Results 31 to 40 of about 23,452 (228)

The structural basis for deadenylation by the CCR4-NOT complex [PDF]

Protein & Cell, 2010
The CCR4-NOT complex is a highly conserved, multifunctional machinery controlling mRNA metabolism. Its components have been implicated in several aspects of mRNA and protein expression, including transcription initiation, elongation, mRNA degradation, ubiquitination, and protein modification.
Mark, Bartlam, Tadashi, Yamamoto
openaire   +2 more sources

Different Regulations of ROM2 and LRG1 Expression by Ccr4, Pop2, and Dhh1 in the Saccharomyces cerevisiae Cell Wall Integrity Pathway

mSphere, 2016
Ccr4, a component of the Ccr4-Not cytoplasmic deadenylase complex, is known to be required for the cell wall integrity (CWI) pathway in the budding yeast Saccharomyces cerevisiae.
Xia Li, Tetsuro Ohmori, Kaoru Irie, Yuichi Kimura, Yasuyuki Suda, Tomoaki Mizuno, Kenji Irie   +6 more
doaj   +1 more source

Trametinib improves Treg selectivity of anti-CCR4 antibody by regulating CCR4 expression in CTLs in oral squamous cell carcinoma

Scientific Reports, 2022
Regulatory T-cells (Tregs) play a major role in suppressing anti-tumor immune responses. Mogamulizumab, an anti-CC chemokine receptor type 4 (CCR4) monoclonal antibody, depletes effector Tregs (eTregs). However, the clinical efficacy of mogamulizumab was
Shoya Ono, Susumu Suzuki, Yutaro Kondo, Ikuko Okubo, Mitsuo Goto, Tetsuya Ogawa, Hidefumi Kato, Hideaki Ito, Taishi Takahara, Akira Satou, Toyonori Tsuzuki, Kazuhiro Yoshikawa, Toru Nagao, Ryuzo Ueda   +13 more
doaj   +1 more source

Ccr4–Not complex reduces transcription efficiency in heterochromatin [PDF]

Nucleic Acids Research, 2021
Abstract Heterochromatic silencing is thought to occur through a combination of transcriptional silencing and RNA degradation, but the relative contribution of each pathway is not known. In this study, we analyzed RNA Polymerase II (RNA Pol II) occupancy and levels of nascent and steady-state RNA in different mutants of ...
Pablo Monteagudo-Mesas, Cornelia Brönner, Parastou Kohvaei, Haris Amedi, Stefan Canzar, Mario Halic   +5 more
openaire   +2 more sources

CHEMOKINE RECEPTORS AT DISTINCT DIFFERENTIATION STAGES OF T-HELPERS FROM PERIPHERAL BLOOD

Медицинская иммунология, 2016
Expression of chemokine receptors (CCR4, CCR6, CXCR3 and CXCR5) on T-helper (Th) cells at various levels of differentiation in a group of healthy volunteers (n = 52) was assessed on the basis of CD45RA and CD62L expression, using the eight-color flow ...
I. V. Kudryavtsev, A. G. Borisov, I. I. Krobinets, A. A. Savchenko, M. K. Serebriakova, Areg A. Totolian   +5 more
doaj   +1 more source

CCR4, a RNA decay factor, is hijacked by a plant cytorhabdovirus phosphoprotein to facilitate virus replication

eLife, 2020
Carbon catabolite repression 4 (CCR4) is a conserved mRNA deadenylase regulating posttranscriptional gene expression. However, regulation of CCR4 in virus infections is less understood.
Zhen-Jia Zhang, Qiang Gao, Xiao-Dong Fang, Zhi-Hang Ding, Dong-Min Gao, Wen-Ya Xu, Qing Cao, Ji-Hui Qiao, Yi-Zhou Yang, Chenggui Han, Ying Wang, Xuefeng Yuan, Dawei Li, Xian-Bing Wang   +13 more
doaj   +1 more source

The architecture of the Schizosaccharomyces pombe CCR4-NOT complex [PDF]

Nature Communications, 2016
AbstractCCR4-NOT is a large protein complex present both in cytoplasm and the nucleus of eukaryotic cells. Although it is involved in a variety of distinct processes related to expression of genetic information such as poly(A) tail shortening, transcription regulation, nuclear export and protein degradation, there is only fragmentary information ...
Marta Ukleja, Jorge Cuellar, Aleksandra Siwaszek, Joanna M. Kasprzak, Mariusz Czarnocki-Cieciura, Janusz M. Bujnicki, Andrzej Dziembowski, Jose M. Valpuesta   +7 more
openaire   +4 more sources

Ccr4-Not complex components genetically interact with and and play a role in transcription elongation

, 2011
Copyright information:Taken from "Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex"Nucleic Acids Research 2007;35(7):2428-2439.Published online 28 Mar 2007PMCID:PMC1874646.© 2007 The Author(s) () Tetrad ...
Akiko Inagaki (30053), H. Th. Marc Timmers (10936), Niels J. F. van den Broek (30054), Klaas W. Mulder (12134), Arjan B. Brenkman (30052)   +4 more
core   +1 more source

The enzymatic function of the CCR4 protein [PDF]

, 2001
The CCR4-NOT complex from Saccharomyces cerevisiae, which exists in two forms in vivo: 1.9 and 1.0 x 10 6 MDa in size, is a general transcriptional regulatory complex. It regulates mRNA transcription in initiation, elongation and degradation. The 1.0 MDa
Chen, Junji
core   +1 more source

Spotlight on Mogamulizumab-Kpkc for Use in Adults with Relapsed or Refractory Mycosis Fungoides or Sézary Syndrome: Efficacy, Safety, and Patient Selection

Drug Design, Development and Therapy, 2020
Amanda L Blackmon,1 Lauren Pinter-Brown1,2 1Division of Hematology/Oncology, Department of Medicine, University of California, Irvine, Irvine, CA, USA; 2Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA ...
Blackmon AL, Pinter-Brown L
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