Results 31 to 40 of about 680,917 (346)
PTEN in Chromatin Remodeling [PDF]
Cold Spring Harbor Perspectives in Medicine, 2019 The tumor suppressor phosphatase and tension homolog (PTEN) is frequently mutated in human cancers, and it functions in multiple ways to safeguard cells from tumorigenesis. In the cytoplasm, PTEN antagonizes the PI3K/AKT pathway and suppresses cellular proliferation and survival.
Jingyi, Yang, Yuxin, Yin
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Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration
Cell & Bioscience, 2023 The dynamic changes in chromatin conformation alter the organization and structure of the genome and further regulate gene transcription. Basically, the chromatin structure is controlled by reversible, enzyme-catalyzed covalent modifications to chromatin
Dongfang Jiang +4 more
doaj +1 more source
Mechanism of chromatin remodeling [PDF]
Proceedings of the National Academy of Sciences, 2010 Results from biochemical and structural studies of the RSC chromatin-remodeling complex prompt a proposal for the remodeling mechanism: RSC binding to the nucleosome releases the DNA from the histone surface and initiates DNA translocation (through one or a small number of DNA base pairs); ATP binding completes translocation, and ATP hydrolysis resets ...
Yahli, Lorch +2 more
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Knockdown of DOM/Tip60 Complex Subunits Impairs Male Meiosis of Drosophila melanogaster
Cells, 2023 ATP-dependent chromatin remodeling complexes are involved in nucleosome sliding and eviction and/or the incorporation of histone variants into chromatin to facilitate several cellular and biological processes, including DNA transcription, replication and
Yuri Prozzillo +5 more
doaj +1 more source
Chromatin Remodeling and Cancer [PDF]
Cancer Biology & Therapy, 2003 The fate of the cell relies on a delicate balance between gene expression and repression. The transcriptional control of the genome is maintained not only by transcription factors but also chromatin remodeling proteins. The purpose of the chromatin remodeling proteins is to alter the nucleosome architecture such that genes are exposed to or hidden from
Penny K, Davis, Rainer K, Brackmann
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Sodium Valproate-Induced Chromatin Remodeling
Frontiers in Cell and Developmental Biology, 2021 Valproic acid/sodium valproate (VPA), a drug originally prescribed as an anticonvulsant, has been widely reported to act on epigenetic marks by inducing histone acetylation, affecting the DNA and histone methylation status, and altering the expression of
Maria Luiza S. Mello
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Cryo-EM structure of SWI/SNF chromatin remodeling complex with nucleosome
Nature, 2020 The chromatin-remodelling complex SWI/SNF is highly conserved and has critical roles in various cellular processes, including transcription and DNA-damage repair1,2.
Yan Han +3 more
semanticscholar +1 more source
ATP-dependent chromatosome remodeling [PDF]
, 2008 Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Chioda, Mariacristina +2 more
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The Latest Twists in Chromatin Remodeling [PDF]
Biophysical Journal, 2018 In its most restrictive interpretation, the notion of chromatin remodeling refers to the action of chromatin-remodeling enzymes on nucleosomes with the aim of displacing and removing them from the chromatin fiber (the effective polymer formed by a DNA molecule and proteins).
Blossey, R., Schiessel, H.
openaire +4 more sources
Cancer Science, 2020 The SWI/SNF chromatin remodeling complex is composed of approximately 15 subunits, and approximately 20% of all cancers carry mutations in the genes encoding these subunits.
Mariko Sasaki, H. Ogiwara
semanticscholar +1 more source