Results 21 to 30 of about 22,512 (231)

Alternative splicing of CNOT7 diversifies CCR4–NOT functions [PDF]

Nucleic Acids Research, 2017
The CCR4-associated factor CAF1, also called CNOT7, is a catalytic subunit of the CCR4-NOT complex, which has been implicated in all aspects of the mRNA life cycle, from mRNA synthesis in the nucleus to degradation in the cytoplasm. In human cells, alternative splicing of the CNOT7 gene yields a second CNOT7 transcript leading to the formation of a ...
Chapat, Clément, Chettab, Kamel, Simonet, Pierre, Wang, Peng, de La Grange, Pierre, Le Romancer, Muriel, Corbo, Laura   +6 more
openaire   +4 more sources

The Ccr4-Not Complex Regulates Skn7 through Srb10 Kinase [PDF]

Eukaryotic Cell, 2007
ABSTRACT The Ccr4-Not complex is a multifunctional regulatory platform composed of nine subunits that controls diverse cellular events including mRNA degradation, protein ubiquitination, and transcription. In this study, we identified the yeast Saccharomyces cerevisiae osmotic and oxidative stress ...
Lenssen, Eve, Azzouz, Nowel, Michel, Agnès, Landrieux, Emilie, Collart, Martine   +4 more
openaire   +3 more sources

The Ccr4-Not complex regulates TORC1 signaling and mitochondrial metabolism by promoting vacuole V-ATPase activity.

PLoS Genetics, 2020
The Ccr4-Not complex functions as an effector of multiple signaling pathways that control gene transcription and mRNA turnover. Consequently, Ccr4-Not contributes to a diverse array of processes, which includes a significant role in cell metabolism.
Hongfeng Chen, P Winston Miller, Daniel L Johnson, R Nicholas Laribee   +3 more
doaj   +1 more source

miRNAs as Influencers of Cell-Cell Communication in Tumor Microenvironment [PDF]

, 2020
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level, inducing the degradation of the target mRNA or translational repression.
Conti, Ilaria, Laface, Ilaria, Milani, Daniela, Neri, Luca M, Rimondi, Erika, Simioni, Carolina, Varano, Gabriele   +6 more
core   +1 more source

Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice

Journal of Pharmacological Sciences, 2023
Increasing evidence indicates that immune abnormalities are associated with the pathogenesis of depression. CCR4 is a chemokine receptor that regulates regulatory T cell (Treg) and Th17 cell migration.
Yuta Hara, Tatsuma Honzawa, Moeka Kitagawa, Ritsuki Sano, Kazuhiko Matsuo, Takashi Nakayama   +5 more
doaj   +1 more source

Interaction of NANOS2 and NANOS3 with different components of the CNOT complex may contribute to the functional differences in mouse male germ cells

Biology Open, 2014
NANOS2 and NANOS3 belong to the Nanos family of proteins that contain a conserved zinc finger domain, which consists of two consecutive CCHC-type zinc finger motifs, and contribute to germ cell development in mice.
Atsushi Suzuki, Yuki Niimi, Yumiko Saga
doaj   +1 more source

The multifunctional Ccr4–Not complex directly promotes transcription elongation [PDF]

Genes & Development, 2011
The Ccr4–Not complex has been implicated in the control of multiple steps of mRNA metabolism; however, its functions in transcription remain ambiguous. The discovery that Ccr4/Pop2 is the major cytoplasmic mRNA deadenylase and the detection of Not proteins within mRNA processing bodies have raised questions about the roles of the Ccr4–Not complex in ...
Jennifer A, Kruk, Arnob, Dutta, Jianhua, Fu, David S, Gilmour, Joseph C, Reese   +4 more
openaire   +2 more sources

The Ccr4-Not Complex: Architecture and Structural Insights

Subcellular Biochemistry, 2017
The Ccr4-Not complex is an essential multi-subunit protein complex that plays a fundamental role in eukaryotic mRNA metabolism and has a multitude of different roles that impact eukaryotic gene expression . It has a conserved core of three Not proteins, the Ccr4 protein, and two Ccr4 associated factors, Caf1 and Caf40.
Collart, Martine, Panasenko, Olesya
openaire   +4 more sources

Multifunctional roles of the mammalian CCR4-NOT complex in physiological phenomena

Frontiers in Genetics, 2014
The CCR4-NOT complex serves as one of the major deadenylases of eukaryotes. Although it was originally identified and characterized in yeast, recent studies have revealed that the CCR4-NOT complex also exerts important functions in mammals, including ...
Yo-Taro eShirai, Toru eSuzuki, Masahiro eMorita, Masahiro eMorita, Akinori eTakahashi, Tadashi eYamamoto   +5 more
doaj   +1 more source

Identification of ebs1, lsm6 and nup159 as suppressors of spt10 effects at ADH2 in Saccharomyces cerevisiae suggests post-transcriptional defects affect mRNA synthesis [PDF]

, 2012
Suppression of the effects of an spt10 mutation on ADH2 expression is a phenotype shared by a small number of genes whose protein products are either components of the CCR4-NOT complex required for mRNA deadenylation and degradation (CCR4, CAF1, NOT4) or
Anderson, Bradley, Denis, Clyde L., May, Carrie Ann   +2 more
core   +3 more sources