Modeling of mRNA deadenylation rates reveal a complex relationship between mRNA deadenylation and decay [PDF]
EMBO JournalComplete cytoplasmic polyadenosine tail (polyA-tail) deadenylation is thought to be essential for initiating mRNA decapping and subsequent degradation. To investigate this prevalent model, we conducted direct RNA sequencing of S. cerevisiae mRNAs derived
Torben Heick Jensen +2 more
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RNA degradation triggered by decapping is largely independent of initial deadenylation [PDF]
EMBO JournalRNA stability, important for eukaryotic gene expression, is thought to depend on deadenylation rates, with shortened poly(A) tails triggering decapping and 5′ to 3′ degradation.
Abdelkader Namane +2 more
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Pan2‐Pan3 Complex‐Mediated Deadenylation Enforces mRNA Quality Control for Infection of the Rice Blast Fungus [PDF]
Advanced SciencePoly(A) tail shortening by deadenylases is a central checkpoint linking mRNA fate to eukaryotic development, yet its impact on fungal pathogenesis remains unexplored.
Ziwei Lv +6 more
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Multivalent interactions with CCR4–NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin [PDF]
Nature CommunicationsTristetraprolin family of proteins regulate mRNA stability by binding to specific AU-rich elements in transcripts. This binding promotes the shortening of the mRNA poly(A) tail, or deadenylation, initiating mRNA degradation.
Filip Pekovic +6 more
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Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex
Frontiers in Cell and Developmental Biology, 2023 Accurate and precise regulation of gene expression programmes in eukaryotes involves the coordinated control of transcription, mRNA stability and translation.
Lorenzo Pavanello +2 more
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Torpor-Induced Regulation of Poly(A) Tail Machinery in 13-Lined Ground Squirrel Brown Adipose Tissue [PDF]
Journal of Developmental BiologyThe poly(A) tail has long been known to play a central role in mRNA stability, storage, and translational competence, making it a potential key regulator during hypometabolic states. During seasonal torpor, hibernating mammals must frequently enter these
Saif Rehman +2 more
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Preserving the Poly(A) Tail: Strategies Viruses Use to ‘CYA’ (Cover Your A’s) [PDF]
VirusesThe poly(A) tail on viral mRNAs plays an important role in gene expression, given the role of the 3′ mRNA tail in mRNA stability and translation. Viruses have developed several strategies to maintain the integrity of their poly(A) tails.
Jeffrey Wilusz
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CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State
Stem Cell Reports, 2016 Poly(A) tail length and mRNA deadenylation play important roles in gene regulation. However, how they regulate embryonic development and pluripotent cell fate is not fully understood.
Carmen Williams +2 more
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Cell ReportsSummary: Without new transcription, gene expression across the oocyte-to-embryo transition (OET) relies instead on regulation of mRNA poly(A) tails to control translation.
Katherine Lee +3 more
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Rapid nuclear deadenylation of mammalian messenger RNA
iScience, 2023 Summary: Poly(A) tails protect RNAs from degradation and their deadenylation rates determine RNA stability. Although poly(A) tails are generated in the nucleus, deadenylation of tails has mostly been investigated within the cytoplasm.
Jonathan Alles +3 more
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