Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4+ Treg in nonhuman primates [PDF]
Molecular Oncology, 2018 Recently, we have developed a diphtheria toxin‐based recombinant anti‐human CCR4 immunotoxin for targeting CCR4+ tumors and Tregs. In this study, we further optimized the dosing schedule for improved CCR4+ Treg depletion.
Zhaohui Wang +10 more
doaj +2 more sources
Immunopathogenesis of lymphoma: Focus on CCR4 [PDF]
Cancer Science, 2010 Evading immune surveillance is one of the common hallmarks of cancer. Herein we describe two major evasion mechanisms in lymphoma, focusing on regulatory T (Treg) cells and C‐C chemokine receptor 4 (CCR4) expressed on these cells. First, the tumor cells themselves function as Treg cells, characterized by expression of CCR4, contributing to tumor ...
Takashi, Ishida, Ryuzo, Ueda
openaire +2 more sources
Ccr4–Not complex reduces transcription efficiency in heterochromatin [PDF]
Nucleic Acids Research, 2021 Abstract Heterochromatic silencing is thought to occur through a combination of transcriptional silencing and RNA degradation, but the relative contribution of each pathway is not known. In this study, we analyzed RNA Polymerase II (RNA Pol II) occupancy and levels of nascent and steady-state RNA in different mutants of ...
Pablo Monteagudo-Mesas +5 more
openaire +2 more sources
Role of the chemokine receptors CCR1, CCR2 and CCR4 in the pathogenesis of experimental dengue infection in mice [PDF]
, 2010 Dengue virus (DENV), a mosquito-borne flavivirus, is a public health problem in many tropical countries. Recent clinical data have shown an association between levels of different chemokines in plasma and severity of dengue.
Mauro M Teixeira +30 more
core +1 more source
Ccr4-Not complex components genetically interact with and and play a role in transcription elongation [PDF]
, 2011 Copyright information:Taken from "Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex"Nucleic Acids Research 2007;35(7):2428-2439.Published online 28 Mar 2007PMCID:PMC1874646.© 2007 The Author(s) () Tetrad ...
Akiko Inagaki (30053) +4 more
core +1 more source
The role of TNRC6 proteins in gene silencing [PDF]
, 2013 Proteins of the GW182 family have recently emerged as key players in miRNAmediated gene silencing. They have been shown to interact with Argonaute proteins, components of the RISC and are assumed to mediate the repression in metazoa. Three paralogues are
Zipprich, Jakob Theophil
core +1 more source
eLife, 2023 Central tolerance ensures autoreactive T cells are eliminated or diverted to the regulatory T cell lineage, thus preventing autoimmunity. To undergo central tolerance, thymocytes must enter the medulla to test their T-cell receptors (TCRs) for ...
Yu Li +5 more
doaj +1 more source
The CCR4-NOT complex physically and functionally interacts with TRAMP and the nuclear exosome. [PDF]
PLoS ONE, 2009 BACKGROUND:Ccr4-Not is a highly conserved multi-protein complex consisting in yeast of 9 subunits, including Not5 and the major yeast deadenylase Ccr4.
Nowel Azzouz +3 more
doaj +1 more source
Ccr4-not regulates RNA polymerase I transcription and couples nutrient signaling to the control of ribosomal RNA biogenesis. [PDF]
PLoS Genetics, 2015 Ribosomal RNA synthesis is controlled by nutrient signaling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway. mTORC1 regulates ribosomal RNA expression by affecting RNA Polymerase I (Pol I)-dependent transcription of the ribosomal ...
R Nicholas Laribee +3 more
doaj +1 more source
Small Molecule CCR4 Antagonists Protect Mice from Aspergillus Infection and Allergy
Biomolecules, 2021 The ability to regulate the recruitment of immune cells makes chemokines and their receptors attractive drug targets in many inflammatory diseases. Based on its preferential expression on T helper type 2 (Th2) cells, C-C chemokine receptor type 4 (CCR4 ...
Silvia Bozza +6 more
doaj +1 more source