Evaluation of lymphocyte migration to induced paederus dermatitis: An experimental study in rats
Indian Journal of Dermatology, 2019 Background: Paederus dermatitis (PD) is a blistering disorder that is caused by a small insect of the genus Paederus, especially Paederus fuscipes. This study aimed to investigate the reaction of the adaptive immune system regarding the recruitment of ...
Fereshteh Hosseini Valiki +4 more
doaj +1 more source
The CCR4-NOT complex physically and functionally interacts with TRAMP and the nuclear exosome. [PDF]
PLoS ONE, 2009 BACKGROUND:Ccr4-Not is a highly conserved multi-protein complex consisting in yeast of 9 subunits, including Not5 and the major yeast deadenylase Ccr4.
Nowel Azzouz +3 more
doaj +1 more source
Humanized anti CCR4 antibody KW0761 targets HTLV-1 infected CD4+ CCR4+ and CD8+CCR4+ T cells to treat HAM/TSP [PDF]
Retrovirology, 2015 Human T-lymphotropic virus type I (HTLV-1) can cause HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukemia/lymphoma (ATL). Since the prognosis for HAM/TSP patients is extremely poor, there is a strong demand for a novel therapeutic strategy, especially one which would effectively reduce HTLV-1 proviral load ...
Yamano, Yoshihisa +11 more
openaire +1 more source
Ccr4-not regulates RNA polymerase I transcription and couples nutrient signaling to the control of ribosomal RNA biogenesis. [PDF]
PLoS Genetics, 2015 Ribosomal RNA synthesis is controlled by nutrient signaling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway. mTORC1 regulates ribosomal RNA expression by affecting RNA Polymerase I (Pol I)-dependent transcription of the ribosomal ...
R Nicholas Laribee +3 more
doaj +1 more source
Small Molecule CCR4 Antagonists Protect Mice from Aspergillus Infection and Allergy
Biomolecules, 2021 The ability to regulate the recruitment of immune cells makes chemokines and their receptors attractive drug targets in many inflammatory diseases. Based on its preferential expression on T helper type 2 (Th2) cells, C-C chemokine receptor type 4 (CCR4 ...
Silvia Bozza +6 more
doaj +1 more source
Smoking affects gene expression in blood of patients with ischemic stroke. [PDF]
, 2019 ObjectiveThough cigarette smoking (CS) is a well-known risk factor for ischemic stroke (IS), there is no data on how CS affects the blood transcriptome in IS patients.MethodsWe recruited IS-current smokers (IS-SM), IS-never smokers (IS-NSM), control ...
Ander, Bradley P +6 more
core +2 more sources
Lung dendritic cells imprint T cell lung homing and promote lung immunity through the chemokine receptor CCR4 [PDF]
, 2014 T cell trafficking into the lung is critical for lung immunity, but the mechanisms that mediate T cell lung homing are not well understood. Here, we show that lung dendritic cells (DCs) imprint T cell lung homing, as lung DC–activated T cells traffic ...
Luster, Andrew D. +2 more
core +1 more source
Journal of Pharmacological Sciences, 2018 CCR4 is a major chemokine receptor expressed by Treg cells that downregulate immune responses. Here, we investigated the role of CCR4-mediated Treg cell recruitment in antigen-specific immune responses.
Shinya Yamamoto +8 more
doaj +1 more source
PLoS Genetics, 2020 The Ccr4-Not complex functions as an effector of multiple signaling pathways that control gene transcription and mRNA turnover. Consequently, Ccr4-Not contributes to a diverse array of processes, which includes a significant role in cell metabolism.
Hongfeng Chen +3 more
doaj +1 more source
Multifunctional roles of the mammalian CCR4-NOT complex in physiological phenomena
Frontiers in Genetics, 2014 The CCR4-NOT complex serves as one of the major deadenylases of eukaryotes. Although it was originally identified and characterized in yeast, recent studies have revealed that the CCR4-NOT complex also exerts important functions in mammals, including ...
Yo-Taro eShirai +5 more
doaj +1 more source