj +2 more sources
Estrogen receptor alpha (ERα) regulates PARN-mediated nuclear deadenylation and gene expression in breast cancer cells [PDF]
RNA BiologyThe estrogen signalling pathway is highly dynamic and primarily mediated by estrogen receptors (ERs) that transcriptionally regulate the expression of target genes.
Sophia Varriano +5 more
doaj +2 more sources