Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex
Frontiers in Genetics, 2013 The shortening of the poly(A) tail of cytoplasmic mRNA (deadenylation) is a pivotal step in the regulation of gene expression in eukaryotic cells. Deadenylation impacts on both regulated mRNA decay as well as the rate of mRNA translation.
Gerlof Sebastiaan Winkler +1 more
doaj +1 more source
The Not4 E3 ligase and CCR4 deadenylase play distinct roles in protein quality control. [PDF]
PLoS ONE, 2014 Eukaryotic cells control their proteome by regulating protein production and protein clearance. Protein production is determined to a large extent by mRNA levels, whereas protein degradation depends mostly upon the proteasome.
David Halter +2 more
doaj +1 more source
Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions
Allergy, EarlyView.Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira +13 more
wiley +1 more source
The role of CD8+CCR4+ T-cells in axial spondyloarthritis [PDF]
, 2019 Axial spondyloarthritis (AxSpA) is an inflammatory disease affecting the axial skeleton. The infiltrate of T-cells in the structural lesions has been found to contribute to bone remodeling, but consensus relating the functional contribution of different
Silvestri, Ylenia <1990>
core +1 more source
The cellular roles of Ccr4-NOT in model and pathogenic fungi – implications for fungal virulence
Frontiers in Genetics, 2013 The fungal Ccr4-NOT complex has been implicated in orchestrating gene expression networks that impact on pathways key for virulence in pathogenic species.
John C. Panepinto +2 more
doaj +1 more source
CCR4 Controls the Suppressive Effects of Regulatory T Cells on Early and Late Events during Severe Sepsis. [PDF]
PLoS ONE, 2015 Sepsis is a deadly disease characterized by an overwhelming release of inflammatory mediators and the activation of different types of cells. This altered state of cell activation, termed leukocyte reprogramming, contributes to patient outcome.
Raphael Molinaro +8 more
doaj +1 more source
Allergy, EarlyView.Obesity altered the inflammatory phenotype of HDM‐induced allergic airway inflammation in C57BL/6 mice, indicated by changed BAL cell composition. Single‐cell CITE‐Seq identified the lack of a CD4+ T‐cell subcluster characterized by co‐inhibitory receptor expression in obese HDM‐exposed C57BL/6 mice.
Sarah Miethe +12 more
wiley +1 more source
Functional Analysis of CCR4-NOT Complex in Pancreatic β Cell [PDF]
, 2020 Okinawa Institute of Science and Technology Graduate UniversityDoctor of PhilosophyFunctional analysis of CCR4-NOT complex in pancreatic β cell Pancreatic β cells are responsible for production and secretion of insulin in response to increasing blood ...
Mostafa, Dina
core +1 more source
E2F2 stimulates CCR4 expression and activates synovial fibroblast-like cells in rheumatoid arthritis
Central European Journal of Immunology, 2021 Wanju Xu, Shufeng Li, Xiaotian Chang
doaj +1 more source
Spatial Transcriptomics Identifies Characteristic Immunological Niches in Atopic Dermatitis
Allergy, EarlyView.Spatially organized immune niches containing mature migratory dendritic cells (mmDCs) and CD4+ T cells in atopic dermatitis lesions support localized T cell activation and may contribute to disease persistence. Spatial transcriptomics identifies conserved immune niches in atopic dermatitis lesions, characterized by close co‐localization of CD4+ T cells
Lina Gross +11 more
wiley +1 more source