Results 1 to 10 of about 6,248 (149)
Zdorovʹe Rebenka, 2022 The scientific review presents the mechanisms of action of cytoplasmic miRNAs, namely the relationship between miRNA and mRNA molecules and the influence of miRNAs on translation.
A.E. Abaturov, V.L. Babуch
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Extensive translatome remodeling during ER stress response in mammalian cells. [PDF]
PLoS ONE, 2012 In this work we have described the translatome of two mammalian cell lines, NIH3T3 and Jurkat, by scoring the relative polysome association of ∼10,000 mRNA under normal and ER stress conditions.
Iván Ventoso +4 more
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Exploration of Targeted Anti-tumor Therapy, 2020 Cancer development is frequently associated with dysregulation of mRNA translation to enhance both increased global protein synthesis and translation of specific mRNAs encoding oncoproteins.
Joe Taylor +2 more
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Regulation of gene expression in trypanosomatids: living with polycistronic transcription [PDF]
Open Biology, 2019 In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are excised by trans-splicing and polyadenylation. The lack of individual gene transcription control is compensated by control of mRNA processing, translation and ...
Christine Clayton
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Cap-Independent Circular mRNA Translation Efficiency
Vaccines, 2023 Recently, the mRNA platform has become the method of choice in vaccine development to find new ways to fight infectious diseases. However, this approach has shortcomings, namely that mRNA vaccines require special storage conditions, which makes them less
Andrei A. Deviatkin +9 more
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Emerging role of mRNA epitranscriptomic regulation in chemoresistant cancer cells
Molecular & Cellular Oncology, 2020 Cancer persister cells remain a significant barrier to effective anti-cancer therapy. We found that melanoma persister cells undergo a reversible reprogramming of mRNA translation.
Shensi Shen, Xiaoxiao Sun
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Вавиловский журнал генетики и селекции, 2021 The expression of eukaryotic genes can be regulated at several stages, including the translation of mRNA. It is known that the structure of mRNA can affect both the efficiency of interaction with the translation apparatus in general and the choice of ...
D. A. Afonnikov +4 more
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Secondary Structure across the Bacterial Transcriptome Reveals Versatile Roles in mRNA Regulation and Function. [PDF]
PLoS Genetics, 2015 Messenger RNA acts as an informational molecule between DNA and translating ribosomes. Emerging evidence places mRNA in central cellular processes beyond its major function as informational entity.
Cristian Del Campo +3 more
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The long non-coding RNA GAS5 cooperates with the eukaryotic translation initiation factor 4E to regulate c-Myc translation. [PDF]
PLoS ONE, 2014 Long noncoding RNAs (lncRNAs) are important regulators of transcription; however, their involvement in protein translation is not well known. Here we explored whether the lncRNA GAS5 is associated with translation initiation machinery and regulates ...
Guangzhen Hu, Zhenkun Lou, Mamta Gupta
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Regulation of mRNA Translation Is a Novel Mechanism for Phthalate Toxicity. [PDF]
PLoS ONE, 2016 Phthalates are a group of plasticizers that are widely used in many consumer products and medical devices, thus generating a huge burden to human health. Phthalates have been known to cause a number of developmental and reproductive disorders functioning
Jun Ling +4 more
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