Results 51 to 60 of about 21,976 (228)

CCR4-bearing T cells participate in autoimmune diabetes [PDF]

, 2002
Chemokine receptor expression is exquisitely regulated on T cell subsets during the course of their migration to inflammatory sites. In the present study we demonstrate that CCR4 expression marks a pathogenic population of autoimmune T cells.
Mary M. Cleary, David Chantry, Nora Sarvetnick, Sarvetnick, Nora, Howard S. Fox, Kim, Soon H., Fox, Howard S., ICOS Coporation, Soon H. Kim, Cleary, Mary M.   +9 more
core   +1 more source

CCR4+ Skin-Tropic Phenotype as a Feature of Central Memory CD8+ T Cells in Healthy Subjects and Psoriasis Patients

Frontiers in Immunology, 2020
The chemokine receptor CCR4 has emerged as a skin-homing molecule important for the migration of T cells from the blood to the dermis. From our previous data on psoriasis patients, CCR4+ memory T cells emerged as a putative recirculating population ...
Fabio Casciano, Marco Diani, Andrea Altomare, Francesca Granucci, Paola Secchiero, Giuseppe Banfi, Giuseppe Banfi, Eva Reali   +7 more
doaj   +1 more source

Architecture of the Ubiquitylation Module of the Yeast Ccr4-Not Complex [PDF]

Structure, 2015
The Ccr4-Not complex regulates eukaryotic gene expression at multiple levels, including mRNA turnover, translational repression, and transcription. We have studied the ubiquitylation module of the yeast Ccr4-Not complex and addressed how E3 ligase binds cognate E2 and how it is tethered to the complex.
Bhaskar V., Basquin J., Conti E.
openaire   +3 more sources

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

A degradatory fate for CCR4 suggests a primary role in Th2 inflammation [PDF]

, 2020
CCR4 is the sole receptor for the chemokines CCL22 and CCL17. Clinical studies of asthmatic airways have shown levels of both ligands and CCR4+ Th2 cells to be elevated, suggestive of a role in disease.
Solari, Roberto, Phillips, RM, Pease, James, Solari, R, Patel, Pallavi, Viney, JM, Pease, JE, Anderson, CA, Anderson, Caroline, Viney, Jonathan, Phillips, Rhian, Patel, P   +11 more
core   +1 more source

Twin Promotes the Maintenance and Differentiation of Germline Stem Cell Lineage through Modulation of Multiple Pathways

Cell Reports, 2015
The central question in stem cell regulation is how the balance between self-renewal and differentiation is controlled at the molecular level. This study uses germline stem cells (GSCs) in the Drosophila ovary to demonstrate that the Drosophila CCR4 ...
Ziwen Fu, Cuiyun Geng, Hui Wang, Zhihao Yang, Changjiang Weng, Hua Li, Lamei Deng, Luping Liu, Nan Liu, Jianquan Ni, Ting Xie   +10 more
doaj   +1 more source

Humanized anti CCR4 antibody KW0761 targets HTLV-1 infected CD4+ CCR4+ and CD8+CCR4+ T cells to treat HAM/TSP [PDF]

Retrovirology, 2015
Human T-lymphotropic virus type I (HTLV-1) can cause HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukemia/lymphoma (ATL). Since the prognosis for HAM/TSP patients is extremely poor, there is a strong demand for a novel therapeutic strategy, especially one which would effectively reduce HTLV-1 proviral load ...
Yamano, Yoshihisa, Yamauchi, Junji, Coler-Reilly, Ariella, Sato, Tomoo, Araya, Natsumi, Yagishita, Naoko, Kunitomo, Yasuo, Takahashi, Katsunori, Tanaka, Yuetsu, Akiyama, Hisanao, Hasegawa, Yasuhiro, Utsunomiya, Atae   +11 more
openaire   +1 more source

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source

CCR4^-/- mice show increased resistance to severe sepsis. [PDF]

, 2015
(A) WT (open symbols) and CCR4-/- (filled symbols) mice underwent sham (square) or L-CLP (circle) surgery. All groups received antibiotic therapy of ertapenem (75 mg/kg) at 6, 24 and 48 h after surgery. The survival of these mice was followed until day 7.
Cyntia Pecli (773548), José Carlos Alves-Filho (2155381), Fernando Q. Cunha (276880), Raphael Molinaro (773547), Steven L. Kunkel (197994), Claudio Canetti (642603), Claudia F. Benjamim (773550), Marcelo T. Bozza (343514), Rafael F. Guilherme (773549)   +8 more
core   +1 more source