Results 41 to 50 of about 21,976 (228)

Trametinib improves Treg selectivity of anti-CCR4 antibody by regulating CCR4 expression in CTLs in oral squamous cell carcinoma

Scientific Reports, 2022
Regulatory T-cells (Tregs) play a major role in suppressing anti-tumor immune responses. Mogamulizumab, an anti-CC chemokine receptor type 4 (CCR4) monoclonal antibody, depletes effector Tregs (eTregs). However, the clinical efficacy of mogamulizumab was
Shoya Ono, Susumu Suzuki, Yutaro Kondo, Ikuko Okubo, Mitsuo Goto, Tetsuya Ogawa, Hidefumi Kato, Hideaki Ito, Taishi Takahara, Akira Satou, Toyonori Tsuzuki, Kazuhiro Yoshikawa, Toru Nagao, Ryuzo Ueda   +13 more
doaj   +1 more source

CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction

Frontiers in Endocrinology, 2023
Background/AimsChemokines are known to play critical roles mediating inflammation in many pathophysiological processes. The aim of this study was to investigate the role of chemokine receptor CCR4 and its ligands CCL17 and CCL22 in human morbid obesity ...
Luisa Hueso, Patrice Marques, Brenda Morant, Herminia Gonzalez-Navarro, Herminia Gonzalez-Navarro, Herminia Gonzalez-Navarro, Joaquin Ortega, Joaquin Ortega, José T. Real, José T. Real, José T. Real, María J Sanz, María J Sanz, María J Sanz, Laura Piqueras, Laura Piqueras, Laura Piqueras   +16 more
doaj   +1 more source

Supplementary Material for: Internalization of CCR4 and Inhibition of Chemotaxis by K777, a Potent and Selective CCR4 Antagonist [PDF]

, 2017
CC chemokine receptor 4 (CCR4) is a G protein-coupled receptor that regulates the chemotaxis of Th2 lymphocytes, which are key players in allergic diseases. K777 is a small compound identified in a binding assay using a CCR4 ligand, CCL17. K777 inhibited
Komai M. (4138690), Sato T. (3363755), Miki I. (4138684), Yano H. (4138687), Miyama M. (4138696), Ohshima E. (4138678), Asai A. (4138681), Iwase M. (4138693)   +7 more
core   +1 more source

CHEMOKINE RECEPTORS AT DISTINCT DIFFERENTIATION STAGES OF T-HELPERS FROM PERIPHERAL BLOOD

Медицинская иммунология, 2016
Expression of chemokine receptors (CCR4, CCR6, CXCR3 and CXCR5) on T-helper (Th) cells at various levels of differentiation in a group of healthy volunteers (n = 52) was assessed on the basis of CD45RA and CD62L expression, using the eight-color flow ...
I. V. Kudryavtsev, A. G. Borisov, I. I. Krobinets, A. A. Savchenko, M. K. Serebriakova, Areg A. Totolian   +5 more
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CCR4, a RNA decay factor, is hijacked by a plant cytorhabdovirus phosphoprotein to facilitate virus replication

eLife, 2020
Carbon catabolite repression 4 (CCR4) is a conserved mRNA deadenylase regulating posttranscriptional gene expression. However, regulation of CCR4 in virus infections is less understood.
Zhen-Jia Zhang, Qiang Gao, Xiao-Dong Fang, Zhi-Hang Ding, Dong-Min Gao, Wen-Ya Xu, Qing Cao, Ji-Hui Qiao, Yi-Zhou Yang, Chenggui Han, Ying Wang, Xuefeng Yuan, Dawei Li, Xian-Bing Wang   +13 more
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Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after ICH in mice

Journal of Neuroinflammation, 2021
Background Intracerebral hemorrhage (ICH), a devastating subtype of stroke, is associated with high mortality and morbidity. Neuroinflammation is an important factor leading to ICH-induced neurological injuries.
Shuixiang Deng, Peng Jin, Prativa Sherchan, Shengpeng Liu, Yuhui Cui, Lei Huang, John H. Zhang, Ye Gong, Jiping Tang   +8 more
doaj   +1 more source

Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex

Frontiers in Immunology, 2021
Development of lymphocytes is precisely regulated by various mechanisms. In addition to transcriptional rates, post-transcriptional regulation of mRNA abundance contributes to differentiation of lymphocytes. mRNA decay is a post-transcriptional mechanism
Taishin Akiyama, Taishin Akiyama, Tadashi Yamamoto   +2 more
doaj   +1 more source

The multifunctional Ccr4–Not complex directly promotes transcription elongation [PDF]

, 2011
The Ccr4–Not complex has been implicated in the control of multiple steps of mRNA metabolism; however, its functions in transcription remain ambiguous.
Arnob Dutta, David S. Gilmour, Jennifer A. Kruk, Jianhua Fu, Joseph C. Reese   +4 more
core   +1 more source

infection [PDF]

, 2023
Unlike most RNA and DNA viruses that broadly stimulate mRNA decay and interfere with host gene expression, human cytomegalovirus (HCMV) extensively remodels the host translatome without producing an mRNA decay enzyme.
Riccio, Sofia, Ikshitaa Dinesh, Grande, Rebecca, Rebecca Grande, Sofia Riccio, Gerlof Sebastiaan Winkler, Daniel P Depledge, Burgess, Hannah M, Dinesh, Ikshitaa, Depledge, Daniel P, Mohr, Ian, Winkler, Gerlof Sebastiaan, Hannah M Burgess, Ian Mohr   +13 more
core   +2 more sources

Spotlight on Mogamulizumab-Kpkc for Use in Adults with Relapsed or Refractory Mycosis Fungoides or Sézary Syndrome: Efficacy, Safety, and Patient Selection

Drug Design, Development and Therapy, 2020
Amanda L Blackmon,1 Lauren Pinter-Brown1,2 1Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, Irvine, CA, USA; 2Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA ...
Blackmon AL, Pinter-Brown L
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