Results 21 to 30 of about 7,761 (122)

Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails

eLife, 2020
La-related protein 4 (LARP4) directly binds both poly(A) and poly(A)-binding protein (PABP). LARP4 was shown to promote poly(A) tail (PAT) lengthening and stabilization of individual mRNAs presumably by protection from deadenylation (Mattijssen et al ...
Sandy Mattijssen, James R Iben, Tianwei Li, Steven L Coon, Richard J Maraia   +4 more
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The BTG4 and CAF1 complex prevents the spontaneous activation of eggs by deadenylating maternal mRNAs [PDF]

Open Biology, 2016
Once every menstrual cycle, eggs are ovulated into the oviduct where they await fertilization. The ovulated eggs are arrested in metaphase of the second meiotic division, and only complete meiosis upon fertilization. It is crucial that the maintenance of
Michał Pasternak, Sybille Pfender, Balaji Santhanam, Melina Schuh   +3 more
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Rous Sarcoma Virus RNA Stability Element Inhibits Deadenylation of mRNAs with Long 3′UTRs

Viruses, 2017
All retroviruses use their full-length primary transcript as the major mRNA for Group-specific antigen (Gag) capsid proteins. This results in a long 3′ untranslated region (UTR) downstream of the termination codon. In the case of Rous sarcoma virus (RSV),
Vidya Balagopal, Karen L. Beemon
doaj   +1 more source

HPat a decapping activator interacting with the miRNA effector complex.

PLoS ONE, 2013
Animal miRNAs commonly mediate mRNA degradation and/or translational repression by binding to their target mRNAs. Key factors for miRNA-mediated mRNA degradation are the components of the miRNA effector complex (AGO1 and GW182) and the general mRNA ...
Elisabeth Barišić-Jäger, Izabela Kręcioch, Stefanie Hosiner, Sanja Antic, Silke Dorner   +4 more
doaj   +1 more source

Deadenylation of mRNA by the CCR4-NOT complex in Drosophila: molecular and developmental aspects

Frontiers in Genetics, 2014
Controlled shortening of the poly(A) tail of mRNAs is the first step in eukaryotic mRNA decay and can also be used for translational inactivation of mRNAs.
Claudia eTemme, Martine eSimonelig, Elmar eWahle   +2 more
doaj   +1 more source

Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN)

Cells, 2020
Translation is spatiotemporally regulated and endoplasmic reticulum (ER)-associated mRNAs are generally in efficient translation. It is unclear whether the ER-associated mRNAs are deadenylated or degraded on the ER surface in situ or in the cytosol. Here,
Tian-Li Duan, Han Jiao, Guang-Jun He, Yong-Bin Yan   +3 more
doaj   +1 more source

Post-transcriptional Stabilization of Ucp1 mRNA Protects Mice from Diet-Induced Obesity

Cell Reports, 2015
Uncoupling protein 1 (Ucp1) contributes to thermogenesis, and its expression is regulated at the transcriptional level. Here, we show that Ucp1 expression is also regulated post-transcriptionally.
Akinori Takahashi, Shungo Adachi, Masahiro Morita, Miho Tokumasu, Tohru Natsume, Toru Suzuki, Tadashi Yamamoto   +6 more
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Mitochondrial dysfunction reveals the role of mRNA poly(A) tail regulation in oculopharyngeal muscular dystrophy pathogenesis. [PDF]

PLoS Genetics, 2015
Oculopharyngeal muscular dystrophy (OPMD), a late-onset disorder characterized by progressive degeneration of specific muscles, results from the extension of a polyalanine tract in poly(A) binding protein nuclear 1 (PABPN1).
Aymeric Chartier, Pierre Klein, Stéphanie Pierson, Nicolas Barbezier, Teresa Gidaro, François Casas, Steven Carberry, Paul Dowling, Laurie Maynadier, Maëlle Bellec, Martine Oloko, Claude Jardel, Bodo Moritz, George Dickson, Vincent Mouly, Kay Ohlendieck, Gillian Butler-Browne, Capucine Trollet, Martine Simonelig   +18 more
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RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts

Open Biology, 2023
Alpha-synuclein (SNCA) accumulation plays a central role in the pathogenesis of Parkinson's disease. Determining and interfering with the mechanisms that control SNCA expression is one approach to limiting disease progression.
Fedon-Giasin Kattan, Pelagia Koukouraki, Athanasios K. Anagnostopoulos, George T. Tsangaris, Epaminondas Doxakis   +4 more
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Dynamic Control of Dendritic mRNA Expression by CNOT7 Regulates Synaptic Efficacy and Higher Cognitive Function

Cell Reports, 2017
Translation of mRNAs in dendrites mediates synaptic plasticity, the probable cellular basis of learning and memory. Coordination of translational inhibitory and stimulatory mechanisms, as well as dendritic transport of mRNA, is necessary to ensure proper
Rhonda L. McFleder, Fernanda Mansur, Joel D. Richter   +2 more
doaj   +1 more source