Results 71 to 80 of about 156,480 (199)
Competitive effects in bacterial mRNA decay
Journal of Theoretical Biology, 2020 In living organisms, the same enzyme catalyses the degradation of thousands of different mRNAs, but the possible influence of competing substrates has been largely ignored so far. We develop a simple mechanistic model of the coupled degradation of all cell mRNAs using the total quasi-steady-state approximation of the Michaelis-Menten framework ...
Etienne, Thibault +2 more
openaire +5 more sources
The 5'-3' exoribonuclease pacman is required for epithelial sheet sealing in Drosophila and genetically interacts with the phosphatase puckered [PDF]
, 2008 Background information. Ribonucleases have been well studied in yeast and bacteria, but their biological significance to developmental processes in multicellular organisms is not well understood.
Browne, Cathy +7 more
core +2 more sources
Nonsense-mediated mRNA decay in mammals [PDF]
Journal of Cell Science, 2005 Nonsense-mediated mRNA decay (NMD) in mammalian cells generally degrades mRNAs that terminate translation more than 50-55 nucleotides upstream of a splicing-generated exon-exon junction (reviewed in [Maquat, 2004a][1]; [Nagy and Maquat, 1998][2]).
openaire +2 more sources
A Low Dimensional Approximation For Competence In Bacillus Subtilis
, 2015 The behaviour of a high dimensional stochastic system described by a Chemical Master Equation (CME) depends on many parameters, rendering explicit simulation an inefficient method for exploring the properties of such models.
Dasmahapatra, Srinandan +2 more
core +1 more source
Investigating the mechanism behind the feedback regulation of the Exon Junction Complex component MAGOH [PDF]
, 2020 RNA binding proteins are critical for regulation of RNA function, and therefore maintaining appropriate levels of these proteins is important for cellular regulation.
Nega, Abigail
core
Identification of a novel human E-Cadherin splice variant andassessment of its effects upon EMT-related events [PDF]
, 2018 Epithelial Cadherin (E-cadherin) is involved in calcium-dependent cell-cell adhesion and signal transduction. The E-cadherin decrease/loss is a hallmark of Epithelial to Mesenchymal Transition (EMT), a key event in tumor progression.
Besso, María José +8 more
core +1 more source
Mechanisms of endonuclease‐mediated mRNA decay [PDF]
WIREs RNA, 2011 AbstractEndonuclease cleavage was one of the first identified mechanisms of mRNA decay but until recently it was thought to play a minor role to the better‐known processes of deadenylation, decapping, and exonuclease‐catalyzed decay. Most of the early examples of endonuclease decay came from studies of a particular mRNA whose turnover changed in ...
openaire +2 more sources
Robust filtering for stochastic genetic regulatory networks with time-varying delay [PDF]
, 2009 This is the post print version of the article. The official published version can be obtained from the link - Copyright 2009 Elsevier LtdThis paper addresses the robust filtering problem for a class of linear genetic regulatory networks (GRNs) with ...
Fraser, K +5 more
core +1 more source
PLoS Pathogens, 2020 In mammalian cells, widespread acceleration of cytoplasmic mRNA degradation is linked to impaired RNA polymerase II (Pol II) transcription. This mRNA decay-induced transcriptional repression occurs during infection with gammaherpesviruses including ...
Ella Hartenian +4 more
doaj +1 more source
Suppressing nonsense--a surprising function for 5-azacytidine. [PDF]
, 2014 In this issue of EMBO Molecular Medicine, Bhuvanagiri et al report on a chemical means to convert molecular junk into gold. They identify a chemical inhibitor of a quality control pathway that is best known for its ability to clear cells of rubbish, but ...
Shao, Ada, Wilkinson, Miles F
core +2 more sources