Results 101 to 110 of about 34,716 (235)

The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb. [PDF]

, 2019
Overexpression of the oncogene MYBL2 (B-Myb) is associated with increased cell proliferation and serves as a marker of poor prognosis in cancer. However, the mechanism by which B-Myb alters the cell cycle is not fully understood.
Ananthapadmanabhan, Varsha, Dozmorov, Mikhail, Felthousen, Jessica, Guiley, Keelan Z, Iness, Audra N, Litovchick, Larisa, Rubin, Seth M, Saini, Siddharth, Sesay, Fatmata   +8 more
core  

Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs, Eslam A. Elghonaimy, Praveen Ramakrishnan Geethakumari, Kiran A. Kumar, Joseph F. Merola, Heather W. Goff, Todd A. Aguilera   +6 more
wiley   +1 more source

An mRNA decapping mutant deficient in P body assembly limits mRNA stabilization in response to osmotic stress [PDF]

, 2017
Yeast is exposed to changing environmental conditions and must adapt its genetic program to provide a homeostatic intracellular environment. An important stress for yeast in the wild is high osmolarity.
A Totaro, A van Hoof, AD Aragon, AP Gasch, AR Albig, C Janke, C Miller, C Molin, CJ Decker, CJ Decker, CW Bourque, D Cao, D Melamed, D Teixeira, D Teixeira, D Zheng, E Garre, F Posas, G Gowrishankar, G Haas, G Haimovich, GR Pilkington, H Donis-Keller, J Coller, J Schindelin, J Warringer, J Yale, JA Arribere, JF Garcia, JF Garcia, JR Buchan, JR Buchan, JS Anderson, JS Bett, L Hatfield, L Romero-Santacreu, M Brengues, M Kshirsagar, M Rep, M Tucker, MAM Reijns, N Alhusaini, N Cougot, N Otsu, R Parker, S Hohmann, S Huch, S Jain, S Tharun, T Grousl, T Nissan, U Sheth, U Sheth, V Balagopal, V Hilgers, V Pelechano, V Pelechano, W Hu, Y Uesono   +58 more
core   +1 more source

OsFKBP20‐1b stabilizes OsUPF1 and OsUPF2 to promote the degradation of aberrant mRNAs during dehydration stress

Journal of Integrative Plant Biology, EarlyView.
The rice protein OsFKBP20‐1b protects key RNA‐surveillance factors from breakdown, so they can better eliminate defective messages. This RNA quality‐control boost reduces errors and helps plants survive drought, revealing a link between RNA control and drought tolerance.
Haemyeong Jung, Hyun Ji Park, Seung Hee Jo, Ki‐Hong Jung, Choonkyun Jung, Hye Sun Cho   +5 more
wiley   +1 more source

CCR4 is a determinant of melanoma brain metastasis

Oncotarget, 2017
We previously identified the chemokine receptor CCR4 as part of the molecular signature of melanoma brain metastasis. The aim of this study was to determine the functional significance of CCR4 in melanoma brain metastasis. We show that CCR4 is more highly expressed by brain metastasizing melanoma cells than by local cutaneous cells from the same ...
Klein, Anat, Sagi-Assif, Orit, Meshel, Tsipi, Telerman, Alona, Izraely, Sivan, Ben-Menachem, Shlomit, Bayry, Jagadeesh, Marzese, Diego, Ohe, Shuichi, Hoon, Dave S.B., Erez, Neta, Witz, Isaac   +11 more
openaire   +4 more sources

Role of Cnot6l in maternal mRNA turnover

Life Science Alliance, 2018
Mice lacking Cnot6l , a deadenylase component of the CCR4–NOT complex, are viable, but females have ∼40% smaller litters. Cnot6l is a maternal-effect gene acting in maternal mRNA degradation.
Filip Horvat, Helena Fulka, Radek Jankele, Radek Malik, Ma Jun, Katerina Solcova, Radislav Sedlacek, Kristian Vlahovicek, Richard M Schultz, Petr Svoboda   +9 more
doaj   +1 more source

Circular RNAs in Lotus japonicus Responses to Nutrient Supply and Mesorhizobium Symbiosis

Plant, Cell &Environment, EarlyView.
ABSTRACT Symbiotic interactions between legumes and rhizobia enable nitrogen fixation under low nutrient conditions. The establishment and function of symbiotic interactions require coordinated changes in gene expression in both the host and the microbe. Circular RNAs (circRNAs) are endogenous gene‐specific molecules that can regulate transcription and
Delecia Utley, Asa Budnick, Simona Radutoiu, Heike Sederoff   +3 more
wiley   +1 more source

CCR4, HTLV-1 infection, and ATL oncogenesis

Uirusu, 2008
Adult T-cell leukemia (ATL) is a malignancy of mature CD4+ T cells that is etiologically associated with the infection of human T-cell leukemia virus type 1 (HTLV-1), an exogenous human retrovirus. Previously, we have shown that leukemic cells of most ATL patients express CCR4, a chemokine receptor known to be selectively expressed by T cell subsets ...
openaire   +3 more sources

Novel roles of the multifunctional CCR4-NOT complex in post-transcriptional regulation

Frontiers in Genetics, 2014
The CCR4-NOT complex is highly conserved gene silencer, and more general functions of the complex have been elucidated at post-transcriptional levels. Specific regulatory proteins, including miRNA-induced silencing complex and its associate protein, bind
Toshifumi eInada, Shiho eMakino
doaj   +1 more source

Differential requirement for P2X7R function in IL-17 dependent vs. IL-17 independent cellular immune responses [PDF]

, 2014
IL17-dependent autoimmunity to collagen type V (Col V) has been associated with lung transplant obliterative bronchiolitis. Unlike the T helper 1 (Th1)-dependent immune responses to Tetanus Toxoid (TT), the Th17 response to Col V in lung transplant ...
Burlingham, W. J., Denlinger, L. C., Greenspan, D. S., Hegde, S., Jankowska-Gan, E., Roenneburg, D., Shi, L., Sullivan, J. A., Wilkes, D. S.   +8 more
core   +1 more source