Results 81 to 90 of about 199,504 (302)

Surface Roughness Gradients Reveal Topography‐Specific Mechanosensitive Responses in Human Mesenchymal Stem Cells [PDF]

, 2020
The topographic features of an implant, which mechanically regulate cell behaviors and functions, are critical for the clinical success in tissue regeneration.
Camacho, Luis Cuellar, Haag, Rainer, Hou, Yong, Nie, Chuanxiong, Wei, Qiang, Xie, Wenyan, Yu, Leixiao, Zhang, Man   +7 more
core   +1 more source

Theory of active chromatin remodeling [PDF]

Physical Review Letters, 2019
Nucleosome positioning controls the accessible regions of chromatin and plays essential roles in DNA-templated processes. ATP driven remodeling enzymes are known to be crucial for its establishment in vivo, but their non-equilibrium nature has hindered the development of a unified theoretical framework for nucleosome positioning.
Jiang, Zhongling, Zhang, Bin
openaire   +3 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization [PDF]

, 2015
The ends of eukaryotic chromosomes need to be protected from the activation of a DNA damage response that leads the cell to replicative senescence or apoptosis.
Alicata, Claudia, Cacchione, Stefano, Cicconi, Alessandro, Galati, Alessandra, Gilson, Eric, Giraud Panis, Marie Josèphe, Ingegnere, Tiziano, Micheli, Emanuela, Pusch, Miriam Caroline   +8 more
core   +3 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Replication-Coupled Nucleosome Assembly and Positioning by ATP-Dependent Chromatin-Remodeling Enzymes

Cell Reports, 2016
During DNA replication, chromatin must be disassembled and faithfully reassembled on newly synthesized genomes. The mechanisms that govern the assembly of chromatin structures following DNA replication are poorly understood.
Tejas Yadav, Iestyn Whitehouse
doaj   +1 more source

Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin [PDF]

, 2014
Actively transcribed regions of the genome are vulnerable to genomic instability. Recently, it was discovered that transcription is repressed in response to neighboring DNA double-strand breaks (DSBs).
Alex D. Herbert, Amani Ismail, Andreas Kakarougkas, Anna L. Chambers, Brownlee, Campbell, Cao, Chambers, Chou, Enriqueta Riballo, Fradet-Turcotte, Francia, Ginjala, Goodarzi, Jessica A. Downs, Julia Künzel, Khavari, Lin, Markus Löbrich, Mathas, Matsuoka, Mattiroli, Mosesso, Noon, Oum, Papamichos-Chronakis, Penny A. Jeggo, Rulten, Schaaf, Shain, Shanbhag, Shema-Yaacoby, Shibata, Stiff, Varela, Vissers, Wei   +36 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Chromatin-remodeling links metabolic signaling to gene expression

Molecular Metabolism, 2020
Background: ATP-dependent chromatin remodelers are evolutionarily conserved complexes that alter nucleosome positioning to influence many DNA-templated processes, such as replication, repair, and transcription.
Ashby J. Morrison
doaj   +1 more source