Results 1 to 10 of about 19,867 (155)
Diphtheria-toxin based anti-human CCR4 immunotoxin for targeting human CCR4+ cells in vivo
Molecular Oncology, 2015 CC chemokine receptor 4 (CCR4) has attracted much attention as a promising therapeutic drug target for CCR4+ tumor cells and Tregs. CCR4 is expressed on some tumor cells such as T‐cell acute lymphoblastic leukemia (ALL), adult T‐cell leukemia/lymphoma ...
Christene A Huang +2 more
exaly +2 more sources
The Regulatory Properties of the Ccr4–Not Complex
Cells, 2020 The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression.
Nafiseh Chalabi Hagkarim, Roger J. Grand
exaly +3 more sources
Biomedicines, 2023 Pancreatic cancer is known for its tumor microenvironment (TME), which is rich in stromal and immune cells supporting cancer growth and therapy resistance.
Aydar Khabipov +10 more
doaj +1 more source
Frontiers in Immunology, 2022 Infiltrating T-regulatory cells in the tumor microenvironment is a key impediment to immunotherapy and is linked to a poor prognosis. We found that tumor-infiltrating Tregs express a higher expression of the chemokine receptor CCR4 than peripheral Tregs ...
Tania Sarkar +12 more
doaj +1 more source
FEBS Open Bio, 2023 Cutaneous T‐cell lymphoma (CTCL) encompasses two main subtypes: mycosis fungoides and Sezary syndrome. Global response rates for the systemic treatment of mycosis fungoides and Sezary syndrome are approximately 30%, and none of these treatments are ...
Zhaohui Wang +10 more
doaj +1 more source
Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4
Journal for ImmunoTherapy of Cancer, 2020 Background Checkpoint inhibitors (CPIs) such as anti-PD(L)-1 and anti-CTLA-4 antibodies have resulted in unprecedented rates of antitumor responses and extension of survival of patients with a variety of cancers.
Brian Wong +18 more
doaj +1 more source
Bispecific human IL2‐CCR4 immunotoxin targets human cutaneous T‐cell lymphoma
Molecular Oncology, 2020 The majority of clinically diagnosed cutaneous T‐cell lymphomas (CTCL) highly express the cell‐surface markers CC chemokine receptor 4 (CCR4) and/or CD25.
Haoyu Wang +9 more
doaj +1 more source
Aggravation of lipopolysaccharide-induced depressive-like behavior in CCR4-deficient mice
Journal of Pharmacological Sciences, 2023 Increasing evidence indicates that immune abnormalities are associated with the pathogenesis of depression. CCR4 is a chemokine receptor that regulates regulatory T cell (Treg) and Th17 cell migration.
Yuta Hara +5 more
doaj +1 more source
Evaluation of lymphocyte migration to induced paederus dermatitis: An experimental study in rats
Indian Journal of Dermatology, 2019 Background: Paederus dermatitis (PD) is a blistering disorder that is caused by a small insect of the genus Paederus, especially Paederus fuscipes. This study aimed to investigate the reaction of the adaptive immune system regarding the recruitment of ...
Fereshteh Hosseini Valiki +4 more
doaj +1 more source
Small Molecule CCR4 Antagonists Protect Mice from Aspergillus Infection and Allergy
Biomolecules, 2021 The ability to regulate the recruitment of immune cells makes chemokines and their receptors attractive drug targets in many inflammatory diseases. Based on its preferential expression on T helper type 2 (Th2) cells, C-C chemokine receptor type 4 (CCR4 ...
Silvia Bozza +6 more
doaj +1 more source