Results 1 to 10 of about 19,147 (116)

Diphtheria‐toxin based anti‐human CCR4 immunotoxin for targeting human CCR4+ cells in vivo

Molecular Oncology, 2015
CC chemokine receptor 4 (CCR4) has attracted much attention as a promising therapeutic drug target for CCR4+ tumor cells and Tregs. CCR4 is expressed on some tumor cells such as T‐cell acute lymphoblastic leukemia (ALL), adult T‐cell leukemia/lymphoma ...
Zhaohui Wang, Huiping Zhang, Christene A Huang   +2 more
exaly   +2 more sources

The Regulatory Properties of the Ccr4–Not Complex

Cells, 2020
The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression.
Nafiseh Chalabi Hagkarim, Roger J. Grand
exaly   +3 more sources

C‐C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The dysregulated immune system, which drives chronic vascular inflammation and remodeling, plays a critical role in the pathogenesis of abdominal aortic aneurysm (AAA).
Aga Krisnanda, Naoto Sasaki, Toru Tanaka, Ken Ito, Takuo Emoto, Takeshi Yoshida, Hilman Zulkifli Amin, Sayo Horibe, Gusty Rizky Teguh Ryanto, Noriaki Emoto, Tomoya Yamashita, Ken‐ichi Hirata, Kazuhiko Matsuo, Takashi Nakayama, Yoshiyuki Rikitake   +14 more
doaj   +2 more sources

CCR4 Blockade Diminishes Intratumoral Macrophage Recruitment and Augments Survival of Syngeneic Pancreatic Cancer-Bearing Mice

Biomedicines, 2023
Pancreatic cancer is known for its tumor microenvironment (TME), which is rich in stromal and immune cells supporting cancer growth and therapy resistance.
Aydar Khabipov, Dung Nguyen Trung, Julia van der Linde, Lea Miebach, Maik Lenz, Felix Erne, Wolfram von Bernstorff, Tobias Schulze, Stephan Kersting, Sander Bekeschus, Lars Ivo Partecke   +10 more
doaj   +1 more source

CCR4‐IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T‐cell lymphoma in a mouse CTCL model

FEBS Open Bio, 2023
Cutaneous T‐cell lymphoma (CTCL) encompasses two main subtypes: mycosis fungoides and Sezary syndrome. Global response rates for the systemic treatment of mycosis fungoides and Sezary syndrome are approximately 30%, and none of these treatments are ...
Zhaohui Wang, Jihong Ma, Huiping Zhang, Rashmi Ramakrishna, Danielle Mintzlaff, David W. Mathes, Elizabeth A. Pomfret, M. Scott Lucia, Dexiang Gao, Bradley M. Haverkos, Zhirui Wang   +10 more
doaj   +1 more source

FOXP3/HAT1 Axis Controls Treg Infiltration in the Tumor Microenvironment by Inducing CCR4 Expression in Breast Cancer

Frontiers in Immunology, 2022
Infiltrating T-regulatory cells in the tumor microenvironment is a key impediment to immunotherapy and is linked to a poor prognosis. We found that tumor-infiltrating Tregs express a higher expression of the chemokine receptor CCR4 than peripheral Tregs ...
Tania Sarkar, Subhanki Dhar, Dwaipayan Chakraborty, Subhadip Pati, Sayantan Bose, Abir K. Panda, Udit Basak, Sourio Chakraborty, Sumon Mukherjee, Aharna Guin, Kuladip Jana, Diptendra K. Sarkar, Gaurisankar Sa   +12 more
doaj   +1 more source

Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4

Journal for ImmunoTherapy of Cancer, 2020
Background Checkpoint inhibitors (CPIs) such as anti-PD(L)-1 and anti-CTLA-4 antibodies have resulted in unprecedented rates of antitumor responses and extension of survival of patients with a variety of cancers.
Brian Wong, Dirk G Brockstedt, Lisa A Marshall, Sachie Marubayashi, Aparna Jorapur, Scott Jacobson, Mikhail Zibinsky, Omar Robles, Dennis Xiaozhou Hu, Jeffrey J Jackson, Deepa Pookot, Jerick Sanchez, Martin Brovarney, Angela Wadsworth, David Chian, David Wustrow, Paul D Kassner, Gene Cutler, Oezcan Talay   +18 more
doaj   +1 more source

Bispecific human IL2‐CCR4 immunotoxin targets human cutaneous T‐cell lymphoma

Molecular Oncology, 2020
The majority of clinically diagnosed cutaneous T‐cell lymphomas (CTCL) highly express the cell‐surface markers CC chemokine receptor 4 (CCR4) and/or CD25.
Haoyu Wang, Zhaohui Wang, Huiping Zhang, Zeng Qi, Ariel C. Johnson, David Mathes, Elizabeth A. Pomfret, Erin Rubin, Christene A. Huang, Zhirui Wang   +9 more
doaj   +1 more source

Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice

Journal of Pharmacological Sciences, 2023
Increasing evidence indicates that immune abnormalities are associated with the pathogenesis of depression. CCR4 is a chemokine receptor that regulates regulatory T cell (Treg) and Th17 cell migration.
Yuta Hara, Tatsuma Honzawa, Moeka Kitagawa, Ritsuki Sano, Kazuhiko Matsuo, Takashi Nakayama   +5 more
doaj   +1 more source

Evaluation of lymphocyte migration to induced paederus dermatitis: An experimental study in rats

Indian Journal of Dermatology, 2019
Background: Paederus dermatitis (PD) is a blistering disorder that is caused by a small insect of the genus Paederus, especially Paederus fuscipes. This study aimed to investigate the reaction of the adaptive immune system regarding the recruitment of ...
Fereshteh Hosseini Valiki, Mohammad Mahdi Mohammadi, Abolghasem Ajami, Alireza Khalatbari, Farzad Motevalli Haghi   +4 more
doaj   +1 more source