Results 11 to 20 of about 1,257,185 (207)

Exploring the Impact of mRNA Modifications on Translation Efficiency and Immune Tolerance to Self-Antigens

Vaccines
Therapeutic modified mRNAs are being developed for a broad range of human diseases. However, the impact of potential miscoding of modified mRNAs on self-tolerance remains unknown. Additionally, more studies are needed to explore the effects of nucleoside
Mouldy Sioud, Asta Juzeniene, Stein Sæbøe-Larssen   +2 more
doaj   +2 more sources

SRAG Functions as a New mRNA Export Co-adaptor [PDF]

, 2012
DEAD box RNA helicases play important roles in many cellular processes including splicing, mRNA export and translation. The two domains of many DEAD box RNA helicases adopt radically different conformations according to whether they are ...
Chang, Chung-Te
core   +6 more sources

Specialized Yeast Ribosomes: A Customized Tool for Selective mRNA Translation [PDF]

, 2013
Evidence is now accumulating that sub-populations of ribosomes - so-called specialized ribosomes - can favour the translation of subsets of mRNAs. Here we use a large collection of diploid yeast strains, each deficient in one or other copy of the set of ...
Klausegger, Alfred, Brandl Clemens, Lore Breitenbach-Koller, Clemens Br, Bjoern Wimmer (431586), Mick F, Wimmer, Bjoern, Johann W. Bauer (431583), Manuela Weber, Clemens Brandl, Tuite Mick F., Breitenbach-Koller, Hannelore, Klausegger Alfred, Manuela Weber (431587), Johann W. Bauer, Bauer Johann W., Breitenbach-Koller, Lore, Haubenreisser Olaf, Preiss, Thomas, Breitenbach-Koller Lore, Wimmer Bjoern, Helmut Hintner, Michael Breitenbach, Olaf Haubenreisser (431585), Hintner Helmut, Breitenbach, Michael, Mick F Tuite, Alfred Klausegger, Karl Thomas, Weber Manuela, Karl, Thomas, Hintner, Helmut, Bjoern Wimmer, Haar, Thomas Von der, Haubenreisser, Olaf, von der Haar Tobias, Clemens Brandl (431584), Bauer, Johann W., Johann W Bauer, Breitenbach Michael, Thomas Karl, Mick F. Tuite (266570), Lore Breitenbach-Koller (431591), Michael Breitenbach (46789), Bauer, Johann, Tuite, Mick F., von der Haar, Tobias, Olaf Haubenreisser, Helmut Hintner (431590), Brandl, Clemens, Tobias von der Haar, Tobias von der Haar (80575), Alfred Klausegger (431589), Thomas Karl (431588), Weber, Manuela   +54 more
core   +2 more sources

Folding transitions during assembly of the eukaryotic mRNA cap-binding complex. [PDF]

, 2006
The cap-binding protein eIF4E is the first in a chain of translation initiation factors that recruit 40S ribosomal subunits to the 5' end of eukaryotic mRNA. During cap-dependent translation, this protein binds to the 5'-terminal m(7)Gppp cap of the mRNA,
von der Haar, Tobias, Ptushkina, Marina, Wagner, Gerhard, McCarthy, John E G, Moerke, Nathan, Oku, Yuko, McCarthy, John E. G., Mccarthy, John, Gross, John D.   +8 more
core   +1 more source

Interaction of yeast eIF4G with spliceosome components Implications in pre-mRNA processing events [PDF]

, 2009
As evidenced from mammalian cells the eukaryotic translation initiation factor eIF4G has a putative role in nuclear RNA metabolism. Here we investigate whether this role is conserved in the yeast Saccharomyces cerevisiae.
Lewis, Joe, Fromont-Racine, Micheline, Thompson, Elizabeth, Jacquier, Alain, Beggs, Jean, D., Barrass, J. David, Beggs, Jean D., Kafasla, Panagiota   +7 more
core   +1 more source

A Comprehensive, Quantitative, and Genome-Wide Model of Translation [PDF]

, 2010
Translation is still poorly characterised at the level of individual proteins and its role in regulation of gene expression has been constantly underestimated.
Piotr Zielenkiewicz, Siwiak, Marlena, Marlena Siwiak, Zielenkiewicz, Piotr   +3 more
core   +1 more source

Mathematical and Computational Modelling of Ribosomal Movement and Protein Synthesis: an overview [PDF]

, 2012
Translation or protein synthesis consists of a complex system of chemical reactions, which ultimately result in decoding of the mRNA and the production of a protein.
von der Haar, Tobias, Tobias von der Haar   +1 more
core   +1 more source

Systemic Reprogramming of Translation Efficiencies on Oxygen Stimulus

Cell Reports, 2016
Protein concentrations evolve under greater evolutionary constraint than mRNA levels. Translation efficiency of mRNA represents the chief determinant of basal protein concentrations.
J.J. David Ho, Miling Wang, Timothy E. Audas, Deukwoo Kwon, Steven K. Carlsson, Sara Timpano, Sonia L. Evagelou, Shaun Brothers, Mark L. Gonzalgo, Jonathan R. Krieger, Steven Chen, James Uniacke, Stephen Lee   +12 more
doaj   +1 more source

Geneticin reduces mRNA stability.

PLoS ONE, 2022
Messenger RNA (mRNA) translation can lead to higher rates of mRNA decay, suggesting the ribosome plays a role in mRNA destruction. Furthermore, mRNA features, such as codon identities, which are directly probed by the ribosome, correlate with mRNA decay ...
Yavuz T Durmaz, Alankrit Shatadal, Kyle Friend   +2 more
doaj   +1 more source

Cellular mRNAs access second ORFs using a novel amino acid sequence-dependent coupled translation termination-reinitiation mechanism [PDF]

, 2014
Polycistronic transcripts are considered rare in the human genome. Initiation of translation of internal ORFs of eukaryotic genes has been shown to use either leaky scanning or highly structured IRES regions to access initiation codons.
Dyer, Nigel P., Croft, Wayne D., Gould, Phillip S., Easton, A. J. (Andrew J.), Ott, Sascha   +4 more
core   +1 more source