Results 1 to 10 of about 124,418 (260)
Nature CommunicationsSwitch defective/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes are multi-subunit machineries that establish and maintain chromatin accessibility and gene expression by regulating chromatin structure.
Yawen Lei +11 more
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ATP-dependent chromatin remodeling in the DNA-damage response
Epigenetics & Chromatin, 2012 The integrity of DNA is continuously challenged by metabolism-derived and environmental genotoxic agents that cause a variety of DNA lesions, including base alterations and breaks.
Lans Hannes +2 more
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Human chromatin remodelers regulating HIV-1 transcription: a target for small molecule inhibitors
Epigenetics & ChromatinHIV-1 can establish a lifelong infection by incorporating its proviral DNA into the host genome. Once integrated, the virus can either remain dormant or start active transcription, a process governed by the HIV Tat protein, host transcription factors and
Yuan Ma, Chuan Li, Susana Valente
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Activation of gene expression by histone deubiquitinase OTLD1
Epigenetics, 2017 One of the main mechanisms of epigenetic control is post translational modification of histones, and one of the relatively less characterized, yet functionally important histone modifications is monoubiquitylation, which is reversed by histone ...
Ido Keren, Vitaly Citovsky
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Epigenetics, 2019 Potential functional coordination between histone deubiquitinases and histone lysine demethylases represents one of the least studied aspects of epigenetic control of transcriptional outcomes.
Ido Keren +2 more
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Protease-mediated PRC1 dissociation promotes H2AK119ub remodeling during stress responses
The EMBO JournalChromatin must remain competent for responding rapidly to stress signals. Polycomb repressive complex 1 (PRC1) contributes to chromatin compaction through mono-ubiquitylation of histone H2A at Lys119 (H2AK119ub), yet how PRC1 complexes are dissociated ...
Wei Cui +15 more
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Chromatin remodeling in plant development
The International Journal of Developmental Biology, 2009 Plant development results from specific patterns of gene expression that are tightly regulated in a spatio-temporal manner. Chromatin remodeling plays a central role in establishing these expression patterns and maintaining epigenetic transcriptional states through successive rounds of mitosis that take place within a cell lineage.
Jose A. Jarillo +7 more
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Mutation in DDM1 inhibits the homology directed repair of double strand breaks.
PLoS ONE, 2019 In all organisms, DNA damage must be repaired quickly and properly, as it can be lethal for cells. Because eukaryotic DNA is packaged into nucleosomes, the structural units of chromatin, chromatin modification is necessary during DNA damage repair and is
Seung Hee Choi +5 more
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DNA repair synthesis and histone deposition partner during homologous recombination
Molecular & Cellular Oncology, 2018 Chromatin remodeling is critical for the regulation of the DNA damage response. We highlight findings from our recent study showing that the deposition of the histone variant H3.3 by the alpha-thalassemia mental retardation X-linked protein (ATRX) and ...
Amira Elbakry +3 more
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SIRT7 and p53 interaction in embryonic development and tumorigenesis
Frontiers in Cell and Developmental Biologyp53 is a hallmark tumor suppressor due in part to its role in cell cycle progression, DNA damage repair, and cellular apoptosis; its protein activity interrelates with the Sirtuin family of proteins, major regulators of the cellular response to metabolic,
Berta N. Vazquez +18 more
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