Results 1 to 10 of about 1,741,252 (219)

A novel chromatin-remodeling complex variant, dcPBAF, is involved in maintaining transcription in differentiated neurons

Frontiers in Cell and Developmental Biology, 2023
The Polybromo-associated BAF (BRG1- or BRM-associated factors) (PBAF) chromatin-remodeling complex is essential for transcription in mammalian cells.
Nataliya V. Soshnikova, Nataliya V. Soshnikova, Nataliya V. Soshnikova, Asya M. Azieva, Asya M. Azieva, Nataliya S. Klimenko, Alvina I. Khamidullina, Alexey V. Feoktistov, Alexey V. Feoktistov, Andrey A. Sheynov, Alexander V. Brechalov, Victor V. Tatarskiy, Sofia G. Georgieva   +12 more
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Structural basis of copper-efflux-regulator-dependent transcription activation

iScience, 2021
Summary: The copper efflux regulator (CueR), a representative member of mercury resistance regulator (MerR) family metalloregulators, controls expression of copper homeostasis-regulating genes in bacteria.
Wei Shi, Baoyue Zhang, Yanan Jiang, Chang Liu, Wei Zhou, Ming Chen, Yang Yang, Yangbo Hu, Bin Liu   +8 more
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The sequential phosphorylation of PHF10 subunit of the PBAF chromatin-remodeling complex determines different properties of the PHF10 isoforms

Biology Open, 2020
The mammalian PBAF subfamily of SWI/SNF chromatin remodeling complexes plays a wide role in the regulation of gene expression. PHF10 is a subunit of the signature module of PBAF, responsible for its interaction with chromatin.
Andrey A. Sheynov, Victor V. Tatarskiy, Eugene V. Tatarskiy, Elena N. Nabirochkina, Sofia G. Georgieva, Nataliya V. Soshnikova   +5 more
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Structural visualization of transcription activated by a multidrug-sensing MerR family regulator

Nature Communications, 2021
The MerR family of transcriptional regulators, such as EcmrR, activate promoters with a structure that is suboptimal for recognition by RNA polymerase holoenzyme. Structural insights into the EcmrR-dependent transcription process elucidate the mechanisms
Yang Yang, Chang Liu, Wei Zhou, Wei Shi, Ming Chen, Baoyue Zhang, David G. Schatz, Yangbo Hu, Bin Liu   +8 more
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Bridging the Gap Between Morphometric Similarity Mapping and Gene Transcription in Alzheimer’s Disease

Frontiers in Neuroscience, 2021
Disruptions in brain connectivity have been widely reported in Alzheimer’s disease (AD). Morphometric similarity (MS) mapping provides a new way of estimating structural connectivity by interregional correlation of T1WI- and DTI-derived parameters within
Yang Zhang, Min Ma, Zhonghua Xie, Heng Wu, Nan Zhang, Junlin Shen   +5 more
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Different functions of PHF10 isoforms – subunits of the PBAF chromatin remodeling complex

Вавиловский журнал генетики и селекции, 2019
Chromatin remodelling multiprotein complexes play an important role in regulation of gene expression in embryogenesis and in the adult organism. Mutations in the subunits of the complexes are often lethal or lead to developmental defects.
A. A. Sheynov, V. V. Tatarskiy, A. M. Azieva, S. G. Georgieva, N. V. Soshnikova   +4 more
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The role and mechanism of histone lactylation in health and diseases

Frontiers in Genetics, 2022
Whether under anaerobic or aerobic conditions, glycolysis results in production of lactate. Increasing evidence suggests that lactate serves as a multifunctional signaling molecule that develops non-metabolic activities in addition to serving as a key ...
Yumei Xie, Hongxia Hu, Maoting Liu, Tingting Zhou, Xi Cheng, Wei Huang, Ling Cao   +6 more
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OsGRF4AA compromises heat tolerance of developing pollen grains in rice

Frontiers in Plant Science, 2023
Extreme high temperature at the meiosis stage causes a severe decrease in spikelet fertility and grain yield in rice. The rice variety grain size on chromosome 2 (GS2) contains sequence variations of OsGRF4 (Oryza sativa growth-regulating factor 4 ...
Yujian Mo, Yujian Mo, Guangyan Li, Li Liu, Yingjie Zhang, Junyi Li, Meizhen Yang, Shanlan Chen, Qiaoling Lin, Guanfu Fu, Dianfeng Zheng, Dianfeng Zheng, Yu Ling, Yu Ling   +13 more
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DNA supercoiling in bacteria: state of play and challenges from a viewpoint of physics based modeling

Frontiers in Microbiology, 2023
DNA supercoiling is central to many fundamental processes of living organisms. Its average level along the chromosome and over time reflects the dynamic equilibrium of opposite activities of topoisomerases, which are required to relax mechanical stresses
Ivan Junier, Elham Ghobadpour, Elham Ghobadpour, Olivier Espeli, Ralf Everaers   +4 more
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The Elongator Subunit Elp3 Regulates Development, Stress Tolerance, Cell Cycle, and Virulence in the Entomopathogenic Fungus Beauveria bassiana

Journal of Fungi, 2022
Transcriptional activity is mediated by chromatin remodeling, which in turn is affected by post-translational modifications, including histone acetylation.
Qing Cai, Juanjuan Wang, Jiatao Xie, Daohong Jiang, Nemat O. Keyhani   +4 more
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