Results 21 to 30 of about 14,275 (206)
Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex
Frontiers in Cell and Developmental Biology, 2023 Accurate and precise regulation of gene expression programmes in eukaryotes involves the coordinated control of transcription, mRNA stability and translation.
Lorenzo Pavanello +2 more
doaj +1 more source
Traffic into silence: endomembranes and post-transcriptional RNA silencing. [PDF]
, 2014 microRNAs (miRNAs) and small interfering RNAs (siRNAs) are small RNAs that repress gene expression at the post-transcriptional level in plants and animals. Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequence-
Chen, Xuemei +2 more
core +6 more sources
Mechanisms of deadenylation‐dependent decay [PDF]
WIREs RNA, 2010 AbstractDegradation of messenger RNAs (mRNAs) plays an essential role in modulation of gene expression and in quality control of mRNA biogenesis. Nearly all major mRNA decay pathways characterized thus far in eukaryotes are initiated by deadenylation, i.e., shortening of the mRNA 3′ poly(A) tail.
Chyi-Ying A, Chen, Ann-Bin, Shyu
openaire +2 more sources
A functional deadenylation assay identifies human CUG‐BP as a deadenylation factor [PDF]
Biology of the Cell, 2003 Abstract CUG‐BP is a human nuclear and cytoplasmic RNA‐binding protein. A role in the control of alternative splicing has been reported, but to date no cytoplasmic function for this protein has been demonstrated. A close sequence homolog of CUG‐BP is EDEN‐BP that is required for the specific cytoplasmic poly(A) tail shortening of certain mRNAs after ...
Paillard, Luc +2 more
openaire +2 more sources
The Dynamic Poly(A) Tail Acts as a Signal Hub in mRNA Metabolism
Cells, 2023 In eukaryotes, mRNA metabolism requires a sophisticated signaling system. Recent studies have suggested that polyadenylate tail may play a vital role in such a system.
Guiying Zhang +4 more
doaj +1 more source
Deadenylation and P-Bodies [PDF]
, 2012 Deadenylation is the major step in triggering mRNA decay and results in mRNA translation inhibition in eukaryotic cells. Therefore, it is plausible that deadenylation also induces the mRNP remodeling required for formation of GW bodies or RNA processing bodies (P-bodies), which harbor translationally silenced mRNPs.
Chyi-Ying A, Chen, Ann-Bin, Shyu
openaire +2 more sources
Cap-dependent deadenylation of mRNA [PDF]
The EMBO Journal, 2000 Poly(A) tail removal is often the initial and rate-limiting step in mRNA decay and is also responsible for translational silencing of maternal mRNAs during oocyte maturation and early development. Here we report that deadenylation in HeLa cell extracts and by a purified mammalian poly(A)-specific exoribonuclease, PARN (previously designated ...
E, Dehlin +3 more
openaire +2 more sources
Viruses and the cellular RNA decay machinery. [PDF]
, 2010 The ability to control cellular and viral gene expression, either globally or selectively, is central to a successful viral infection, and it is also crucial for the host to respond and eradicate pathogens.
Gaglia, Marta, Glaunsinger, Britt
core +1 more source
Oligomerization of EDEN-BP is required for specific mRNA deadenylation and binding. [PDF]
, 2006 International audienceBACKGROUND INFORMATION: mRNA deadenylation [shortening of the poly(A) tail] is often triggered by specific sequence elements present within mRNA 3' untranslated regions and generally causes rapid degradation of the mRNA.
Aït-Ahmed, Ounissa +6 more
core +3 more sources
A novel class of microRNA-recognition elements that function only within open reading frames. [PDF]
, 2018 MicroRNAs (miRNAs) are well known to target 3' untranslated regions (3' UTRs) in mRNAs, thereby silencing gene expression at the post-transcriptional level.
A Aizer +85 more
core +2 more sources