Results 91 to 100 of about 23,452 (228)

Ccr4–Not is at the core of the eukaryotic gene expression circuitry

Biochemical Society Transactions, 2015
In this mini-review, we summarize our current knowledge about the cross-talk between the different levels of gene expression. We introduce the Ccr4 (carbon catabolite repressed 4)–Not (negative on TATA-less) complex as a candidate to be a master regulator that orchestrates between the different levels of gene expression.
Villanyi Zoltan, Collart Martine A.
openaire   +6 more sources

Characterisation of antagonist binding sites on chemokine receptor CCR4 [PDF]

, 2013
CCR4 is a chemokine receptor notably expressed on T helper 2 and regulatory T cells. CCR4 binds the chemokines CCL17 and CCL22. These are involved in T cell homeostasis and inflammatory diseases including asthma and atopic dermatitis, making CCR4 a ...
Viney, Jonathan Mark
core   +1 more source

Design, Synthesis and SAR Study of Novel Trisubstituted Pyrimidine Amide Derivatives as CCR4 Antagonists

Molecules, 2014
The design, synthesis and structure-activity relationship studies of some novel trisubstituted pyrimidine amide derivatives prepared as CCR4 antagonists are described. The activities of these compounds were evaluated by the CCR4-MDC chemotaxis inhibition
Libao Xu, Yang Zhang, Wenjie Dai, Ying Wang, Dan Jiang, Lili Wang, Junhai Xiao, Xiaohong Yang, Song Li   +8 more
doaj   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Role of Th17 cell expansion through CCR4 in psoriasis [PDF]

本研究は、乾癬におけるケモカイン受容体CCR4の役割の解明を目的とする。CCR4欠損マウスは、皮膚の肥厚や紅斑、鱗屑といった乾癬様病態の軽減および乾癬関連遺伝子の発現減少を示した。この時、病変皮膚および所属リンパ節において、Th17細胞が減少していた。さらに、所属リンパ節において、CCR4陽性のTh17細胞とCCL22産生の樹状細胞がクラスターを形成しており、CCR4欠損マウスでは、それが減少していた。また、選択的CCR4阻害薬でも同様の結果が得られた。以上より、CCR4は ...
中山, 隆志, Nakayama, Takashi, 60319663   +2 more
core   +1 more source

Role of Cnot6l in maternal mRNA turnover

Life Science Alliance, 2018
Mice lacking Cnot6l , a deadenylase component of the CCR4–NOT complex, are viable, but females have ∼40% smaller litters. Cnot6l is a maternal-effect gene acting in maternal mRNA degradation.
Filip Horvat, Helena Fulka, Radek Jankele, Radek Malik, Ma Jun, Katerina Solcova, Radislav Sedlacek, Kristian Vlahovicek, Richard M Schultz, Petr Svoboda   +9 more
doaj   +1 more source

The Role of Innate Lymphoid Cells in Autoimmune, Allergic and Infectious Diseases: A Systematic Review

Immunology, EarlyView.
This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann, Henrique R. Dal‐Pizzol, Louise M. Lückmann, Davi E. Salini, Bruna C. Hasckel, Mikaeli Minati, Bruno Kluwe‐Schiavon, Tatiana Barichello   +7 more
wiley   +1 more source

Novel roles of the multifunctional CCR4-NOT complex in post-transcriptional regulation

Frontiers in Genetics, 2014
The CCR4-NOT complex is highly conserved gene silencer, and more general functions of the complex have been elucidated at post-transcriptional levels. Specific regulatory proteins, including miRNA-induced silencing complex and its associate protein, bind
Toshifumi eInada, Shiho eMakino
doaj   +1 more source

Initial OX40–OX40L Signaling Promotes a Skin‐Resident Memory T‐Cell Reservoir in Atopic Dermatitis

Allergy, EarlyView.
Takayoshi Komatsu‐Fujii, Ryota Asahina, Tatsuya Hasegawa, Satoshi Nakamizo, Saeko Nakajima, Toshiaki Kogame, Kenji Kabashima   +6 more
wiley   +1 more source

Immune‐related adverse events with mogamulizumab in cutaneous T‐cell lymphoma: A multicentre study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
In a nationwide multicentre study of 403 patients with cutaneous T‐cell lymphoma treated with mogamulizumab, non‐MAR immune‐related adverse events were reported in 8.4% of patients across responding centres. These events were diverse, sometimes severe or persistent, and could occur late during mogamulizumab treatment.
David Neubauer, Pascale Palassin, Caroline Ram‐Wolff, Adèle De Masson, Jeremie Delaleu, Diane Kottler, Florent Amatore, Henri Adamski, Claudia Bejar, Raphaël Janela‐Lapert, Emmanuella Guenova, Pauline Bernard, Coralie Lheure, Laurent Machet, Laura Troin, Gaëlle Quereux, Anne Pham‐Ledard, Sarah Faiz, Florent Grange, Yannick Le Corre, Arjen Nikkels, Stéphane Barete, Lorena Manea, Emmanuelle Amazan, Alexandre Tj Maria, Lionel Moulis, Olivier Dereure, Quentin Samaran, For the Groupe Français d'Étude des Lymphomes Cutanés (GFELC)   +28 more
wiley   +1 more source