SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer
Protein and Cell, 2020 SIRT7, a sirtuin family member implicated in aging and disease, is a regulator of metabolism and stress responses. It remains elusive how human somatic stem cell populations might be impacted by SIRT7. Here, we found that SIRT7 expression declines during
Guang-Hui Liu, Moshi Song, Zehua Wang
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SIRT7 Inhibits Adipose Tissue Browning Through Deacetylation of PPARγ2 at K382 [PDF]
CellsAdipose tissue (AT) browning is an inducible cellular phenomenon that promotes lipid oxidation to increase energy expenditure, reducing adiposity. Various transcription regulators involved in the AT browning process have been reported, but their complex ...
Avizit Das +8 more
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Effects of SIRT7 Inhibition on Milk Fat Synthesis and Fatty Acid Composition in Dairy Goat Mammary Epithelial Cells [PDF]
AnimalsMilk fat, a key nutritional component of milk, not only supplies energy and immune protection for offspring but also serves as a critical quality indicator for goat milk.
Jun Li +9 more
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Frontiers in Cell and Developmental Biology, 2021 Dysregulation of protein posttranslational modification (PTM) can lead to a variety of pathological processes, such as abnormal sperm development, malignant tumorigenesis, depression, and aging process.
Ai Qing Yu +8 more
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SIRT7-mediated desuccinylation of FOXO4 suppresses ferroptosis to alleviate LPS-induced acute lung injury [PDF]
Redox BiologyProtein succinylation, an emerging post-translational modification (PTM), assumes a crucial role in the initiation and advancement of inflammatory diseases.
Kaikai Shen +12 more
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SIRT7 as a context-dependent biomarker and therapeutic target: Insights from a pan-cancer study. [PDF]
PLoS ONESIRT7 is a member of the sirtuin family and has emerged as a crucial player in cancer biology, with a multifaceted role in both tumor-promoting and tumor-suppressing activities.
K M Tanjida Islam, Shahin Mahmud
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Deacetylation of SRF catalyzed by SIRT7 protects against abdominal aortic aneurysm formation [PDF]
Experimental and Molecular MedicineAbdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease for which no effective pharmacological treatments exist. Histone deacetylases (HDACs) have emerged as critical regulators of cardiovascular pathophysiology; however, the ...
Yacheng Xiong +9 more
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Sirtuin 7 ameliorates hypertensive intestinal injury by restoring epithelial barrier integrity and gut microbiota homeostasis [PDF]
Cellular and Molecular Life SciencesHypertension is increasingly recognized as a contributor to intestinal barrier disruption and gut microbiota dysbiosis, thereby promoting systemic inflammation and end-organ damage.
Siyuan Wang +9 more
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A Double-Edged Role for SIRT7 in Cancer: Can Anti-Cancer Immunity Tip the Balance? [PDF]
PharmaceuticalsBackground/Objectives: Sirtuin 7 (SIRT7), a nuclear NAD+-dependent deacylase, plays multifaceted and sometimes opposing roles in tumorigenesis. By preserving chromatin architecture and genome integrity, SIRT7 protects against malignant transformation ...
Shahriar Tarighi +5 more
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Current Understanding of SIRT7 Function and Its Emerging Roles in the Central Nervous System [PDF]
CellsSIRT7is an NAD+-dependent deacetylase predominantly localized in the nucleolus, where it plays important roles in chromatin regulation, transcriptional control, and cellular stress response.
Yuchen Jiao +2 more
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