Results 21 to 30 of about 2,257 (136)
, 2023 Unlike most RNA and DNA viruses that broadly stimulate mRNA decay and interfere with host gene expression, human cytomegalovirus (HCMV) extensively remodels the host translatome without producing an mRNA decay enzyme.
Riccio, Sofia +13 more
core +1 more source
Ccr4-not regulates RNA polymerase I transcription and couples nutrient signaling to the control of ribosomal RNA biogenesis. [PDF]
PLoS Genetics, 2015 Ribosomal RNA synthesis is controlled by nutrient signaling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway. mTORC1 regulates ribosomal RNA expression by affecting RNA Polymerase I (Pol I)-dependent transcription of the ribosomal ...
R Nicholas Laribee +3 more
doaj +1 more source
Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex
Frontiers in Cell and Developmental Biology, 2023 Accurate and precise regulation of gene expression programmes in eukaryotes involves the coordinated control of transcription, mRNA stability and translation.
Lorenzo Pavanello +2 more
doaj +1 more source
Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex
Frontiers in Immunology, 2021 Development of lymphocytes is precisely regulated by various mechanisms. In addition to transcriptional rates, post-transcriptional regulation of mRNA abundance contributes to differentiation of lymphocytes. mRNA decay is a post-transcriptional mechanism
Taishin Akiyama +2 more
doaj +1 more source
Biology Open, 2014 NANOS2 and NANOS3 belong to the Nanos family of proteins that contain a conserved zinc finger domain, which consists of two consecutive CCHC-type zinc finger motifs, and contribute to germ cell development in mice.
Atsushi Suzuki, Yuki Niimi, Yumiko Saga
doaj +1 more source
Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice
Journal of Pharmacological Sciences, 2023 Increasing evidence indicates that immune abnormalities are associated with the pathogenesis of depression. CCR4 is a chemokine receptor that regulates regulatory T cell (Treg) and Th17 cell migration.
Yuta Hara +5 more
doaj +1 more source
The role of TNRC6 proteins in gene silencing [PDF]
, 2013 Proteins of the GW182 family have recently emerged as key players in miRNAmediated gene silencing. They have been shown to interact with Argonaute proteins, components of the RISC and are assumed to mediate the repression in metazoa. Three paralogues are
Zipprich, Jakob Theophil
core +1 more source
Functional Analysis of CCR4-NOT Complex in Pancreatic β Cell [PDF]
, 2020 Okinawa Institute of Science and Technology Graduate UniversityDoctor of PhilosophyFunctional analysis of CCR4-NOT complex in pancreatic β cell Pancreatic β cells are responsible for production and secretion of insulin in response to increasing blood ...
Mostafa, Dina
core +1 more source
mSphere, 2016 Ccr4, a component of the Ccr4-Not cytoplasmic deadenylase complex, is known to be required for the cell wall integrity (CWI) pathway in the budding yeast Saccharomyces cerevisiae.
Xia Li +6 more
doaj +1 more source
Tex13a Optimizes Sperm Motility via Its Potential Roles in mRNA Turnover
Frontiers in Cell and Developmental Biology, 2021 mRNAs have been found to undergo substantial selective degradation during the late stages of spermiogenesis. However, the mechanisms regulating this biological process are unknown. In this report, we have identified Tex13a, a spermatid-specific gene that
Yinchuan Li +10 more
doaj +1 more source