Results 31 to 40 of about 34,716 (235)

Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways

Journal of Translational Medicine, 2023
Background Immunotargets including checkpoint inhibitors and toll-like receptor 8 agonists have recently gained attention for the recovery of hepatitis B virus (HBV)-specific T cell exhaustion in chronic hepatitis B(CHB).
Arshi Khanam, Alip Ghosh, Joel V. Chua, Shyam Kottilil   +3 more
doaj   +1 more source

Building on the Ccr4‐Not architecture

BioEssays, 2016
In a recent issue of Nature Communications Ukleja and co‐workers reported a cryo‐EM 3D reconstruction of the Ccr4‐Not complex from Schizosaccharomyces pombe with an immunolocalization of the different subunits. The newly gained architectural knowledge provides cues to apprehend the functional diversity of this major eukaryotic regulator. Indeed, in the
Villanyi, Zoltan, Collart, Martine
openaire   +4 more sources

Trametinib improves Treg selectivity of anti-CCR4 antibody by regulating CCR4 expression in CTLs in oral squamous cell carcinoma

Scientific Reports, 2022
Regulatory T-cells (Tregs) play a major role in suppressing anti-tumor immune responses. Mogamulizumab, an anti-CC chemokine receptor type 4 (CCR4) monoclonal antibody, depletes effector Tregs (eTregs). However, the clinical efficacy of mogamulizumab was
Shoya Ono, Susumu Suzuki, Yutaro Kondo, Ikuko Okubo, Mitsuo Goto, Tetsuya Ogawa, Hidefumi Kato, Hideaki Ito, Taishi Takahara, Akira Satou, Toyonori Tsuzuki, Kazuhiro Yoshikawa, Toru Nagao, Ryuzo Ueda   +13 more
doaj   +1 more source

Role of Ccr4-Not complex in heterochromatin formation at meiotic genes and subtelomeres in fission yeast. [PDF]

, 2015
BACKGROUND: Heterochromatin is essential for chromosome segregation, gene silencing and genome integrity. The fission yeast Schizosaccharomyces pombe contains heterochromatin at centromeres, subtelomeres, and mating type genes, as well as at small ...
Bähler, Jürg, Cotobal, Cristina, Duncan, Caia, Hasan, Ayesha, Mata, Juan, Rodríguez-López, María, Yamamoto, Masayuki, Yamashita, Akira   +7 more
core   +2 more sources

The Ccr4-Not complex interacts with the mRNA export machinery. [PDF]

PLoS ONE, 2011
The Ccr4-Not complex is a key eukaryotic regulator of gene transcription and cytoplasmic mRNA degradation. Whether this complex also affects aspects of post-transcriptional gene regulation, such as mRNA export, remains largely unexplored.
Shana C Kerr, Nowel Azzouz, Stephen M Fuchs, Martine A Collart, Brian D Strahl, Anita H Corbett, R Nicholas Laribee   +6 more
doaj   +1 more source

CCR8 leads to eosinophil migration and regulates neutrophil migration in murine allergic enteritis [PDF]

, 2019
Allergic enteritis (AE) is a gastrointestinal form of food allergy. This study aimed to elucidate cellular and molecular mechanisms of AE using a murine model. To induce AE, BALB/c wild type (WT) mice received intraperitoneal sensitization with ovalbumin
Blanco Pérez, Frank, Burggraf, Manja, Gonzalez Menendez, Irene, Iwakura, Yoichiro, Kato, Yoichiro, Kirberg, Jörg, Krause, Maren, Laiño, Jonathan Emiliano, Martella, Manuela, Ohbayashi, Masaharu, Quintanilla Martinez, Leticia, Scheurer, Stephan, Shibata, Noriyuki, Toda, Masako, Vieths, Stefan   +14 more
core   +1 more source

CCL17 and CCL22 chemokines are upregulated in human obesity and play a role in vascular dysfunction

Frontiers in Endocrinology, 2023
Background/AimsChemokines are known to play critical roles mediating inflammation in many pathophysiological processes. The aim of this study was to investigate the role of chemokine receptor CCR4 and its ligands CCL17 and CCL22 in human morbid obesity ...
Luisa Hueso, Patrice Marques, Brenda Morant, Herminia Gonzalez-Navarro, Herminia Gonzalez-Navarro, Herminia Gonzalez-Navarro, Joaquin Ortega, Joaquin Ortega, José T. Real, José T. Real, José T. Real, María J Sanz, María J Sanz, María J Sanz, Laura Piqueras, Laura Piqueras, Laura Piqueras   +16 more
doaj   +1 more source

Mathematical Model of HIV superinfection dynamics and R5 to X4 switch [PDF]

, 2006
During the HIV infection several quasispecies of the virus arise, which are able to use different coreceptors, in particular the CCR5 and CXCR4 coreceptors (R5 and X4 phenotypes, respectively).
Bagnoli, Franco, Lio, Pietro, Sguanci, Luca   +2 more
core   +1 more source

CHEMOKINE RECEPTORS AT DISTINCT DIFFERENTIATION STAGES OF T-HELPERS FROM PERIPHERAL BLOOD

Медицинская иммунология, 2016
Expression of chemokine receptors (CCR4, CCR6, CXCR3 and CXCR5) on T-helper (Th) cells at various levels of differentiation in a group of healthy volunteers (n = 52) was assessed on the basis of CD45RA and CD62L expression, using the eight-color flow ...
I. V. Kudryavtsev, A. G. Borisov, I. I. Krobinets, A. A. Savchenko, M. K. Serebriakova, Areg A. Totolian   +5 more
doaj   +1 more source

CCR4, a RNA decay factor, is hijacked by a plant cytorhabdovirus phosphoprotein to facilitate virus replication

eLife, 2020
Carbon catabolite repression 4 (CCR4) is a conserved mRNA deadenylase regulating posttranscriptional gene expression. However, regulation of CCR4 in virus infections is less understood.
Zhen-Jia Zhang, Qiang Gao, Xiao-Dong Fang, Zhi-Hang Ding, Dong-Min Gao, Wen-Ya Xu, Qing Cao, Ji-Hui Qiao, Yi-Zhou Yang, Chenggui Han, Ying Wang, Xuefeng Yuan, Dawei Li, Xian-Bing Wang   +13 more
doaj   +1 more source