Results 121 to 130 of about 23,452 (228)
Evasins: Biology and Therapeutic Potential of Broad‐Spectrum Chemokine Inhibitors
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.ABSTRACT Ticks are haematophagous parasites that rely on uninterrupted bloodmeals for survival and need an effective strategy to suppress the host inflammatory response. Leukocyte recruitment is a chemokine‐mediated hallmark of inflammation, which ticks counteract via anti‐chemokine proteins in their saliva named evasins.
Emilia L. Bialek +3 more
wiley +1 more source
C‐C Chemokine Receptor 4 Deficiency Protects Against Abdominal Aortic Aneurysm Formation
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground The dysregulated immune system, which drives chronic vascular inflammation and remodeling, plays a critical role in the pathogenesis of abdominal aortic aneurysm (AAA).
Aga Krisnanda +14 more
doaj +1 more source
Selective Depletion of Tumor‐Infiltrating CD4+CCR8+ Tregs by AZ084, a Novel CCR8 Antagonist
Cancer Science, Volume 117, Issue 10, Page 2719-2732, October 2026.AZ084, a novel CCR8 antagonist, selectively targets tumor‐infiltrating CD4+CCR8+ Tregs, reduces their immunosuppressive function, and decreases IL‐10/TGF‐β production. ABSTRACT Regulatory T cells (Tregs) are key mediators of immunosuppression in ovarian cancer, yet strategies for selectively targeting tumor‐infiltrating Tregs remain limited.
Yepeng Mao +12 more
wiley +1 more source
Experimental Physiology, Volume 111, Issue 10, Page 4507-4524, 1 October 2026.Abstract Sjögren's disease is an autoimmune disease characterized by severe dry eye, but its pathophysiology remains unclear. Non‐obese diabetic (NOD) mice develop Sjögren's disease‐like dry eye prior to the onset of diabetes. Although intestinal immune abnormalities precede diabetes in NOD mice, their relationship to dry eye remains poorly understood.
Kenji Goto +3 more
wiley +1 more source
The evolving role of immunotherapy in ovarian cancer
Cancer, Volume 132, Issue 18, 15 September 2026.Abstract Ovarian cancer remains a major cause of gynecologic cancer mortality; and, although immune checkpoint inhibitors have transformed treatment in other solid tumors, their activity in ovarian cancer has been limited by tumor heterogeneity, an immunosuppressive tumor microenvironment, and the lack of robust predictive biomarkers.
Ana Carolina Veneziani +2 more
wiley +1 more source
Polymorphism in CCR4 Gene (1014 C/T) in Patients with Breast Carcinoma from the South of Iran
Armaghane Danesh Bimonthly Journal, 2013 Background & aim: CCR4 gene polymorphism at position C/T1014 has been associated with changes in mRNA stability and is involved expression of this molecule.
F Moghaddasi, MR Haghshenas, S Naeimi
doaj
Th2型趋化因子受体CCR4在原位肝移植急性排斥反应中的表达
Zhongguo shiyan zhenduanxue, 2005 目的 通过检测Th2型趋化因子受体CCR4在移植肝脏急性排斥反应中的表达,探讨Th2型细胞在肝移植急性排斥反应中的作用机制。方法 根据Banff病理分级将原位肝移植术后肝穿刺活检标本分成4组,应用RT -PCR方法半定量分析各组标本中CCR4的mRNA水平。结果 轻度排斥组中11例CCR4高水平表达;中度排斥组中6例、未排斥组中5例CCR4中度水平表达;正常对照组、重度排斥组CCR4均轻度表达。结论 肝移植免疫微环境中CCR4的表达可能与免疫耐受的诱导有关;Th1 ...
孟醒初, 张家颖, 朱志军, 宋燕
doaj
Case Reports in OncologyIntroduction: CC chemokine receptor 4 (CCR4), which is involved in leukocyte migration, is expressed in most tumor cells in patients with adult T-cell leukemia/lymphoma (ATLL).
Masatomo Shimizu +5 more
doaj +1 more source
QSAR STUDY OF TRISUBSTITUTED THIAZOLIDINONES AS CCR4 ANTAGONISTS [PDF]
, 2009 CCR4 is selectively expressed on Th2-type CD4+ T-cells, which play a pivotal role in driving the allergic inflammation response . CCR4 antagonists are used for the treatment of allergic inflammation .Substituted thiazolidinones were identified as CCR4 ...
V Shanthi +2 more
core
Nature CommunicationsTristetraprolin family of proteins regulate mRNA stability by binding to specific AU-rich elements in transcripts. This binding promotes the shortening of the mRNA poly(A) tail, or deadenylation, initiating mRNA degradation.
Filip Pekovic +6 more
doaj +1 more source