Results 1 to 10 of about 1,686,914 (266)

A novel chromatin-remodeling complex variant, dcPBAF, is involved in maintaining transcription in differentiated neurons

Frontiers in Cell and Developmental Biology, 2023
The Polybromo-associated BAF (BRG1- or BRM-associated factors) (PBAF) chromatin-remodeling complex is essential for transcription in mammalian cells.
Nataliya V. Soshnikova, Nataliya V. Soshnikova, Nataliya V. Soshnikova, Asya M. Azieva, Asya M. Azieva, Nataliya S. Klimenko, Alvina I. Khamidullina, Alexey V. Feoktistov, Alexey V. Feoktistov, Andrey A. Sheynov, Alexander V. Brechalov, Victor V. Tatarskiy, Sofia G. Georgieva   +12 more
doaj   +1 more source

Structural basis of copper-efflux-regulator-dependent transcription activation

iScience, 2021
Summary: The copper efflux regulator (CueR), a representative member of mercury resistance regulator (MerR) family metalloregulators, controls expression of copper homeostasis-regulating genes in bacteria.
Wei Shi, Baoyue Zhang, Yanan Jiang, Chang Liu, Wei Zhou, Ming Chen, Yang Yang, Yangbo Hu, Bin Liu   +8 more
doaj   +1 more source

The sequential phosphorylation of PHF10 subunit of the PBAF chromatin-remodeling complex determines different properties of the PHF10 isoforms

Biology Open, 2020
The mammalian PBAF subfamily of SWI/SNF chromatin remodeling complexes plays a wide role in the regulation of gene expression. PHF10 is a subunit of the signature module of PBAF, responsible for its interaction with chromatin.
Andrey A. Sheynov, Victor V. Tatarskiy, Eugene V. Tatarskiy, Elena N. Nabirochkina, Sofia G. Georgieva, Nataliya V. Soshnikova   +5 more
doaj   +1 more source

Structural visualization of transcription activated by a multidrug-sensing MerR family regulator

Nature Communications, 2021
The MerR family of transcriptional regulators, such as EcmrR, activate promoters with a structure that is suboptimal for recognition by RNA polymerase holoenzyme. Structural insights into the EcmrR-dependent transcription process elucidate the mechanisms
Yang Yang, Chang Liu, Wei Zhou, Wei Shi, Ming Chen, Baoyue Zhang, David G. Schatz, Yangbo Hu, Bin Liu   +8 more
doaj   +1 more source

Immunologic, metabolic and genetic impact of diabetes on tuberculosis susceptibility

Frontiers in Immunology, 2023
Due to the increasing prevalence of diabetes mellitus (DM) globally, the interaction between DM and major global diseases like tuberculosis (TB) is of great public health significance, with evidence of DM having about a three-fold risk for TB disease. TB
Phillip Ssekamatte, Obondo James Sande, Reinout van Crevel, Irene Andia Biraro   +3 more
doaj   +1 more source

Bacterial MerR family transcription regulators: activationby distortion

Acta Biochimica et Biophysica Sinica, 2021
Transcription factors (TFs) modulate gene expression by regulating the accessibility of promoter DNA to RNA polymerases (RNAPs) in bacteria. The MerR family TFs are a large class of bacterial proteins unique in their physiological functions and molecular
Fang Chengli, Zhang Yu
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CFIm25 regulates human stem cell function independently of its role in mRNA alternative polyadenylation

RNA Biology, 2022
It has recently been shown that CFIm25, a canonical mRNA 3’ processing factor, could play a variety of physiological roles through its molecular function in the regulation of mRNA alternative polyadenylation (APA). Here, we used CRISPR/Cas9-mediated gene
Yi Ran, Shanshan Huang, Junjie Shi, Qiumin Feng, Yanhui Deng, Andy Peng Xiang, Chengguo Yao   +6 more
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Different functions of PHF10 isoforms – subunits of the PBAF chromatin remodeling complex

Вавиловский журнал генетики и селекции, 2019
Chromatin remodelling multiprotein complexes play an important role in regulation of gene expression in embryogenesis and in the adult organism. Mutations in the subunits of the complexes are often lethal or lead to developmental defects.
A. A. Sheynov, V. V. Tatarskiy, A. M. Azieva, S. G. Georgieva, N. V. Soshnikova   +4 more
doaj   +1 more source

AHDC1/Gibbin: a master regular of chromatin structure and gene transcription [PDF]

Frontiers in Neurology
Linyi Li, Chao Zhang, Yanwen Qin
doaj   +2 more sources

LSD1 Facilitates Pro-Inflammatory Polarization of Macrophages by Repressing Catalase

Cells, 2021
The increased level of hydrogen peroxide accompanies some modes of macrophage specification and is linked to ROS-based antimicrobial activity of these phagocytes.
Maciej Sobczak, Magdalena Strachowska, Karolina Gronkowska, Iwona Karwaciak, Łukasz Pułaski, Agnieszka Robaszkiewicz   +5 more
doaj   +1 more source