Results 81 to 90 of about 23,452 (228)
The control of elongation by the yeast Ccr4–Not complex [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013 The Ccr4-Not complex is a highly conserved nine-subunit protein complex that has been implicated in virtually all aspects of gene control, including transcription, mRNA decay and quality control, RNA export, translational repression and protein ubiquitylation.
openaire +2 more sources
Increased CCR4 Expression in Cutaneous T Cell Lymphoma [PDF]
, 2002 Chemokines are critical molecules in leukocyte trafficking, promoting site-specific migration to various tissues. The chemokine receptor CCR4 has recently been associated with skin-homing T cells.
Kupper, Thomas S. +4 more
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Andrology, EarlyView.ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam +7 more
wiley +1 more source
The multifunctional Ccr4–Not complex directly promotes transcription elongation
, 2011 The Ccr4–Not complex has been implicated in the control of multiple steps of mRNA metabolism; however, its functions in transcription remain ambiguous.
Arnob Dutta +4 more
core +1 more source
scRNA‐Seq in Gastric Cancer Reveals Macrophage‐Derived C1q as a Diagnostic Marker
Cancer Science, EarlyView.Single‐cell sequencing of GC analyzed the tumor microenvironment and discovered the C1QA+ TAMs subpopulation with immunosuppressive function. The role of C1q in the prognosis and diagnosis of GC was demonstrated through plasma and tumor tissue from the GC cohort.
Saisai Gong +6 more
wiley +1 more source
Journal of Cutaneous Pathology, EarlyView.ABSTRACT Primary cutaneous gamma‐delta T‐cell lymphoma (PCGD‐TCL) is a rare cytotoxic lymphoma with key oncogenic drivers in the JAK/STAT pathway. Also primarily involving the subcutaneous adipose tissue, subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL) is more frequently encountered in scenarios of autoimmune disorders.
Bennett Christie‐Nguyen +6 more
wiley +1 more source
Role of Cemokine Receptor 4 (CCR4) in Cardiac Allograft Rejection [PDF]
, 2005 Die akute Abstoßung und das chronische Transplantatversagen sind nach wie vor zentrale Probleme in der Transplantationsmedizin. Chemokine nehmen hierbei über die Rekrutierung von Effektorzellen entscheidenden Einfluss auf die ablaufenden immunologischen ...
Hüser, Norbert
core
CCR4-/- mice show increased resistance to severe sepsis.
, 2015 (A) WT (open symbols) and CCR4-/- (filled symbols) mice underwent sham (square) or L-CLP (circle) surgery. All groups received antibiotic therapy of ertapenem (75 mg/kg) at 6, 24 and 48 h after surgery. The survival of these mice was followed until day 7.
Cyntia Pecli (773548) +8 more
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Isolation and characterization of the CCR4 associated factors [PDF]
, 1995 In yeast, Sacchoromyces cerevisiae, transcription of $\underline{ADH2}$ gene (encodes alcohol dehydrogenase II) under glucose derepression conditions requires not only the gene-specific activator, Adr1p, but also the general transcriptional factors like ...
Liu, Haiyan
core +1 more source
Cutaneous lymphomas – an update
Histopathology, EarlyView.Primary cutaneous lymphomas and lymphoproliferative disorders are defined by integrated clinical, histopathological, immunophenotypic and genetic features as diagnostic criteria also in the 5th edition of the WHO classification of haematolymphoid tumors.
Werner Kempf, Christina Mitteldorf
wiley +1 more source