Results 11 to 20 of about 405,975 (264)
The strategies and advances of mRNA translation booster [PDF]
Asian Journal of Pharmaceutical SciencesThe therapeutic efficacy and safety of mRNA-based drugs in immunological and nonimmunological applications are critically dependent on the translated protein yield, which requires precise modulation of mRNA expression kinetics.
Yingying Shi +5 more
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Heterogeneity in mRNA Translation [PDF]
Trends in Cell Biology, 2020 During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different mRNA molecules derived from a ...
Stijn, Sonneveld +2 more
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Sensitivity of mRNA Translation [PDF]
Scientific Reports, 2015 AbstractUsing the dynamic mean-field approximation of the totally asymmetric simple exclusion process (TASEP), we investigate the effect of small changes in the initiation, elongation and termination rates along the mRNA strand on the steady-state protein translation rate.
Gilad Poker +2 more
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MicroRNAs, mRNAs, and Translation [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2006 MicroRNAs (miRNAs) comprise a large family of regulatory molecules that repress protein production from targeted mRNAs. Although it is now clear that miRNAs exert pervasive effects on gene expression in animal cells, the mechanism(s) by which they function remains poorly understood.
P A, Maroney, Y, Yu, T W, Nilsen
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Extensive translatome remodeling during ER stress response in mammalian cells. [PDF]
PLoS ONE, 2012 In this work we have described the translatome of two mammalian cell lines, NIH3T3 and Jurkat, by scoring the relative polysome association of ∼10,000 mRNA under normal and ER stress conditions.
Iván Ventoso +4 more
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Zdorovʹe Rebenka, 2022 The scientific review presents the mechanisms of action of cytoplasmic miRNAs, namely the relationship between miRNA and mRNA molecules and the influence of miRNAs on translation.
A.E. Abaturov, V.L. Babуch
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Translation initiation of viral mRNAs [PDF]
Reviews in Medical Virology, 2010 AbstractViruses depend on cells for their replication but have evolved mechanisms to achieve this in an efficient and, in some instances, a cell‐type‐specific manner. The expression of viral proteins is frequently subject to translational control. The dominant target of such control is the initiation step of protein synthesis.
Lopez-Lastra, Marcelo +5 more
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Journal of the American Society of Nephrology, 2006 Ambient protein levels are under coordinated control of transcription, mRNA translation, and degradation. Whereas transcription and degradation mechanisms have been studied in depth in renal science, the role of mRNA translation, the process by which peptide synthesis occurs according to the genetic code that is present in the mRNA, has not received ...
Balakuntalam S, Kasinath +4 more
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Exploration of Targeted Anti-tumor Therapy, 2020 Cancer development is frequently associated with dysregulation of mRNA translation to enhance both increased global protein synthesis and translation of specific mRNAs encoding oncoproteins.
Joe Taylor +2 more
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Cap-Independent Circular mRNA Translation Efficiency
Vaccines, 2023 Recently, the mRNA platform has become the method of choice in vaccine development to find new ways to fight infectious diseases. However, this approach has shortcomings, namely that mRNA vaccines require special storage conditions, which makes them less
Andrei A. Deviatkin +9 more
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