Results 41 to 50 of about 22,512 (231)
Silencing of CCR4-NOT complex subunits affects heart structure and function [PDF]
Disease Models & Mechanisms, 2020 ABSTRACT The identification of genetic variants that predispose individuals to cardiovascular disease and a better understanding of their targets would be highly advantageous. Genome-wide association studies have identified variants that associate with QT-interval length (a measure of myocardial repolarization).
Lisa Elmén +13 more
openaire +3 more sources
The cellular roles of Ccr4-NOT in model and pathogenic fungi – implications for fungal virulence
Frontiers in Genetics, 2013 The fungal Ccr4-NOT complex has been implicated in orchestrating gene expression networks that impact on pathways key for virulence in pathogenic species.
John C. Panepinto +2 more
doaj +1 more source
Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4–NOT
Nature Structural & Molecular Biology, 2023 Translation affects messenger RNA stability and, in yeast, this is mediated by the Ccr4-Not deadenylation complex. The details of this process in mammals remain unclear. Here, we use cryogenic electron microscopy (cryo-EM) and crosslinking mass spectrometry to show that mammalian CCR4-NOT specifically recognizes ribosomes that are stalled during ...
Eva Absmeier +5 more
openaire +2 more sources
Ccr4‐Not complex directly regulates transcription elongation
The FASEB Journal, 2010 Many functions have been ascribed to the Ccr4‐Not complex. First described many years ago as a potential regulator of preinitiation complex (PIC) formation, more recently, a large body of evidence indicates it is predominantly cytoplasmic and regulates deadenylation of mRNA and ubiquitylation of substrates in ...
Joseph C Reese +3 more
openaire +1 more source
The structural basis for deadenylation by the CCR4-NOT complex [PDF]
Protein & Cell, 2010 The CCR4-NOT complex is a highly conserved, multifunctional machinery controlling mRNA metabolism. Its components have been implicated in several aspects of mRNA and protein expression, including transcription initiation, elongation, mRNA degradation, ubiquitination, and protein modification.
Mark, Bartlam, Tadashi, Yamamoto
openaire +2 more sources
Insights into the structure and architecture of the CCR4-NOT complex
Frontiers in Genetics, 2014 The CCR4-NOT complex is a highly conserved, multifunctional machinery with a general role in controlling mRNA metabolism. It has been implicated in a number of different aspects of mRNA and protein expression, including mRNA degradation, transcription ...
Kun eXu +4 more
doaj +1 more source
The 5' → 3' exoribonuclease XRN1/Pacman and its functions in cellular processes and development [PDF]
, 2012 XRN1 is a 5' → 3' processive exoribonuclease that degrades mRNAs after they have been decapped. It is highly conserved in all eukaryotes, including homologs in Drosophila melanogaster (Pacman), Caenorhabditis elegans (XRN1), and Saccharomyces cerevisiae (
Jones, Christopher Iain +2 more
core +1 more source
G3: Genes, Genomes, Genetics, 2018 The Ccr4 (carbon catabolite repression 4)-Not complex is a major regulator of stress responses that controls gene expression at multiple levels, from transcription to mRNA decay.
Jason E. Miller +5 more
doaj +1 more source
Translational control of ERK signaling through miRNA/4EHP-directed silencing
eLife, 2018 MicroRNAs (miRNAs) exert a broad influence over gene expression by directing effector activities that impinge on translation and stability of mRNAs.
Seyed Mehdi Jafarnejad +18 more
doaj +1 more source
Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype. [PDF]
, 2017 Cancer cells exhibit dramatic alterations of chromatin organization at cis-regulatory elements, but the molecular basis, extent, and impact of these alterations are still being unraveled.
Burgos, E +11 more
core +1 more source