Results 11 to 20 of about 34,716 (235)
Diphtheria‐toxin based anti‐human CCR4 immunotoxin for targeting human CCR4+ cells in vivo [PDF]
Molecular Oncology, 2015 CC chemokine receptor 4 (CCR4) has attracted much attention as a promising therapeutic drug target for CCR4+ tumor cells and Tregs. CCR4 is expressed on some tumor cells such as T‐cell acute lymphoblastic leukemia (ALL), adult T‐cell leukemia/lymphoma ...
Zhaohui Wang +8 more
doaj +3 more sources
Haematologica, 2018 Histone deacetylase inhibitors are promising agents for various T-cell lymphomas, including cutaneous T-cell lymphoma, peripheral T-cell lymphoma, and adult T-cell lymphoma/leukemia. CCR4 is an important therapeutic target molecule because mogamulizumab,
Akihiro Kitadate +6 more
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The Regulatory Properties of the Ccr4–Not Complex [PDF]
Cells, 2020 The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression.
Nafiseh Chalabi Hagkarim, Roger J. Grand
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CCR4 drives ATLL jail break [PDF]
Journal of Experimental Medicine, 2014 ![Figure][1] Insight from Kevin Shannon Adult T cell leukemia/lymphoma (ATLL), caused by human T cell lymphotropic virus 1 (HTLV-1), is an aggressive cancer that is refractory to current therapies.
Shannon, Kevin, Shannon, KM
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Ccr4–Not complex reduces transcription efficiency in heterochromatin [PDF]
Nucleic Acids Research, 2021 Abstract Heterochromatic silencing is thought to occur through a combination of transcriptional silencing and RNA degradation, but the relative contribution of each pathway is not known. In this study, we analyzed RNA Polymerase II (RNA Pol II) occupancy and levels of nascent and steady-state RNA in different mutants of ...
Pablo Monteagudo-Mesas +5 more
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SPT5 affects the rate of mRNA degradation and physically interacts with CCR4 but does not control mRNA deadenylation [PDF]
, 2011 The CCR4-NOT complex has been shown to have multiple roles in mRNA metabolism, including that of transcriptional elongation, mRNA transport, and nuclear exosome function, but the primary function of CCR4 and CAF1 is in the deadenylation and degradation ...
Chiang, Yueh-Chin +4 more
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Identification of ebs1, lsm6 and nup159 as suppressors of spt10 effects at ADH2 in Saccharomyces cerevisiae suggests post-transcriptional defects affect mRNA synthesis [PDF]
, 2012 Suppression of the effects of an spt10 mutation on ADH2 expression is a phenotype shared by a small number of genes whose protein products are either components of the CCR4-NOT complex required for mRNA deadenylation and degradation (CCR4, CAF1, NOT4) or
Anderson, Bradley +2 more
core +3 more sources
Immunopathogenesis of lymphoma: Focus on CCR4 [PDF]
Cancer Science, 2010 Evading immune surveillance is one of the common hallmarks of cancer. Herein we describe two major evasion mechanisms in lymphoma, focusing on regulatory T (Treg) cells and C‐C chemokine receptor 4 (CCR4) expressed on these cells. First, the tumor cells themselves function as Treg cells, characterized by expression of CCR4, contributing to tumor ...
Takashi, Ishida, Ryuzo, Ueda
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eLife, 2023 Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T cell lineage, thus preventing autoimmunity. To undergo central tolerance, thymocytes must enter the medulla to test their T-cell receptors (TCRs) for ...
Yu Li +5 more
doaj +1 more source
Lead identification and structure-activity relationships of heteroarylpyrazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists [PDF]
, 2014 A knowledge-based library of aryl 2,3-dichlorophenylsulfonamides was synthesised and screened as human CCR4 antagonists, in order to identify a suitable hit for the start of a lead-optimisation programme.
Copley, R.C.B. +4 more
core +1 more source