Results 61 to 70 of about 2,257 (136)

Autosomal Dominant Hyper‐IgE Syndrome Patients Retain IL10‐Producing preTh17‐Cells That Are Activated by Opportunistic Pathogens and Support IgE Production

Allergy, EarlyView.
IL‐10 producing CCR6+Th‐cells are central memory T‐cells that express ROR‐γt and differentiate to Th17‐cells via an autocrine loop of STAT3‐activating cytokines (preTh17). STAT3‐deficient AD‐HIES patients lack Th17‐ and Tfh17‐cells but retain preTh17‐ and Th1/17‐cells.
Giorgia Moschetti, Chiara Vasco, Francesca Clemente, Paola Larghi, Sara Maioli, Edoardo Scarpa, Elena Carelli, Nadia Pulvirenti, Maria Lucia Sarnicola, Mariacristina Crosti, Manal Bel Imam, Willem van de Veen, Loris Rizzello, Sergio Abrignani, Lucia A. Baselli, Rosa Maria Dellepiane, Maria Carrabba, Giovanna Fabio, Jens Geginat   +18 more
wiley   +1 more source

CHEMOKINE RECEPTORS AT DISTINCT DIFFERENTIATION STAGES OF T-HELPERS FROM PERIPHERAL BLOOD

Медицинская иммунология, 2016
Expression of chemokine receptors (CCR4, CCR6, CXCR3 and CXCR5) on T-helper (Th) cells at various levels of differentiation in a group of healthy volunteers (n = 52) was assessed on the basis of CD45RA and CD62L expression, using the eight-color flow ...
I. V. Kudryavtsev, A. G. Borisov, I. I. Krobinets, A. A. Savchenko, M. K. Serebriakova, Areg A. Totolian   +5 more
doaj   +1 more source

Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions

Allergy, EarlyView.
Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira, Lisa Holla, Sophia Björkander, Marie Kaarup Bek, Lorenz Wirth, Patrick A. Shearer, Jesper Säfholm, Erik Sachs, Mamdoh Al‐Ameri, Kasra Vali, Sandra Ekström, Erik Melén, Jenny Mjösberg, Christopher Andrew Tibbitt   +13 more
wiley   +1 more source

Selective Absence of Co‐Inhibitory Receptor‐Expressing CD4+ T Cells in Lungs of Obese House Dust Mite‐Allergic C57BL/6 Mice

Allergy, EarlyView.
Obesity altered the inflammatory phenotype of HDM‐induced allergic airway inflammation in C57BL/6 mice, indicated by changed BAL cell composition. Single‐cell CITE‐Seq identified the lack of a CD4+ T‐cell subcluster characterized by co‐inhibitory receptor expression in obese HDM‐exposed C57BL/6 mice.
Sarah Miethe, Daniel P. Potaczek, Kim Pauck, Andrea Berlin, Bilal Alashkar Alhamwe, Stefanie Hagner, Andrea Nist, Elke Pogge von Strandmann, Thorsten Stiewe, Paul Klemm, Hartmann Raifer, Clemens Thölken, Holger Garn   +12 more
wiley   +1 more source

Dual Repressive Function by Cip1, a Budding Yeast Analog of p21, in Cell-Cycle START Regulation

Frontiers in Microbiology, 2020
Cip1, a newly identified yeast analog of p21, is a Cln3-CDK inhibitor that negatively regulates cell-cycle START. However, its function remains poorly understood.
Pan Li, Pan Li, Xueqin Liu, Zhimin Hao, Zhimin Hao, Yanrong Jia, Xiangdong Zhao, Debao Xie, Jingao Dong, Jingao Dong, Fanli Zeng, Fanli Zeng   +11 more
doaj   +1 more source

Transcription regulation by the human Ccr4-Not proteins [PDF]

, 2004
Transcription by RNA polymerase II is a highly regulated process. Multiple protein complexes are involved in the regulation of mRNA synthesis. The Ccr4-Not complex regulates transcription at a global level and, most likely, requires other proteins to ...
Zwartjes, Catharina Geertruida Maria
core   +1 more source

The Ccr4-not complex regulates Skn7 through Srb10 kinase

, 2007
The Ccr4-Not complex is a multifunctional regulatory platform composed of nine subunits that controls diverse cellular events including mRNA degradation, protein ubiquitination, and transcription.
Lenssen, Eve, Azzouz, Nowel, Michel, Agnès, Landrieux, Emilie, Collart, Martine   +4 more
core   +1 more source

Spatial Transcriptomics Identifies Characteristic Immunological Niches in Atopic Dermatitis

Allergy, EarlyView.
Spatially organized immune niches containing mature migratory dendritic cells (mmDCs) and CD4+ T cells in atopic dermatitis lesions support localized T cell activation and may contribute to disease persistence. Spatial transcriptomics identifies conserved immune niches in atopic dermatitis lesions, characterized by close co‐localization of CD4+ T cells
Lina Gross, Lukas Bäriswyl, Erik Kupschke, Alexandra Wallimann, Hanne Hillen, Philipp Kirchner, Jivko Kamarashev, Martin Wartenberg, Claudio Rhyner, Christoph Schlapbach, Stephan Traidl, Mirjam Schenk   +11 more
wiley   +1 more source

Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation.

, 2010
The CCR4-NOT complex is the main enzyme catalyzing the deadenylation of mRNA. We have investigated the composition of this complex in Drosophila melanogaster by immunoprecipitation with a monoclonal antibody directed against NOT1. The CCR4, CAF1 (=POP2),
Sinz, A., Ihling, C., Temme, C., Chartier, A., Zhang, L.B., Kremmer, E., Zhang, L., Simonelig, M., Wahle, E.   +8 more
core   +1 more source

A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin

Nature Communications, 2017
Roquin proteins downregulate target mRNA expression by recruiting effectors such as the CCR4-NOT deadenylase complex. Here the authors provide molecular details of how Roquin proteins recruit the CCR4-NOT complex to repress the expression of its targets.
Annamaria Sgromo, Tobias Raisch, Praveen Bawankar, Dipankar Bhandari, Ying Chen, Duygu Kuzuoğlu-Öztürk, Oliver Weichenrieder, Elisa Izaurralde   +7 more
doaj   +1 more source