Results 41 to 50 of about 23,452 (228)

Twin Promotes the Maintenance and Differentiation of Germline Stem Cell Lineage through Modulation of Multiple Pathways

Cell Reports, 2015
The central question in stem cell regulation is how the balance between self-renewal and differentiation is controlled at the molecular level. This study uses germline stem cells (GSCs) in the Drosophila ovary to demonstrate that the Drosophila CCR4 ...
Ziwen Fu, Cuiyun Geng, Hui Wang, Zhihao Yang, Changjiang Weng, Hua Li, Lamei Deng, Luping Liu, Nan Liu, Jianquan Ni, Ting Xie   +10 more
doaj   +1 more source

CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction

Frontiers in Endocrinology, 2023
Background/AimsChemokines are known to play critical roles mediating inflammation in many pathophysiological processes. The aim of this study was to investigate the role of chemokine receptor CCR4 and its ligands CCL17 and CCL22 in human morbid obesity ...
Luisa Hueso, Patrice Marques, Brenda Morant, Herminia Gonzalez-Navarro, Herminia Gonzalez-Navarro, Herminia Gonzalez-Navarro, Joaquin Ortega, Joaquin Ortega, José T. Real, José T. Real, José T. Real, María J Sanz, María J Sanz, María J Sanz, Laura Piqueras, Laura Piqueras, Laura Piqueras   +16 more
doaj   +1 more source

Dose-dependent binding of anti-CCR4 IgG antibodies to CCR4⁺ and CCR4⁻ cell lines.

, 2014
Different concentrations of 17G, 9E and KM3060var antibodies were tested in flow cytometry for binding to avian DT40 cells stably transfected with human CCR4 (a), to human HEK-293 cells transiently transfected with human CCR4 (b) or to human T-cell ...
Solène Géraudie (607007), Lavinia Gunnarsson (607006), Sergej M. Kiprijanov (607011), Urs B. Hagemann (607005), Herald Reiersen (6771), Remko A. Griep (607009), Ulrike Scheffler (607008), Alexander R. Duncan (607010)   +7 more
core   +1 more source

CCR4+ Skin-Tropic Phenotype as a Feature of Central Memory CD8+ T Cells in Healthy Subjects and Psoriasis Patients

Frontiers in Immunology, 2020
The chemokine receptor CCR4 has emerged as a skin-homing molecule important for the migration of T cells from the blood to the dermis. From our previous data on psoriasis patients, CCR4+ memory T cells emerged as a putative recirculating population ...
Fabio Casciano, Marco Diani, Andrea Altomare, Francesca Granucci, Paola Secchiero, Giuseppe Banfi, Giuseppe Banfi, Eva Reali   +7 more
doaj   +1 more source

A degradatory fate for CCR4 suggests a primary role in Th2 inflammation [PDF]

, 2020
CCR4 is the sole receptor for the chemokines CCL22 and CCL17. Clinical studies of asthmatic airways have shown levels of both ligands and CCR4+ Th2 cells to be elevated, suggestive of a role in disease.
Solari, Roberto, Phillips, RM, Pease, James, Solari, R, Patel, Pallavi, Viney, JM, Pease, JE, Anderson, CA, Anderson, Caroline, Viney, Jonathan, Phillips, Rhian, Patel, P   +11 more
core   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after ICH in mice

Journal of Neuroinflammation, 2021
Background Intracerebral hemorrhage (ICH), a devastating subtype of stroke, is associated with high mortality and morbidity. Neuroinflammation is an important factor leading to ICH-induced neurological injuries.
Shuixiang Deng, Peng Jin, Prativa Sherchan, Shengpeng Liu, Yuhui Cui, Lei Huang, John H. Zhang, Ye Gong, Jiping Tang   +8 more
doaj   +1 more source

Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex

Frontiers in Immunology, 2021
Development of lymphocytes is precisely regulated by various mechanisms. In addition to transcriptional rates, post-transcriptional regulation of mRNA abundance contributes to differentiation of lymphocytes. mRNA decay is a post-transcriptional mechanism
Taishin Akiyama, Taishin Akiyama, Tadashi Yamamoto   +2 more
doaj   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

CCR4-bearing T cells participate in autoimmune diabetes [PDF]

, 2002
Chemokine receptor expression is exquisitely regulated on T cell subsets during the course of their migration to inflammatory sites. In the present study we demonstrate that CCR4 expression marks a pathogenic population of autoimmune T cells.
Mary M. Cleary, David Chantry, Nora Sarvetnick, Sarvetnick, Nora, Howard S. Fox, Kim, Soon H., Fox, Howard S., ICOS Coporation, Soon H. Kim, Cleary, Mary M.   +9 more
core   +1 more source