Results 31 to 40 of about 21,976 (228)

Dose-dependent binding of anti-CCR4 IgG antibodies to CCR4⁺ and CCR4⁻ cell lines. [PDF]

, 2014
Different concentrations of 17G, 9E and KM3060var antibodies were tested in flow cytometry for binding to avian DT40 cells stably transfected with human CCR4 (a), to human HEK-293 cells transiently transfected with human CCR4 (b) or to human T-cell ...
Solène Géraudie (607007), Lavinia Gunnarsson (607006), Sergej M. Kiprijanov (607011), Urs B. Hagemann (607005), Herald Reiersen (6771), Remko A. Griep (607009), Ulrike Scheffler (607008), Alexander R. Duncan (607010)   +7 more
core   +1 more source

The architecture of the Schizosaccharomyces pombe CCR4-NOT complex [PDF]

Nature Communications, 2016
AbstractCCR4-NOT is a large protein complex present both in cytoplasm and the nucleus of eukaryotic cells. Although it is involved in a variety of distinct processes related to expression of genetic information such as poly(A) tail shortening, transcription regulation, nuclear export and protein degradation, there is only fragmentary information ...
Marta Ukleja, Jorge Cuellar, Aleksandra Siwaszek, Joanna M. Kasprzak, Mariusz Czarnocki-Cieciura, Janusz M. Bujnicki, Andrzej Dziembowski, Jose M. Valpuesta   +7 more
openaire   +4 more sources

The role of CCR4 and CRTH2 in asthma [PDF]

, 2007
There were no significant differences between healthy subjects and asthmatic patients in levels of expression of CCR4 and CRTH2 on CD4+ T cells and expression of activation/memory markers on either CD4+ or CCR4+/CD4+ T cells. Sections of bronchial biopsies from healthy or asthmatic subjects were found not to contain any CCR4 positive cells. Analysis of
Durkin, Kesta
openaire   +2 more sources

The structural basis for deadenylation by the CCR4-NOT complex [PDF]

Protein & Cell, 2010
The CCR4-NOT complex is a highly conserved, multifunctional machinery controlling mRNA metabolism. Its components have been implicated in several aspects of mRNA and protein expression, including transcription initiation, elongation, mRNA degradation, ubiquitination, and protein modification.
Mark, Bartlam, Tadashi, Yamamoto
openaire   +2 more sources

A CCR4 antagonist enhances DC activation and homing to the regional lymph node and shows potent vaccine adjuvant activity through the inhibition of regulatory T-cell recruitment

Journal of Pharmacological Sciences, 2018
CCR4 is a major chemokine receptor expressed by Treg cells that downregulate immune responses. Here, we investigated the role of CCR4-mediated Treg cell recruitment in antigen-specific immune responses.
Shinya Yamamoto, Kazuhiko Matsuo, Daisuke Nagakubo, Shintaro Higashiyama, Keiji Nishiwaki, Naoki Oiso, Akira Kawada, Osamu Yoshie, Takashi Nakayama   +8 more
doaj   +1 more source

The Ccr4-Not complex regulates TORC1 signaling and mitochondrial metabolism by promoting vacuole V-ATPase activity.

PLoS Genetics, 2020
The Ccr4-Not complex functions as an effector of multiple signaling pathways that control gene transcription and mRNA turnover. Consequently, Ccr4-Not contributes to a diverse array of processes, which includes a significant role in cell metabolism.
Hongfeng Chen, P Winston Miller, Daniel L Johnson, R Nicholas Laribee   +3 more
doaj   +1 more source

Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets [PDF]

, 2000
Platelets are known to contain platelet factor 4 and beta-thromboglobulin, alpha-chemokines containing the CXC motif, but recent studies extended the range to the beta-family characterized by the CC motif, including RANTES and Gro-alpha.
Christine A. Power, Marco Baggiolini, Kenneth J. Clemetson, Clemetson, JM, Baggiolini, M, Timothy N. C. Wells, Clemetson, KJ, Power, CA, Jeannine M. Clemetson, Amanda E. I. Proudfoot, Proudfoot, AE, Wells, TN   +11 more
core   +1 more source

Multifunctional roles of the mammalian CCR4-NOT complex in physiological phenomena

Frontiers in Genetics, 2014
The CCR4-NOT complex serves as one of the major deadenylases of eukaryotes. Although it was originally identified and characterized in yeast, recent studies have revealed that the CCR4-NOT complex also exerts important functions in mammals, including ...
Yo-Taro eShirai, Toru eSuzuki, Masahiro eMorita, Masahiro eMorita, Akinori eTakahashi, Tadashi eYamamoto   +5 more
doaj   +1 more source

Blockade of CCR4 breaks immune tolerance in chronic hepatitis B patients by modulating regulatory pathways

Journal of Translational Medicine, 2023
Background Immunotargets including checkpoint inhibitors and toll-like receptor 8 agonists have recently gained attention for the recovery of hepatitis B virus (HBV)-specific T cell exhaustion in chronic hepatitis B(CHB).
Arshi Khanam, Alip Ghosh, Joel V. Chua, Shyam Kottilil   +3 more
doaj   +1 more source

Different Regulations of ROM2 and LRG1 Expression by Ccr4, Pop2, and Dhh1 in the Saccharomyces cerevisiae Cell Wall Integrity Pathway

mSphere, 2016
Ccr4, a component of the Ccr4-Not cytoplasmic deadenylase complex, is known to be required for the cell wall integrity (CWI) pathway in the budding yeast Saccharomyces cerevisiae.
Xia Li, Tetsuro Ohmori, Kaoru Irie, Yuichi Kimura, Yasuyuki Suda, Tomoaki Mizuno, Kenji Irie   +6 more
doaj   +1 more source