Results 1 to 10 of about 16,151,399 (172)
Immunology, EarlyView.During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu +24 more
wiley +1 more source
FEBS Open Bio, 2019 In eukaryotic cells, cytoplasmic mRNA is characterised by a 3′ poly(A) tail. The shortening and removal of poly(A) tails (deadenylation) by the Ccr4‐Not nuclease complex leads to reduced translational efficiency and RNA degradation.
Blessing Airhihen +4 more
doaj +1 more source
Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis
Journal of the European Academy of Dermatology and Venereology, EarlyView.Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs +6 more
wiley +1 more source
Circular RNAs in Lotus japonicus Responses to Nutrient Supply and Mesorhizobium Symbiosis
Plant, Cell &Environment, EarlyView.ABSTRACT Symbiotic interactions between legumes and rhizobia enable nitrogen fixation under low nutrient conditions. The establishment and function of symbiotic interactions require coordinated changes in gene expression in both the host and the microbe. Circular RNAs (circRNAs) are endogenous gene‐specific molecules that can regulate transcription and
Delecia Utley +3 more
wiley +1 more source
RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases
Frontiers in Cardiovascular Medicine, 2019 The increasing prevalence of worldwide obesity has emerged as a major risk factor for type 2 diabetes (T2D), hepatosteatosis, and cardiovascular disease. Accumulating evidence indicates that obesity has strong inflammatory underpinnings tightly linked to
Esam S. B. Salem +8 more
doaj +1 more source
Etiology, pathogenesis and treatment of peri‐implantitis: A European perspective
Periodontology 2000, EarlyView.Abstract Peri‐implantitis is a plaque‐associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri‐implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri‐implantitis has become a major disease burden in dentistry.
Tord Berglundh +3 more
wiley +1 more source
The architecture of the Schizosaccharomyces pombe CCR4-NOT complex
Nature Communications, 2016 CCR4-NOT is a protein complex involved in a variety of important genetic processes. Here, the authors report the mid-resolution structure of this complex, and model the positions and contacts between the subunits, providing structural support for the ...
Marta Ukleja +7 more
doaj +1 more source
Quantitative Biology, Volume 14, Issue 3, September 2026.Abstract Single‐cell multi‐omics sequencing technology provides a powerful tool for studying cellular heterogeneity. However, beyond the challenges of sparsity, heterogeneity, and dimensionality differences, a critical challenge in multi‐omics data integration lies in preserving the true regulatory relationships among molecular features.
Yucheng Lu, Xun Zhang, Hongwei Li
wiley +1 more source
European Journal of Haematology, Volume 117, Issue 2, Page 481-491, August 2026.ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy with a poor prognosis and limited therapeutic options. ATL cells exhibit aberrant surface glycosylation patterns resulting from dysregulated glycosyltransferase expression, representing a potentially tumor‐specific therapeutic target.
Yuichiro Uchida +7 more
wiley +1 more source