Results 31 to 40 of about 16,151,399 (172)

The Not4 E3 ligase and CCR4 deadenylase play distinct roles in protein quality control. [PDF]

PLoS ONE, 2014
Eukaryotic cells control their proteome by regulating protein production and protein clearance. Protein production is determined to a large extent by mRNA levels, whereas protein degradation depends mostly upon the proteasome.
David Halter, Martine A Collart, Olesya O Panasenko   +2 more
doaj   +1 more source

CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance

eLife, 2023
Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T cell lineage, thus preventing autoimmunity. To undergo central tolerance, thymocytes must enter the medulla to test their T-cell receptors (TCRs) for ...
Yu Li, Pablo Guaman Tipan, Hilary J Selden, Jayashree Srinivasan, Laura P Hale, Lauren IR Ehrlich   +5 more
doaj   +1 more source

The cellular roles of Ccr4-NOT in model and pathogenic fungi – implications for fungal virulence

Frontiers in Genetics, 2013
The fungal Ccr4-NOT complex has been implicated in orchestrating gene expression networks that impact on pathways key for virulence in pathogenic species.
John C. Panepinto, Eva eHeinz, Ana eTraven   +2 more
doaj   +1 more source

infection

, 2023
Unlike most RNA and DNA viruses that broadly stimulate mRNA decay and interfere with host gene expression, human cytomegalovirus (HCMV) extensively remodels the host translatome without producing an mRNA decay enzyme.
Riccio, Sofia, Ikshitaa Dinesh, Grande, Rebecca, Rebecca Grande, Sofia Riccio, Gerlof Sebastiaan Winkler, Daniel P Depledge, Burgess, Hannah M, Dinesh, Ikshitaa, Depledge, Daniel P, Mohr, Ian, Winkler, Gerlof Sebastiaan, Hannah M Burgess, Ian Mohr   +13 more
core   +1 more source

Insights into the structure and architecture of the CCR4-NOT complex

Frontiers in Genetics, 2014
The CCR4-NOT complex is a highly conserved, multifunctional machinery with a general role in controlling mRNA metabolism. It has been implicated in a number of different aspects of mRNA and protein expression, including mRNA degradation, transcription ...
Kun eXu, Yuwei eBai, Aili eZhang, Qionglin eZhang, Mark Gerrard Bartlam   +4 more
doaj   +1 more source

Genome-Wide Mapping of Decay Factor–mRNA Interactions in Yeast Identifies Nutrient-Responsive Transcripts as Targets of the Deadenylase Ccr4

G3: Genes, Genomes, Genetics, 2018
The Ccr4 (carbon catabolite repression 4)-Not complex is a major regulator of stress responses that controls gene expression at multiple levels, from transcription to mRNA decay.
Jason E. Miller, Liye Zhang, Haoyang Jiang, Yunfei Li, B. Franklin Pugh, Joseph C. Reese   +5 more
doaj   +1 more source

Translational control of ERK signaling through miRNA/4EHP-directed silencing

eLife, 2018
MicroRNAs (miRNAs) exert a broad influence over gene expression by directing effector activities that impinge on translation and stability of mRNAs.
Seyed Mehdi Jafarnejad, Clément Chapat, Edna Matta-Camacho, Idit Anna Gelbart, Geoffrey G Hesketh, Meztli Arguello, Aitor Garzia, Sung-Hoon Kim, Jan Attig, Maayan Shapiro, Masahiro Morita, Arkady Khoutorsky, Tommy Alain, Christos, G Gkogkas, Noam Stern-Ginossar, Thomas Tuschl, Anne-Claude Gingras, Thomas F Duchaine, Nahum Sonenberg   +18 more
doaj   +1 more source

Ccr4-Not complex components genetically interact with and and play a role in transcription elongation

, 2011
Copyright information:Taken from "Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex"Nucleic Acids Research 2007;35(7):2428-2439.Published online 28 Mar 2007PMCID:PMC1874646.© 2007 The Author(s) () Tetrad ...
Akiko Inagaki (30053), H. Th. Marc Timmers (10936), Niels J. F. van den Broek (30054), Klaas W. Mulder (12134), Arjan B. Brenkman (30052)   +4 more
core   +1 more source

The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylation

Life Science Alliance, 2020
The CCR4–NOT complex maintains liver homeostasis by fine-tuning levels of mRNAs, including those for transcription factors, cell cycle regulators, DNA damage response proteins, and liver function–related molecules.
Akinori Takahashi, Toru Suzuki, Shou Soeda, Shohei Takaoka, Shungo Kobori, Tomokazu Yamaguchi, Haytham Mohamed Aly Mohamed, Akiko Yanagiya, Takaya Abe, Mayo Shigeta, Yasuhide Furuta, Keiji Kuba, Tadashi Yamamoto   +12 more
doaj   +1 more source

The Ccr4–Not complex

, 2012
The Ccr4-Not complex is a unique, essential and conserved multi-subunit complex that acts at the level of many different cellular functions to regulate gene expression.
Olesya O. Panasenko, Martine A. Collart, Collart, Martine, Panasenko, Olesya   +3 more
core   +1 more source