Results 31 to 40 of about 2,257 (136)

Twin Promotes the Maintenance and Differentiation of Germline Stem Cell Lineage through Modulation of Multiple Pathways

Cell Reports, 2015
The central question in stem cell regulation is how the balance between self-renewal and differentiation is controlled at the molecular level. This study uses germline stem cells (GSCs) in the Drosophila ovary to demonstrate that the Drosophila CCR4 ...
Ziwen Fu, Cuiyun Geng, Hui Wang, Zhihao Yang, Changjiang Weng, Hua Li, Lamei Deng, Luping Liu, Nan Liu, Jianquan Ni, Ting Xie   +10 more
doaj   +1 more source

Trametinib improves Treg selectivity of anti-CCR4 antibody by regulating CCR4 expression in CTLs in oral squamous cell carcinoma

Scientific Reports, 2022
Regulatory T-cells (Tregs) play a major role in suppressing anti-tumor immune responses. Mogamulizumab, an anti-CC chemokine receptor type 4 (CCR4) monoclonal antibody, depletes effector Tregs (eTregs). However, the clinical efficacy of mogamulizumab was
Shoya Ono, Susumu Suzuki, Yutaro Kondo, Ikuko Okubo, Mitsuo Goto, Tetsuya Ogawa, Hidefumi Kato, Hideaki Ito, Taishi Takahara, Akira Satou, Toyonori Tsuzuki, Kazuhiro Yoshikawa, Toru Nagao, Ryuzo Ueda   +13 more
doaj   +1 more source

The Not4 E3 ligase and CCR4 deadenylase play distinct roles in protein quality control. [PDF]

PLoS ONE, 2014
Eukaryotic cells control their proteome by regulating protein production and protein clearance. Protein production is determined to a large extent by mRNA levels, whereas protein degradation depends mostly upon the proteasome.
David Halter, Martine A Collart, Olesya O Panasenko   +2 more
doaj   +1 more source

CCR4 and CCR7 differentially regulate thymocyte localization with distinct outcomes for central tolerance

eLife, 2023
Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T cell lineage, thus preventing autoimmunity. To undergo central tolerance, thymocytes must enter the medulla to test their T-cell receptors (TCRs) for ...
Yu Li, Pablo Guaman Tipan, Hilary J Selden, Jayashree Srinivasan, Laura P Hale, Lauren IR Ehrlich   +5 more
doaj   +1 more source

Insights into the structure and architecture of the CCR4-NOT complex

Frontiers in Genetics, 2014
The CCR4-NOT complex is a highly conserved, multifunctional machinery with a general role in controlling mRNA metabolism. It has been implicated in a number of different aspects of mRNA and protein expression, including mRNA degradation, transcription ...
Kun eXu, Yuwei eBai, Aili eZhang, Qionglin eZhang, Mark Gerrard Bartlam   +4 more
doaj   +1 more source

RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation [PDF]

, 2021
The CCR4-NOT complex acts as a central player in the control of mRNA turnover and mediates accelerated mRNA degradation upon HDAC inhibition. Here, we explored acetylation-induced changes in the composition of the CCR4-NOT complex by purification of the ...
Poetz, F., Levdansky, Y., Lebedeva, S., Spiegelhalter, A., Schott, J., Lindner, D., Corbo, J., Magg, V., Schweiggert, J., Valkov, E., Stoecklin, G.   +10 more
core   +1 more source

The Ccr4–Not complex

, 2012
The Ccr4-Not complex is a unique, essential and conserved multi-subunit complex that acts at the level of many different cellular functions to regulate gene expression.
Olesya O. Panasenko, Martine A. Collart, Collart, Martine, Panasenko, Olesya   +3 more
core   +1 more source

Architecture of the Nuclease Module of the Yeast Ccr4-Not Complex: the Not1-Caf1-Ccr4 Interaction

, 2012
Shortening eukaryotic poly(A) tails represses mRNA translation and induces mRNA turnover. The major cytoplasmic deadenylase, the Ccr4-Not complex, is a conserved multisubunit assembly.
Basquin, J., Conti, E., Rode, M, Séraphin, Bertrand, Roudko, Vladimir, Basquin, C, Conti, Eric, Basquin, C., Basquin, J, Roudko, V., Seraphin, B., Rode, M.   +11 more
core   +1 more source

Building on the Ccr4‐Not architecture

, 2016
In a recent issue of Nature Communications Ukleja and co-workers reported a cryo-EM 3D reconstruction of the Ccr4-Not complex from Schizosaccharomyces pombe with an immunolocalization of the different subunits.
Zoltan Villanyi, Martine A. Collart, Collart, Martine, Villanyi, Zoltan   +3 more
core   +1 more source

The multifunctional Ccr4–Not complex directly promotes transcription elongation

, 2011
The Ccr4–Not complex has been implicated in the control of multiple steps of mRNA metabolism; however, its functions in transcription remain ambiguous.
Arnob Dutta, David S. Gilmour, Jennifer A. Kruk, Jianhua Fu, Joseph C. Reese   +4 more
core   +1 more source