Results 61 to 70 of about 22,512 (231)

Role of Cnot6l in maternal mRNA turnover

Life Science Alliance, 2018
Mice lacking Cnot6l , a deadenylase component of the CCR4–NOT complex, are viable, but females have ∼40% smaller litters. Cnot6l is a maternal-effect gene acting in maternal mRNA degradation.
Filip Horvat, Helena Fulka, Radek Jankele, Radek Malik, Ma Jun, Katerina Solcova, Radislav Sedlacek, Kristian Vlahovicek, Richard M Schultz, Petr Svoboda   +9 more
doaj   +1 more source

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Aberrant CCR4 expression is involved in tumor invasion of lymph node-negative human gastric cancer. [PDF]

PLoS ONE, 2015
Cellular chemotaxis is the best-known function of chemokine receptors which are closely linked with tumor metastasis. In fact, positive expression of chemokine receptors could also be identified even in some patients without metastatic tumors, while the ...
Yongmei Yang, Lutao Du, Xiaoyun Yang, Ailin Qu, Xin Zhang, Chengjun Zhou, Chuanxin Wang   +6 more
doaj   +1 more source

An mRNA decapping mutant deficient in P body assembly limits mRNA stabilization in response to osmotic stress [PDF]

, 2017
Yeast is exposed to changing environmental conditions and must adapt its genetic program to provide a homeostatic intracellular environment. An important stress for yeast in the wild is high osmolarity.
A Totaro, A van Hoof, AD Aragon, AP Gasch, AR Albig, C Janke, C Miller, C Molin, CJ Decker, CJ Decker, CW Bourque, D Cao, D Melamed, D Teixeira, D Teixeira, D Zheng, E Garre, F Posas, G Gowrishankar, G Haas, G Haimovich, GR Pilkington, H Donis-Keller, J Coller, J Schindelin, J Warringer, J Yale, JA Arribere, JF Garcia, JF Garcia, JR Buchan, JR Buchan, JS Anderson, JS Bett, L Hatfield, L Romero-Santacreu, M Brengues, M Kshirsagar, M Rep, M Tucker, MAM Reijns, N Alhusaini, N Cougot, N Otsu, R Parker, S Hohmann, S Huch, S Jain, S Tharun, T Grousl, T Nissan, U Sheth, U Sheth, V Balagopal, V Hilgers, V Pelechano, V Pelechano, W Hu, Y Uesono   +58 more
core   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

CCR4/NOT complex associates with the proteasome and regulates histone methylation [PDF]

Proceedings of the National Academy of Sciences, 2007
The proteasome regulates histone lysine methylation and gene transcription, but how it does so is poorly understood. To better understand this process, we used the epistatic miniarray profile (E-MAP) approach to identify factors that genetically interact with proteasomal subunits.
R Nicholas, Laribee, Yoichiro, Shibata, Douglas P, Mersman, Sean R, Collins, Patrick, Kemmeren, Assen, Roguev, Jonathan S, Weissman, Scott D, Briggs, Nevan J, Krogan, Brian D, Strahl   +9 more
openaire   +2 more sources

The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. [PDF]

, 2016
BackgroundGene expression is controlled at multiple levels, including transcription, stability, translation, and degradation. Over the years, it has become apparent that Plasmodium falciparum exerts limited transcriptional control of gene expression ...
Batugedara, Gayani, Bunnik, Evelien M, Florens, Laurence, Le Roch, Karine G, Prudhomme, Jacques, Saraf, Anita   +5 more
core   +2 more sources

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Histone deacetylase inhibitors downregulate CCR4 expression and decrease mogamulizumab efficacy in CCR4-positive mature T-cell lymphomas

Haematologica, 2018
Histone deacetylase inhibitors are promising agents for various T-cell lymphomas, including cutaneous T-cell lymphoma, peripheral T-cell lymphoma, and adult T-cell lymphoma/leukemia. CCR4 is an important therapeutic target molecule because mogamulizumab,
Akihiro Kitadate, Sho Ikeda, Fumito Abe, Naoto Takahashi, Norio Shimizu, Kosei Matsue, Hiroyuki Tagawa   +6 more
doaj   +1 more source

The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb. [PDF]

, 2019
Overexpression of the oncogene MYBL2 (B-Myb) is associated with increased cell proliferation and serves as a marker of poor prognosis in cancer. However, the mechanism by which B-Myb alters the cell cycle is not fully understood.
Ananthapadmanabhan, Varsha, Dozmorov, Mikhail, Felthousen, Jessica, Guiley, Keelan Z, Iness, Audra N, Litovchick, Larisa, Rubin, Seth M, Saini, Siddharth, Sesay, Fatmata   +8 more
core