Results 51 to 60 of about 199,504 (302)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Common CHD8 Genomic Targets Contrast With Model-Specific Transcriptional Impacts of CHD8 Haploinsufficiency. [PDF]

, 2018
The packaging of DNA into chromatin determines the transcriptional potential of cells and is central to eukaryotic gene regulation. Case sequencing studies have revealed mutations to proteins that regulate chromatin state, known as chromatin remodeling ...
Catta-Preta, Rinaldo, Lim, Kenneth, Nord, Alex S, Wade, A Ayanna   +3 more
core   +6 more sources

Chromatin Remodeling and Cancer [PDF]

Cancer Biology & Therapy, 2003
The fate of the cell relies on a delicate balance between gene expression and repression. The transcriptional control of the genome is maintained not only by transcription factors but also chromatin remodeling proteins. The purpose of the chromatin remodeling proteins is to alter the nucleosome architecture such that genes are exposed to or hidden from
Penny K, Davis, Rainer K, Brackmann
openaire   +2 more sources

Biophysics of Chromatin Remodeling

Annual Review of Biophysics, 2021
As primary carriers of epigenetic information and gatekeepers of genomic DNA, nucleosomes are essential for proper growth and development of all eukaryotic cells. Although they are intrinsically dynamic, nucleosomes are actively reorganized by ATP-dependent chromatin remodelers.
Ilana M, Nodelman, Gregory D, Bowman
openaire   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The bromodomain-containing protein Ibd1 links multiple chromatin related protein complexes to highly expressed genes in Tetrahymena thermophila

, 2018
Background: The chromatin remodelers of the SWI/SNF family are critical transcriptional regulators. Recognition of lysine acetylation through a bromodomain (BRD) component is key to SWI/SNF function; in most eukaryotes, this function is attributed to ...
Burtch, Alyson, Fillingham, Jeffrey, Garg, Jyoti, Gingras, Anne-Claude, Lambert, Jean-Philippe, Mudalige, Cristina Thuppu, Nabeel-Shah, Syed, Pearlman, Ronald E., Ponce, Marcelo, Saettone, Alejandro   +9 more
core   +1 more source

Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. [PDF]

, 2017
ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is frequently mutated in cancer. Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation.
Amaral, Maria Luisa, Benner, Christopher, Hargreaves, Diana C, Kelso, Timothy WR, Porter, Devin K, Shokhirev, Maxim N   +5 more
core   +1 more source

Non-mammalian model organisms in epigenetic research : an overview [PDF]

, 2020
Recent advances in sequencing technology and genome editing tools had an indisputably enormous impact on our understanding of complex biological pathways and their genetic and epigenetic regulation.
Baruah, Sri Kartik, Bossier, Peter, Norouzitallab, Parisa, Vanrompay, Daisy   +3 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Inhibition of chromatin condensation disrupts planar cell migration

Nucleus
Cell migration involves the actin cytoskeleton, and recently recognized nuclear involvement. In this study, we explore the impact of chromatin remodeling on cell migration using NIH 3T3 cells and a scratch wound assay subjected to pharmacological ...
Jack Forman, Briar Hine, Samantha Kaonis, Soham Ghosh   +3 more
doaj   +1 more source