Results 31 to 40 of about 6,075 (158)

The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate

Molecular & Cellular Oncology, 2021
Release of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization of the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to the ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent p53
Poonam Kumari, Shahriar Tarighi, Thomas Braun, Alessandro Ianni   +3 more
doaj   +1 more source

HIV-1 Vpr activates host CRL4-DCAF1 E3 ligase to degrade histone deacetylase SIRT7

Virology Journal, 2021
Background Vpr is a virion-associated protein that is encoded by lentiviruses and serves to counteract intrinsic immunity factors that restrict infection.
Xiaohong Zhou, Christina Monnie, Maria DeLucia, Jinwoo Ahn   +3 more
doaj   +1 more source

Bioinformatic analysis of SIRT7 sequence and structure

, 2022
Sirtuins are highly conserved proteins that perform very important functions in different cellular processes. Notably, SIRT7 is the least studied human sirtuin, but it is known to be involved in a wide variety of processes in both health and disease.
Lagunas-Rangel, Francisco Alejandro,, Francisco Alejandro Lagunas-Rangel, Lagunas-Rangel, Francisco Alejandro, Francisco Alejandro Lagunas-Rangel (13849122)   +3 more
core   +1 more source

SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1 [PDF]

, 2020
Sirtuins are key players in the response to oxidative, metabolic and genotoxic stress, and are involved in genome stability, metabolic homeostasis and aging.
Vaquero, A., Thackray, Joshua K, Thackray, Joshua K., Sabidó, Eduard, Serrano, L., Thackray, J., Buschbeck, Marcus, Olivella, Mireia, Hurtado-Bages, S., Sabido, E., De La Torre Gómez, Gisela Carolina, Simonet, Nicolas G.., Hurtado-Bagès, Sarah, 1990-, Esteller, Manel, Vazquez, B., Simonet, N., Sabidó Aguadé, Eduard, 1981-, Morales-Sanfrutos, J., Vazquez Prat, Berta Nieves, Esteller, M., Serrano, Lourdes, Olivella, M., Torre, Carolina de la, Tischfield, J., Simonet, Nicolás G., Braun, Thomas, Espinosa-Alcantud, M., Hurtado-Bagès, Sarah., Sabidó Aguadé, Eduard, Ianni, A., Torre Gómez, Carolina de la, Braun, T., Vazquez, Berta N., Ianni, Alessandro, Morales Sanfrutos, Julia, Tischfield, Jay, Espinosa Alcantud, Maria, Vaquero, Alejandro, Universitat Autònoma de Barcelona, De La Torre, C., Espinosa-Alcantud, María Dolores, Buschbeck, M.   +41 more
core   +1 more source

Sirt7 Deficiency Attenuates Neointimal Formation Following Vascular Injury by Modulating Vascular Smooth Muscle Cell Proliferation

, 2021
Background: Sirt7 is a recently identified sirtuin and has important roles in various pathological conditions, including cancer progression and metabolic disorders.
Izumiya, Y., Bober, E., Yamamoto, E., Yoshizawa, T., Kim-Mitsuyama, S., Araki, S., Yamamura, S., Braun, T., Yamagata, K., Sata, M., Tsujita, K., Ishida, T., Hanatani, S., Arima, Y., Onoue, Y., Senokuchi, T., Kaikita, K., Nakamura, T., Kimura, Y., Nakagata, N.   +19 more
core   +2 more sources

SIRT7 suppresses the epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis by promoting SMAD4 deacetylation

Journal of Experimental & Clinical Cancer Research, 2018
Background Oral squamous cell carcinoma (OSCC) is one of the most common malignancies and has a poor prognosis. The epithelial-to-mesenchymal transition (EMT) is crucial for increasing the metastasis of OSCC.
Wenlu Li, Dandan Zhu, Shuaihua Qin
doaj   +1 more source

SIRT7 in the aging process

, 2022
Aging is the result of the accumulation of a wide variety of molecular and cellular damage over time. This has been associated with a number of features termed hallmarks of aging, including genomic instability, loss of proteostasis, telomere attrition ...
Lagunas-Rangel, Francisco Alejandro,, Lagunas-Rangel, Francisco Alejandro   +1 more
core   +1 more source

SIRT7 is a Prognostic Biomarker in Kidney Renal Clear Cell Carcinoma That is Correlated with Immune Cell Infiltration

International Journal of General Medicine, 2022
Wei Zhang,1 Yue Qian,1 Xue Jin,2 Yixian Wang,1 Lili Mu,1 Zhixia Jiang2 1Department of Pathogen Biology, Guizhou Nursing Vocational College, Guiyang, People’s Republic of China; 2Guizhou Nursing Vocational College, Guiyang, People’s Republic of ...
Zhang W, Qian Y, Jin X, Wang Y, Mu L, Jiang Z   +5 more
doaj  

SIRT7 Links H3K18 Deacetylation to Maintenance of Oncogenic Transformation [PDF]

, 2012
Sirtuin proteins regulate diverse cellular pathways that influence genomic stability, metabolism, and ageing. SIRT7 is a mammalian sirtuin whose biochemical activity, molecular targets, and physiologic functions have been unclear. Here we show that SIRT7
Chua, Katrin F., Garcia, Benjamin A., Gozani, Or, Li, Wei, Struhl, Kevin, Kioi, Mitomu, Tennen, Ruth I., Matthew F. Barber, Chen, Kaifu, Xi, Yuanxin, Or Gozani, Barber, Matthew F., Yuanxin Xi, Kevin Struhl, Nicolas L. Young, Luisa Tasselli, Wei Li, Mitomu Kioi, Benjamin A. Garcia, Eriko Michishita-kioi, Michishita-Kioi, Eriko, Kaifu Chen, F. Chua, Nicolas L, Ruth I. Tennen, Zarmik Moqtaderi, Moqtaderi, Zarmik, Katrin F. Chua, Paredes, Silvana, Tasselli, Luisa, Young, Nicolas L., Silvana Paredes   +31 more
core   +1 more source

SIRT7 Facilitates CENP-A Nucleosome Assembly and Suppresses Intestinal Tumorigenesis

iScience, 2020
Summary: SIRT7 is a member of the mammalian sirtuins and functions as an NAD+-dependent deacylase. Here we show that SIRT7 deficiency leads to a lowered histone acetyltransferase 1 (HAT1) activity and therefore decreased histone H4K5 and H4K12 ...
Xiyang Liu, Chengling Li, Qing Li, Hung-Chun Chang, Yun-Chi Tang   +4 more
doaj   +1 more source