Results 1 to 10 of about 2,257 (136)
The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation [PDF]
Life Science Alliance, 2020 The CCR4–NOT complex maintains liver homeostasis by fine-tuning levels of mRNAs, including those for transcription factors, cell cycle regulators, DNA damage response proteins, and liver function–related molecules.
Akinori Takahashi +12 more
doaj +3 more sources
Novel roles of the multifunctional CCR4-NOT complex in post-transcriptional regulation [PDF]
Frontiers in Genetics, 2014 The CCR4-NOT complex is highly conserved gene silencer, and more general functions of the complex have been elucidated at post-transcriptional levels. Specific regulatory proteins, including miRNA-induced silencing complex and its associate protein, bind
Toshifumi eInada, Shiho eMakino
doaj +2 more sources
Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex [PDF]
Frontiers in Genetics, 2013 The shortening of the poly(A) tail of cytoplasmic mRNA (deadenylation) is a pivotal step in the regulation of gene expression in eukaryotic cells. Deadenylation impacts on both regulated mRNA decay as well as the rate of mRNA translation.
Gerlof Sebastiaan Winkler +1 more
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CCR4 1014C/T and CCL22 16C/A Genetic Variations in Iranian Patients with Thyroid Cancer [PDF]
Middle East Journal of Cancer, 2022 Background: The aim of this study was to investigate the association between thyroid cancer and 16C/A single nucleotide polymorphism (SNP) in C-C motif chemokine 22 (CCL22) as well as 1014C/T SNP in C-C chemokine receptor type 4 (CCR4).Method: In this ...
Mohammad Hossein Dabbaghmanesh +5 more
doaj +1 more source
G3: Genes, Genomes, Genetics, 2018 The Ccr4 (carbon catabolite repression 4)-Not complex is a major regulator of stress responses that controls gene expression at multiple levels, from transcription to mRNA decay.
Jason E. Miller +5 more
doaj +1 more source
Translational control of ERK signaling through miRNA/4EHP-directed silencing
eLife, 2018 MicroRNAs (miRNAs) exert a broad influence over gene expression by directing effector activities that impinge on translation and stability of mRNAs.
Seyed Mehdi Jafarnejad +18 more
doaj +1 more source
Interaction between NANOS2 and the CCR4-NOT deadenylation complex is essential for male germ cell development in mouse. [PDF]
PLoS ONE, 2012 Nanos is one of the evolutionarily conserved proteins implicated in germ cell development and we have previously shown that it interacts with the CCR4-NOT deadenylation complex leading to the suppression of specific RNAs. However, the molecular mechanism
Atsushi Suzuki +4 more
doaj +1 more source
eLife, 2020 Stem cells support tissue maintenance, but the mechanisms that coordinate the rate of stem cell self-renewal with differentiation at a population level remain uncharacterized. We find that two PUF family RNA-binding proteins FBF-1 and FBF-2 have opposite
Xiaobo Wang +6 more
doaj +1 more source
Advanced Science, EarlyView.Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong +10 more
wiley +1 more source
Role of Cnot6l in maternal mRNA turnover
Life Science Alliance, 2018 Mice lacking Cnot6l , a deadenylase component of the CCR4–NOT complex, are viable, but females have ∼40% smaller litters. Cnot6l is a maternal-effect gene acting in maternal mRNA degradation.
Filip Horvat +9 more
doaj +1 more source