Results 121 to 130 of about 21,976 (228)
Protein Science, Volume 35, Issue 7, July 2026.Abstract Mitochondria import the majority of their proteins from the cytosol, creating a fundamental challenge: precursor proteins must be synthesized, maintained in an import‐competent state, and delivered to mitochondrial translocases without premature folding or aggregation. While mitochondrial protein import has been considered a post‐translational
Nikita A. Kvasov, Yury S. Bykov
wiley +1 more source
Cellular Heterogeneity During Arterial Aging
Aging Cell, Volume 25, Issue 7, July 2026.Graphical abstract showing arterial cell subpopulations and their functional changes during aging. Transcriptomic profiling studies across species identify age‐associated endothelial, smooth muscle, fibroblast, and immune cell states characterized by inflammation, extracellular matrix remodeling, phenotypic switching, and cellular senescence ...
He Xu +3 more
wiley +1 more source
Role of Th17 cell expansion through CCR4 in psoriasis [PDF]
本研究は、乾癬におけるケモカイン受容体CCR4の役割の解明を目的とする。CCR4欠損マウスは、皮膚の肥厚や紅斑、鱗屑といった乾癬様病態の軽減および乾癬関連遺伝子の発現減少を示した。この時、病変皮膚および所属リンパ節において、Th17細胞が減少していた。さらに、所属リンパ節において、CCR4陽性のTh17細胞とCCL22産生の樹状細胞がクラスターを形成しており、CCR4欠損マウスでは、それが減少していた。また、選択的CCR4阻害薬でも同様の結果が得られた。以上より、CCR4は ...
中山, 隆志 +2 more
core
Mogamulizumab Treatment in a Hemodialysis Patient with Adult T-Cell Leukemia/Lymphoma
Turkish Journal of Hematology, 2014 Mari Yoshihara +5 more
doaj +1 more source
Allergy, Volume 81, Issue 7, Page 2309-2324, July 2026.ABSTRACT Atopic dermatitis and psoriasis are two common cutaneous chronic inflammatory diseases. Although they share similar immunological mechanisms, their clinical implications in the patient are different. This review compares both diseases from different points of view such as genetics, natural history, triggers of disease, and skin barrier defects
Tali Czarnowicki +6 more
wiley +1 more source
British Journal of Haematology, Volume 209, Issue 1, Page 42-53, July 2026.Summary Sézary syndrome (SS) is an aggressive cutaneous T‐cell lymphoma, characterized by erythroderma, lymphadenopathy and circulating malignant CD4+ T cells. Despite therapeutic advances, SS remains an incurable disease. Early diagnosis is therefore essential for timely therapeutic intervention; however, reliable biomarkers to identify circulating SS
Sara Marchisio +14 more
wiley +1 more source
QSAR STUDY OF TRISUBSTITUTED THIAZOLIDINONES AS CCR4 ANTAGONISTS [PDF]
, 2009 CCR4 is selectively expressed on Th2-type CD4+ T-cells, which play a pivotal role in driving the allergic inflammation response . CCR4 antagonists are used for the treatment of allergic inflammation .Substituted thiazolidinones were identified as CCR4 ...
V Shanthi +2 more
core
Allergy, Volume 81, Issue 7, Page 2523-2526, July 2026.
Nami Shrestha Palikhe +7 more
wiley +1 more source
Polymorphism in CCR4 Gene (1014 C/T) in Patients with Breast Carcinoma from the South of Iran
Armaghane Danesh Bimonthly Journal, 2013 Background & aim: CCR4 gene polymorphism at position C/T1014 has been associated with changes in mRNA stability and is involved expression of this molecule.
F Moghaddasi, MR Haghshenas, S Naeimi
doaj
Case Reports in OncologyIntroduction: CC chemokine receptor 4 (CCR4), which is involved in leukocyte migration, is expressed in most tumor cells in patients with adult T-cell leukemia/lymphoma (ATLL).
Masatomo Shimizu +5 more
doaj +1 more source