Results 21 to 30 of about 7,699 (204)
Biomedicines, 2022 Accumulating evidence has shown that sirtuin 7 (SIRT7), a mediator of various cellular activities, plays an important role in the pathogenesis of various immune-mediated inflammatory disorders.
Sanghyun Kim +13 more
doaj +1 more source
The SIRT7-nucleolus connection in cancer: ARF enters the fray
Molecular & Cellular OncologyThe nucleolar enzyme sirtuin 7 (SIRT7) promotes cancer progression in certain malignancies, likely in part by controlling ribosome biosynthesis. Recently, we discovered that SIRT7 destabilizes the cyclin dependent kinase inhibitor 2A (CDKN2A, known as ...
Shahriar Tarighi +4 more
doaj +3 more sources
Frontiers in Immunology, 2021 The host immune system plays a pivotal role in the containment of Mycobacterium tuberculosis (Mtb) infection, and host-directed therapy (HDT) is emerging as an effective strategy to treat tuberculosis (TB), especially drug-resistant TB.
Su Zhang +9 more
doaj +1 more source
Journal of Translational Medicine, 2023 Background Sirtuin 7 (SIRT7) is an oncogene that promotes tumor progression in various malignancies, however, its role and regulatory mechanism in cervical squamous cell carcinoma (CSCC) is unknown. Herein, we attempted to investigate the functional role
Juanpeng Yu +3 more
doaj +1 more source
Effects of niacin restriction on sirtuin and PARP responses to photodamage in human skin. [PDF]
, 2012 Sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs), NAD(+)-dependent enzymes, link cellular energy status with responses to environmental stresses.
Benavente, Claudia A +2 more
core +11 more sources
HIV-1 Vpr activates host CRL4-DCAF1 E3 ligase to degrade histone deacetylase SIRT7
Virology Journal, 2021 Background Vpr is a virion-associated protein that is encoded by lentiviruses and serves to counteract intrinsic immunity factors that restrict infection.
Xiaohong Zhou +3 more
doaj +1 more source
Cell Death & Differentiation, 2022 AbstractPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and its dismal prognosis indicates the urgent need to elucidate the potential oncogenic mechanisms. SIRT7 is a classic NAD+-dependent deacetylase that stabilizes the transformed state of cancer cells. However, its functional roles in PDAC are still unclear. Here, we found
Xiaoman He +8 more
openaire +2 more sources
The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate
Molecular & Cellular Oncology, 2021 Release of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization of the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to the ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent p53
Poonam Kumari +3 more
doaj +1 more source
Sirt7 inhibits Sirt1-mediated activation of Suv39h1 [PDF]
Cell Cycle, 2018 Sirtuins regulate a variety of cellular processes through protein deacetylation. The best-known member of mammalian sirtuin family, Sirt1, plays important roles in the maintenance of cellular homeostasis by regulating cell metabolism, differentiation and stress responses, among others.
Poonam Kumari +5 more
openaire +3 more sources
Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding [PDF]
, 2016 Funding: The Scottish Government's Rural and Environment Science and Analytical Services Division.Peer ...
Drew, Janice E. +3 more
core +1 more source