Results 81 to 90 of about 22,512 (231)

Experimental and Computational Analysis of a Large Protein Network That Controls Fat Storage Reveals the Design Principles of a Signaling Network [PDF]

, 2015
An approach combining genetic, proteomic, computational, and physiological analysis was used to define a protein network that regulates fat storage in budding yeast (Saccharomyces cerevisiae). A computational analysis of this network shows that it is not
Al-Anzi, Bader, Arpp, Patrick, Gerges, Sherif, Olsman, Noah, Ormerod, Christopher, Zinn, Kai   +5 more
core   +3 more sources

T cell plasticity in systemic lupus erythematosus revealed by large‐scale T cell receptor repertoire and transcriptome studies

Arthritis &Rheumatology, Accepted Article.
Objective We aimed to characterize CD4+ T cell plasticity in human SLE by leveraging TCR repertoire features as markers of prior lineage states, integrating TCR and transcriptomic profiling to delineate plasticity patterns and evaluate their association with clinical disease activity.
Yasuo Nagafuchi, Masahiro Nakano, Kaitlyn A. Lagattuta, Mineto Ota, Hiroaki Hatano, Haruka Takahashi, Takahiro Itamiya, Hajime Inokuchi, Soumya Raychaudhuri, Tomohisa Okamura, Keishi Fujio, Kazuyoshi Ishigaki   +11 more
wiley   +1 more source

HELZ directly interacts with CCR4–NOT and causes decay of bound mRNAs [PDF]

Life Science Alliance, 2019
Eukaryotic superfamily (SF) 1 helicases have been implicated in various aspects of RNA metabolism, including transcription, processing, translation, and degradation. Nevertheless, until now, most human SF1 helicases remain poorly understood. Here, we have functionally and biochemically characterized the role of a putative SF1 helicase termed “helicase ...
Aoife Hanet, Felix Räsch, Ramona Weber, Vincenzo Ruscica, Maria Fauser, Tobias Raisch, Duygu Kuzuoğlu-Öztürk, Chung-Te Chang, Dipankar Bhandari, Cátia Igreja, Lara Wohlbold   +10 more
openaire   +4 more sources

Disruption of the Mammalian Ccr4–Not Complex Contributes to Transcription-Mediated Genome Instability

Cells, 2023
The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression.
Nafiseh Chalabi Hagkarim, Morteza Chalabi Hajkarim, Toru Suzuki, Toshinobu Fujiwara, G. Sebastiaan Winkler, Grant S. Stewart, Roger J. Grand   +6 more
doaj   +1 more source

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, EarlyView.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

The control of elongation by the yeast Ccr4–Not complex [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
The Ccr4-Not complex is a highly conserved nine-subunit protein complex that has been implicated in virtually all aspects of gene control, including transcription, mRNA decay and quality control, RNA export, translational repression and protein ubiquitylation.
openaire   +2 more sources

Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics' [PDF]

, 2005
We combined large-scale mRNA expression analysis and gene mapping to identify genes and loci that control hematopoietic stem cell (HSC) function. We measured mRNA expression levels in purified HSCs isolated from a panel of densely genotyped recombinant ...
A Scherer, CE Muller-Sieburg, CS Potten, EE Schadt, ES Lander, F Lai, G de Haan, G De Haan, G De Haan, G Yvert, J Boultwood, J Klose, JL Peirce, LM Kamminga, M Ramalho-Santos, ML Wayne, NB Ivanova, NO Fortunel, P Hasty, RB Brem, RC Jansen, RC Jansen, SR Pearce, T Wiltshire, Y Ben-David   +24 more
core   +2 more sources

Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang, Teng‐Fei Li, Tian‐Yu Wang, Huan‐Hai Liu   +3 more
wiley   +1 more source

CCL17‐CCR4 axis contributes to the onset of vitiligo in mice

Immunity, Inflammation and Disease, 2021
Background Destruction of melanocytes mediated by autoimmunity is currently believed as the main cause of vitiligo. This article aims to identify the role of CC chemokine ligand 17 (CCL17)–CC chemokine receptor 4 (CCR4) axis in vitiligo and provide new ...
He Li, Congpin Wang, Xiaoqing Li, Yinghui Kong, Weiguo Sun   +4 more
doaj   +1 more source

A core-attachment based method to detect protein complexes in PPI networks [PDF]

, 2009
Background How to detect protein complexes is an important and challenging task in post genomic era. As the increasing amount of protein-protein interaction (PPI) data are available, we are able to identify protein complexes from PPI networks.
Min Wu, Xiaoli Li, Chee-Keong Kwoh, See-Kiong Ng   +3 more
core   +1 more source