Results 81 to 90 of about 2,257 (136)
Mechanisms of mRNA substrate-selection by the Ccr4-Not deadenylase complex [PDF]
, 2017 The level to which genes are expressed depends on the rate at which the mRNA is generated, and the rate at which it is utilised and destroyed. Almost all eukaryotic mRNAs contain a stretch of adenosine nucleotides known as the poly(A) tail.
core +2 more sources
Immunology, EarlyView.During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu +24 more
wiley +1 more source
Alternative splicing of CNOT7 diversifies CCR4–NOT functions
, 2017 International audienceThe CCR4-associated factor CAF1, also called CNOT7, is a catalytic subunit of the CCR4–NOT complex , which has been implicated in all aspects of the mRNA life cycle, from mRNA synthesis in the nucleus to degradation in the cytoplasm.
Peng Wang +13 more
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Immunology, EarlyView.This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann +7 more
wiley +1 more source
The Ccr4-Not Complex: Architecture and Structural Insights
, 2017 The Ccr4-Not complex is an essential multi-subunit protein complex that plays a fundamental role in eukaryotic mRNA metabolism and has a multitude of different roles that impact eukaryotic gene expression .
Olesya O. Panasenko +3 more
core +1 more source
RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases
Frontiers in Cardiovascular Medicine, 2019 The increasing prevalence of worldwide obesity has emerged as a major risk factor for type 2 diabetes (T2D), hepatosteatosis, and cardiovascular disease. Accumulating evidence indicates that obesity has strong inflammatory underpinnings tightly linked to
Esam S. B. Salem +8 more
doaj +1 more source
Immune‐related adverse events with mogamulizumab in cutaneous T‐cell lymphoma: A multicentre study
Journal of the European Academy of Dermatology and Venereology, EarlyView.In a nationwide multicentre study of 403 patients with cutaneous T‐cell lymphoma treated with mogamulizumab, non‐MAR immune‐related adverse events were reported in 8.4% of patients across responding centres. These events were diverse, sometimes severe or persistent, and could occur late during mogamulizumab treatment.
David Neubauer +28 more
wiley +1 more source
Role of Ccr4-Not complex in heterochromatin formation at meiotic genes and subtelomeres in fission yeast. [PDF]
, 2015 BACKGROUND: Heterochromatin is essential for chromosome segregation, gene silencing and genome integrity. The fission yeast Schizosaccharomyces pombe contains heterochromatin at centromeres, subtelomeres, and mating type genes, as well as at small ...
Cristina Cotobal +7 more
core +2 more sources
Initial OX40–OX40L Signaling Promotes a Skin‐Resident Memory T‐Cell Reservoir in Atopic Dermatitis
Allergy, EarlyView.
Takayoshi Komatsu‐Fujii +6 more
wiley +1 more source
Etiology, pathogenesis and treatment of peri‐implantitis: A European perspective
Periodontology 2000, EarlyView.Abstract Peri‐implantitis is a plaque‐associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri‐implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri‐implantitis has become a major disease burden in dentistry.
Tord Berglundh +3 more
wiley +1 more source