Results 21 to 30 of about 9,376 (189)

Transient translational silencing by reversible mRNA deadenylation

Cell, 1992
Tissue-type plasminogen activator (tPA) mRNA is stored, stable and untranslated, in the cytoplasm of fully grown primary mouse oocytes. Dormancy is associated with an unusually short poly(A) tail, and poly(A) tail elongation controls tPA mRNA ...
Sidney Strickland, Pascale Gubler, Darrow, A. L., Belin, Dominique, Strickland, S., Huarte, Joachim, O'Connell, M. L., Vassalli, Jean-Dominique, Dominique Belin, Andrew L. Darrow, Stutz, A., Jean-Dominique Vassalli, André Stutz, Gubler, P., Joaquin Huarte, Marcia L. O'Connell   +15 more
core   +4 more sources

Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications. [PDF]

Wiley Interdiscip Rev RNA
Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Felicitus S, Pinto SS, Madagundapalli Ramakrishna SS, Nanjappa DP, Chakraborty G, Chakraborty A.   +5 more
europepmc   +2 more sources

ER-Localized Deadenylase <i>PNLDC1</i> Suppresses Colorectal Cancer Progression by Targeting the mRNA Decay of <i>TUBB4B</i>. [PDF]

Exploration (Beijing)
The deficiency of PNLDC1 exacerbates the advancement of CRC. PNLDC1 interacts with TUBB4B mRNA to regulate the p53–p21–CDK2–cyclin E2 pathway, thereby influencing the G2/M phase of the cell cycle. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, highlighting the urgent need for novel therapeutic strategies.
Liu L, Guan Y, Qin Y, Chen G, Wang G, Yan X, Li X, Sun L, Yu W, Ouyang S, Ma Z, Xu Z, Cao Z, Yu F, Zhou T, Luo Z, Chen X, Yan Y, Hu L.   +18 more
europepmc   +2 more sources

To polyadenylate or to deadenylate [PDF]

Cell Cycle, 2010
mRNA polyadenylation and deadenylation are important processes that allow rapid regulation of gene expression in response to different cellular conditions. Almost all eukaryotic mRNA precursors undergo a co-transcriptional cleavage followed by polyadenylation at the 3' end.
Xiaokan, Zhang, Anders, Virtanen, Frida E, Kleiman   +2 more
openaire   +2 more sources

Deadenylation—a piece of PANcake [PDF]

The EMBO Journal, 2014
Pan is a poly(A)‐specific 3′ exoribonuclease that, together with the CCR4‐NOT complex, is responsible for initiating and controlling mRNA decay by degradation of the poly(A) tail. Now, more than twenty years after the enzyme's discovery, a surge of recent papers, including one in this issue of The EMBO Journal (Wolf et al , [2014][1]) has revealed ...
Milton T, Stubbs, Elmar, Wahle
openaire   +2 more sources

mRNA deadenylation by Pan2–Pan3 [PDF]

Biochemical Society Transactions, 2014
Poly(A) tails are important regulators of mRNA stability and translational efficiency. Cytoplasmic removal of poly(A) tails by 3′→5′ exonucleases (deadenylation) is the rate-limiting step in mRNA degradation. Two exonuclease complexes contribute the majority of the deadenylation activity in eukaryotes: Ccr4–Not and Pan2–Pan3.
Wolf J, Passmore LA.
openaire   +2 more sources

Interaction between NANOS2 and the CCR4-NOT deadenylation complex is essential for male germ cell development in mouse. [PDF]

PLoS ONE, 2012
Nanos is one of the evolutionarily conserved proteins implicated in germ cell development and we have previously shown that it interacts with the CCR4-NOT deadenylation complex leading to the suppression of specific RNAs. However, the molecular mechanism
Atsushi Suzuki, Rie Saba, Kei Miyoshi, Yoshinori Morita, Yumiko Saga   +4 more
doaj   +1 more source

Mechanisms of deadenylation‐dependent decay [PDF]

WIREs RNA, 2010
AbstractDegradation of messenger RNAs (mRNAs) plays an essential role in modulation of gene expression and in quality control of mRNA biogenesis. Nearly all major mRNA decay pathways characterized thus far in eukaryotes are initiated by deadenylation, i.e., shortening of the mRNA 3′ poly(A) tail.
Chyi-Ying A, Chen, Ann-Bin, Shyu
openaire   +2 more sources

The Regulatory Properties of the Ccr4–Not Complex

Cells, 2020
The mammalian Ccr4–Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene expression.
Nafiseh Chalabi Hagkarim, Roger J. Grand
doaj   +1 more source

mRNA deadenylation and telomere disease [PDF]

Journal of Clinical Investigation, 2015
Dyskeratosis congenita (DC) is an inherited BM failure disorder that is associated with mutations in genes involved with telomere function and maintenance; however, the genetic cause of many instances of DC remains uncharacterized. In this issue of the JCI, Tummala and colleagues identify mutations in the gene encoding the poly(A)-specific ribonuclease
Philip J, Mason, Monica, Bessler
openaire   +3 more sources