Results 11 to 20 of about 2,257 (136)
The Regulatory Properties of the Ccr4–Not Complex
Cells, 2020 The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression.
Nafiseh Chalabi Hagkarim, Roger J. Grand
exaly +4 more sources
The Ccr4-Not complex interacts with the mRNA export machinery. [PDF]
PLoS ONE, 2011 The Ccr4-Not complex is a key eukaryotic regulator of gene transcription and cytoplasmic mRNA degradation. Whether this complex also affects aspects of post-transcriptional gene regulation, such as mRNA export, remains largely unexplored.
Shana C Kerr +6 more
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RNF219 regulates CCR4-NOT function in mRNA translation and deadenylation
Scientific Reports, 2022 Post-transcriptional regulatory mechanisms play a role in many biological contexts through the control of mRNA degradation, translation and localization.
Aude Guénolé +7 more
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The CCR4-NOT complex physically and functionally interacts with TRAMP and the nuclear exosome. [PDF]
PLoS ONE, 2009 BACKGROUND:Ccr4-Not is a highly conserved multi-protein complex consisting in yeast of 9 subunits, including Not5 and the major yeast deadenylase Ccr4.
Nowel Azzouz +3 more
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Multifunctional roles of the mammalian CCR4-NOT complex in physiological phenomena
Frontiers in Genetics, 2014 The CCR4-NOT complex serves as one of the major deadenylases of eukaryotes. Although it was originally identified and characterized in yeast, recent studies have revealed that the CCR4-NOT complex also exerts important functions in mammals, including ...
Yo-Taro eShirai +5 more
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PLoS Genetics, 2020 The Ccr4-Not complex functions as an effector of multiple signaling pathways that control gene transcription and mRNA turnover. Consequently, Ccr4-Not contributes to a diverse array of processes, which includes a significant role in cell metabolism.
Hongfeng Chen +3 more
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The cellular roles of Ccr4-NOT in model and pathogenic fungi – implications for fungal virulence [PDF]
Frontiers in Genetics, 2013 The fungal Ccr4-NOT complex has been implicated in orchestrating gene expression networks that impact on pathways key for virulence in pathogenic species.
John C. Panepinto +2 more
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The architecture of the Schizosaccharomyces pombe CCR4-NOT complex
Nature Communications, 2016 CCR4-NOT is a protein complex involved in a variety of important genetic processes. Here, the authors report the mid-resolution structure of this complex, and model the positions and contacts between the subunits, providing structural support for the ...
Marta Ukleja +7 more
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Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation
Nature Communications, 2019 The CCR4-NOT complex shortens poly(A) tails of messenger RNAs. By biochemical reconstitution of the entire human CCR4-NOT complex, the authors show the stimulatory roles of non-enzymatic subunits and the importance of the interaction between CAF40 and ...
Tobias Raisch +5 more
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eLife, 2021 Phytochromes are photoreceptors regulating growth and development in plants. Using the model plant Arabidopsis, we identified a novel signalling pathway downstream of the far-red light-sensing phytochrome, phyA, that depends on the highly conserved CCR4 ...
Philipp Schwenk +10 more
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