Results 21 to 30 of about 6,075 (158)

Protocol for high-throughput screening of SIRT7 inhibitors using fluorescent peptide technology

STAR Protocols
Summary: Fluorescent peptides combine the polypeptides with fluorescent groups organically to facilitate the measurement of enzyme activity. Here, we present a protocol to evaluate Sirtuin 7 (SIRT7) enzymatic activity by analyzing changes in luminescent ...
Tian-Shu Kang, Xiaopeng Lu, Jinke Gu, Yuan Tian, Wei-Guo Zhu   +4 more
doaj   +2 more sources

Sirtuin 7 Inhibitor Attenuates Colonic Mucosal Immune Activation in Mice—Potential Therapeutic Target in Inflammatory Bowel Disease

Biomedicines, 2022
Accumulating evidence has shown that sirtuin 7 (SIRT7), a mediator of various cellular activities, plays an important role in the pathogenesis of various immune-mediated inflammatory disorders.
Sanghyun Kim, Junhyoung Byun, Semyung Jung, Byoungjae Kim, Kangwon Lee, Hanjo Jeon, Jaemin Lee, Hyuksoon Choi, Eunsun Kim, Yoontae Jeen, Hongsik Lee, Hoonjai Chun, Bora Keum, Taehoon Kim   +13 more
doaj   +1 more source

Discovery of SIRT7 Inhibitor as New Therapeutic Options Against Liver Cancer

Frontiers in Cell and Developmental Biology, 2022
Optimal therapeutic strategies for liver cancer patients remain challenging due to the high recurrence rate after surgical resection and chemotherapy resistance.
Chen Zhang, Yaqi Li, Bohao Liu, Chao Ning, Yimin Li, Ying Wang, Zhuan Li   +6 more
doaj   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction [PDF]

Advanced science
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Meng N, Zhou J, Guo X, Hong T, Li X, Wei X, Zhang C, Zhang X, Liu S, Zhang Y, Yao L, Huang L, Gu W.   +12 more
europepmc   +2 more sources

Sirtuin 7 Regulates Nitric Oxide Production and Apoptosis to Promote Mycobacterial Clearance in Macrophages

Frontiers in Immunology, 2021
The host immune system plays a pivotal role in the containment of Mycobacterium tuberculosis (Mtb) infection, and host-directed therapy (HDT) is emerging as an effective strategy to treat tuberculosis (TB), especially drug-resistant TB.
Su Zhang, Yaya Liu, Xuefeng Zhou, Min Ou, Guohui Xiao, Fang Li, Zhongyuan Wang, Zhaoqin Wang, Lei Liu, Guoliang Zhang   +9 more
doaj   +1 more source

Correction to "Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression". [PDF]

Adv Sci (Weinh)
Advanced Science, Volume 13, Issue 52, 18 September 2026.
europepmc   +2 more sources

USP39 interacts with SIRT7 to promote cervical squamous cell carcinoma by modulating autophagy and oxidative stress via FOXM1

Journal of Translational Medicine, 2023
Background Sirtuin 7 (SIRT7) is an oncogene that promotes tumor progression in various malignancies, however, its role and regulatory mechanism in cervical squamous cell carcinoma (CSCC) is unknown. Herein, we attempted to investigate the functional role
Juanpeng Yu, Shuai Yuan, Jinglin Song, Shengsheng Yu   +3 more
doaj   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets. [PDF]

MedComm (2020)
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Wang JY, Jiang FL, Zhang FY, Huang DH, Li XY, Gao S, You H, Wu QJ, Chen HH, Gong TT.   +9 more
europepmc   +2 more sources

SIRT7-induced decrotonylation

, 2021
LC-MS data for SIRT7-induced ...
wang, Z (via Mendeley Data)
core   +1 more source

A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function [PDF]

, 2014
Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis.
Lee J. U., Perino, Alessia, Hottiger, Michael O., Jo Y. S., Auwerx, Johan, Zeviani M., Lo Sasso G., Zhang, Hongbo, Zhang H., Ryu D., Hottiger M. O., Zeviani, Massimo, Schoonjans, Kristina, Stein, Sokrates, Romand R., Schoonjans K., Hottiger, Michael O, Romand, Raymond, Perino A., Ryu, Dongryeol, Jo, Young Suk, Lo Sasso, Giuseppe, Stein S., Auwerx J., Lee, Jung Uee   +24 more
core   +2 more sources