Results 61 to 70 of about 422,700 (297)

Basis of specificity for a conserved and promiscuous chromatin remodeling protein

eLife, 2021
Eukaryotic genomes are organized dynamically through the repositioning of nucleosomes. Isw2 is an enzyme that has been previously defined as a genome-wide, nonspecific nucleosome spacing factor.
Drake A Donovan, Johnathan G Crandall, Vi N Truong, Abigail L Vaaler, Thomas B Bailey, Devin Dinwiddie, Orion GB Banks, Laura E McKnight, Jeffrey N McKnight   +8 more
doaj   +1 more source

The SIRT7-nucleolus connection in cancer: ARF enters the fray

Molecular & Cellular Oncology
The nucleolar enzyme sirtuin 7 (SIRT7) promotes cancer progression in certain malignancies, likely in part by controlling ribosome biosynthesis. Recently, we discovered that SIRT7 destabilizes the cyclin dependent kinase inhibitor 2A (CDKN2A, known as ...
Shahriar Tarighi, Poonam Kumari, Alejandro Vaquero, Thomas Braun, Alessandro Ianni   +4 more
doaj   +1 more source

Studying PAR-Dependent Chromatin Remodeling to Tackle PARPi Resistance. [PDF]

, 2021
Histone eviction and chromatin relaxation are important processes for efficient DNA repair. Poly(ADP) ribose (PAR) polymerase 1 (PARP1) is a key mediator of this process, and disruption of PARP1 activity has a direct impact on chromatin structure.
Andronikou, Christina, Rottenberg, Sven
core   +2 more sources

Molecular profiling of biliary tract cancers reveals distinct genomic landscapes between circulating and tissue tumor DNA

Experimental Hematology & Oncology
Biliary tract cancers (BTCs) are heterogeneous malignancies with dismal prognosis due to tumor aggressiveness and poor response to limited current therapeutic options.
Clémence Astier, Carine Ngo, Léo Colmet-Daage, Virginie Marty, Olivia Bawa, Claudio Nicotra, Maud Ngo-Camus, Antoine Italiano, Christophe Massard, Jean-Yves Scoazec, Cristina Smolenschi, Michel Ducreux, Antoine Hollebecque, Sophie Postel-Vinay   +13 more
doaj   +1 more source

Differential chromatin accessibility in peripheral blood mononuclear cells underlies COVID-19 disease severity prior to seroconversion

Scientific Reports, 2022
SARS-CoV-2 infection triggers profound and variable immune responses in human hosts. Chromatin remodeling has been observed in individuals severely ill or convalescing with COVID-19, but chromatin remodeling early in disease prior to anti-spike protein ...
Nicholas S. Giroux, Shengli Ding, Micah T. McClain, Thomas W. Burke, Elizabeth Petzold, Hong A. Chung, Grecia O. Rivera, Ergang Wang, Rui Xi, Shree Bose, Tomer Rotstein, Bradly P. Nicholson, Tianyi Chen, Ricardo Henao, Gregory D. Sempowski, Thomas N. Denny, Maria Iglesias De Ussel, Lisa L. Satterwhite, Emily R. Ko, Geoffrey S. Ginsburg, Bryan D. Kraft, Ephraim L. Tsalik, Xiling Shen, Christopher W. Woods   +23 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Chromatin Remodeling in VSMC Phenotype Switching During Vascular Remodeling: From Mechanism to Therapeutic Potential

Biomolecules
Vascular remodeling is a characteristic pathological feature of various vascular diseases, including atherosclerosis, restenosis following vascular injury, hypertension, and aneurysms. The phenotypic switching of vascular smooth muscle cells (VSMCs) acts
Xiaozhu Ma, Shuai Mei, Qidamugai Wuyun, Li Zhou, Hu Ding, Jiangtao Yan   +5 more
doaj   +1 more source

Engineered Chromatin Remodeling Proteins for Precise Nucleosome Positioning

Cell Reports, 2019
Summary: Regulation of chromatin structure is essential for controlling access of DNA to factors that require association with specific DNA sequences. Here we describe the development and validation of engineered chromatin remodeling proteins (E-ChRPs ...
Drake A. Donovan, Johnathan G. Crandall, Orion G.B. Banks, Zena D. Jensvold, Vi Truong, Devin Dinwiddie, Laura E. McKnight, Jeffrey N. McKnight   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Dietary polyphenols and chromatin remodeling

Critical Reviews in Food Science and Nutrition, 2017
Polyphenols are the most abundant phytochemicals in fruits, vegetables, and plant-derived beverages. Recent findings suggest that polyphenols display the ability to reverse adverse epigenetic regulation involved in pathological conditions, such as obesity, metabolic disorder, cardiovascular and neurodegenerative diseases, and various forms of cancer ...
Gian Luigi Russo, Viviana Vastolo, Marco Ciccarelli, Luigi Albano, Paolo Emidio Macchia, Paola Ungaro   +5 more
openaire   +5 more sources