Results 51 to 60 of about 2,257 (136)
Arthritis &Rheumatology, EarlyView.Objective We aimed to characterize CD4+ T cell plasticity in human systemic lupus erythematosus (SLE) by leveraging T cell receptor (TCR) repertoire features as markers of prior lineage states, integrating TCR and transcriptomic profiling to delineate plasticity patterns and evaluate their association with clinical disease activity. Methods We used TCR
Yasuo Nagafuchi +11 more
wiley +1 more source
Functional characterization of the CCR4-NOT transcriptional regulatory complex [PDF]
, 1999 The CCR4-NOT transcriptional regulatory complex affects expression of a number of genes both positively and negatively. This study demonstrates that the CCR4-NOT complex functionally and physically interacts with TBP and TAFs. Firstly, mutations in CCR4,
Badarinarayana, Vasudeo
core +1 more source
T cells, the Next Big Target in Axial Spondyloarthritis?
Arthritis &Rheumatology, EarlyView.Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley +1 more source
Composition and function of Ccr4-Not protein complexes [PDF]
, 2010 Ccr4-Not protein complexes are evolutionarily conserved and have important functions in mRNA regulatory processes. Strict regulation of mRNA’s is important for cells since they form the central connection between the genetic information in the nucleus ...
Lau, N.C.
core +1 more source
Cells, 2023 The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression.
Nafiseh Chalabi Hagkarim +6 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective CD4 T cells specific for citrullinated (cit) peptides are key players in rheumatoid arthritis (RA) immunopathogenesis. Characterizing these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next ...
James A. Stanway +13 more
wiley +1 more source
, 1999 The CCR4-NOT complex (1 mDa in size), consisting of the proteins CCR4, CAF1, and NOT1 to NOT5, regulates gene expression both positively and negatively and is distinct from other large transcriptional complexes in Saccharomyces cerevisiae such as SNF/SWI,
Chiang, Yueh-Chin +5 more
core +1 more source
Cytometry Part B: Clinical Cytometry, EarlyView.Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley +1 more source
CCL17‐CCR4 axis contributes to the onset of vitiligo in mice
Immunity, Inflammation and Disease, 2021 Background Destruction of melanocytes mediated by autoimmunity is currently believed as the main cause of vitiligo. This article aims to identify the role of CC chemokine ligand 17 (CCL17)–CC chemokine receptor 4 (CCR4) axis in vitiligo and provide new ...
He Li +4 more
doaj +1 more source
Exploration, EarlyView.The deficiency of PNLDC1 exacerbates the advancement of CRC. PNLDC1 interacts with TUBB4B mRNA to regulate the p53–p21–CDK2–cyclin E2 pathway, thereby influencing the G2/M phase of the cell cycle. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, highlighting the urgent need for novel therapeutic strategies.
Lexin Liu +18 more
wiley +1 more source