Results 71 to 80 of about 21,976 (228)
Acta Medica Indonesiana, 2016 Aim: to determine the relationships between vitamin D and CCR4 expression on Treg, and Treg migratory capacity in SLE patients in Indonesia. Methods: vitamin D level assesment, CCR4 expression on Treg and Treg migratory capacity were performed on 41 SLE
Kusworini Handono +2 more
doaj +2 more sources
Cytometry Part B: Clinical Cytometry, EarlyView.Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley +1 more source
The enzymatic function of the CCR4 protein [PDF]
, 2001 The CCR4-NOT complex from Saccharomyces cerevisiae, which exists in two forms in vivo: 1.9 and 1.0 x 10 6 MDa in size, is a general transcriptional regulatory complex. It regulates mRNA transcription in initiation, elongation and degradation. The 1.0 MDa
Chen, Junji
core +1 more source
G3: Genes, Genomes, Genetics, 2018 The Ccr4 (carbon catabolite repression 4)-Not complex is a major regulator of stress responses that controls gene expression at multiple levels, from transcription to mRNA decay.
Jason E. Miller +5 more
doaj +1 more source
The control of elongation by the yeast Ccr4–Not complex [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013 The Ccr4-Not complex is a highly conserved nine-subunit protein complex that has been implicated in virtually all aspects of gene control, including transcription, mRNA decay and quality control, RNA export, translational repression and protein ubiquitylation.
openaire +2 more sources
Stable and Functional Regulatory T Cells for Adoptive Cell Therapy
Barrier Immunity, EarlyView.Deprivation of CD28 signaling combined with CDK8/19 inhibition induces stable iTregs with demethylation of Treg‐DRs. Re‐stimulation of these iTregs with additional agents further enhances their suppressive function. The generated S/F‐iTregs suppress inflammation in vivo, and subset of the suppressed Tconvs is converted into de novo pTregs, contributing
Norihisa Mikami
wiley +1 more source
Small-Molecule CCR4 Antagonists in Cutaneous T-cell Lymphoma [PDF]
Mycosis fungoides (MF) and Sézary syndrome (SS) are two most common types of cutaneous T-cell lymphoma (CTCL). Despite advances in understanding the pathogenesis of MF and SS, effective treatments remain limited.
Han, Wei +5 more
core +1 more source
Psoriatic inflammation enhanced CCR4 and CKLF1 expression by HUVECs. [PDF]
, 2015 (a) Primary HUVECs exhibited strong factor VIII staining (green) by immunofluorescence. Nuclei were stained by 4',6-diamidino-2-phenylindole (blue). (b) qRT-PCR confirmed elevation of mRNA levels of both CCR4 and CKLF1 upon the addition of psoriatic sera.
Yaqi Tan (730337) +5 more
core +1 more source
Precision Radiation Oncology, EarlyView.The dual immunomodulatory network of radiotherapy in hepatocellular carcinoma. Radiotherapy initiates its effects by inducing immunogenic cell death and DNA double‐strand breaks. Immune Activation: Cytosolic DNA from damaged cells activates the cGAS‐STING pathway, triggering IRF3/NF‐κB‐mediated type I interferon production. This enhances dendritic cell
Zhigang Fu +4 more
wiley +1 more source
Etude structurale du complexe CCR4-NOT [PDF]
, 2015 MRNA turnover begins with deadenylation where in the poly(A) tail at the 3’ end of the mRNA is removed. Deadenylation is the rate-limiting step of the decay pathway.
Basquin, Jérôme
core