SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation [PDF]
Nature, 2012 Sirtuin proteins regulate diverse cellular pathways that influence genomic stability, metabolism, and ageing. SIRT7 is a mammalian sirtuin whose biochemical activity, molecular targets, and physiologic functions have been unclear. Here we show that SIRT7
Matthew F Barber +2 more
exaly +8 more sources
SIRT7: a sentinel of genome stability [PDF]
Open Biology, 2021 SIRT7 is a class III histone deacetylase that belongs to the sirtuin family. The past two decades have seen numerous breakthroughs in terms of understanding SIRT7 biological function. We now know that this enzyme is involved in diverse cellular processes,
Ming Tang, Huangqi Tang, Bo Tu
exaly +5 more sources
Discovery of SIRT7 Inhibitor as New Therapeutic Options Against Liver Cancer
Frontiers in Cell and Developmental Biology, 2022 Optimal therapeutic strategies for liver cancer patients remain challenging due to the high recurrence rate after surgical resection and chemotherapy resistance.
Chen Zhang, Yaqi Li, Zhuan Li
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Current Understanding of SIRT7 Function and Its Emerging Roles in the Central Nervous System [PDF]
CellsSIRT7is an NAD+-dependent deacetylase predominantly localized in the nucleolus, where it plays important roles in chromatin regulation, transcriptional control, and cellular stress response.
Yuchen Jiao +2 more
doaj +2 more sources
SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer
Protein and Cell, 2020 SIRT7, a sirtuin family member implicated in aging and disease, is a regulator of metabolism and stress responses. It remains elusive how human somatic stem cell populations might be impacted by SIRT7. Here, we found that SIRT7 expression declines during
Zunpeng Liu, Zeming Wu, Zehua Wang
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SIRT7 facilitates ferroptosis resistance of melanocytes via activating the SMAD3-ATF3-GPX4 signaling pathway in vitiligo [PDF]
Journal of Advanced ResearchIntroduction: Vitiligo is a hypopigmentation disorder characterized by epidermal melanocyte loss. Endogenous and exogenous oxidative stress causes the regulated cell death (RCD) of melanocytes in vitiligo.
Lili Wu +20 more
doaj +2 more sources
A Double-Edged Role for SIRT7 in Cancer: Can Anti-Cancer Immunity Tip the Balance? [PDF]
PharmaceuticalsBackground/Objectives: Sirtuin 7 (SIRT7), a nuclear NAD+-dependent deacylase, plays multifaceted and sometimes opposing roles in tumorigenesis. By preserving chromatin architecture and genome integrity, SIRT7 protects against malignant transformation ...
Shahriar Tarighi +5 more
doaj +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Dysregulation of protein posttranslational modification (PTM) can lead to a variety of pathological processes, such as abnormal sperm development, malignant tumorigenesis, depression, and aging process.
Ai Qing Yu +8 more
exaly +3 more sources
SIRT7 drives energy metabolic shifts in endometriosis via interaction with TUFM and Rhoa/Rock/Akt pathway activation [PDF]
Cellular and Molecular Life SciencesPurpose Endometriosis is characterized by the ectopic growth of endometrial-like tissue outside the uterus and altered energy metabolism, but the specific mechanisms involved remain unclear. This study aimed to investigate the impact of Sirtuins7 (SIRT7)
Huaying Zhang +8 more
doaj +2 more sources
SIRT7 ameliorates Th17/Treg imbalance by desuccinylation of STAT3 to improve immune thrombocytopenia [PDF]
Clinical & Translational ImmunologyObjectives The imbalance of Th17/Treg cells represents a key pathogenic mechanism in immune thrombocytopenia (ITP); however, the underlying regulatory mechanisms remain poorly understood.
Jiao Ge +3 more
doaj +2 more sources