The current progress of histone deacetylase SIRT7 [PDF]
SCIENTIA SINICA Vitae, 2020 SIRT7, a member of the mammalian Sirtuins family, is a highly conserved NAD+ dependent protein deacetylase, which regulates the acetylation level of various proteins in cells, thus regulating many important cellular processes such as protein synthesis, metabolism, cell stress, inflammation, aging and tumors.
JunSi ZHAN +4 more
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Cellular and Molecular Life Sciences, 2022 AbstractAging is the result of the accumulation of a wide variety of molecular and cellular damage over time. This has been associated with a number of features termed hallmarks of aging, including genomic instability, loss of proteostasis, telomere attrition, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell ...
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The effects of graded levels of calorie restriction : XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome [PDF]
, 2017 We would like to acknowledge the BSU staff for their invaluable help with caring for the animals.Peer reviewedPublisher ...
Chen, Luonan +10 more
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Segmental aging underlies the development of a Parkinson phenotype in the AS/AGU rat [PDF]
, 2016 There is a paucity of information on the molecular biology of aging processes in the brain. We have used biomarkers of aging (SA β-Gal, p16Ink4a, Sirt5, Sirt6, and Sirt7) to demonstrate the presence of an accelerated aging phenotype across different ...
Khojah, Sohair M. +3 more
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Journal of Experimental & Clinical Cancer Research, 2018 Background Oral squamous cell carcinoma (OSCC) is one of the most common malignancies and has a poor prognosis. The epithelial-to-mesenchymal transition (EMT) is crucial for increasing the metastasis of OSCC.
Wenlu Li, Dandan Zhu, Shuaihua Qin
doaj +1 more source
Sirtuin functions and modulation: from chemistry to the clinic [PDF]
, 2016 Sirtuins are NAD+ -dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell ...
Altucci, Lucia +9 more
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Glycogen Synthase Kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells [PDF]
, 2014 Nuclear myosin 1c (NM1) mediates RNA polymerase I (pol I) transcription activation and cell cycle progression by facilitating PCAF-mediated H3K9 acetylation, but the molecular mechanism by which NM1 is regulated remains unclear.
A Cole +58 more
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SIRT7 Is an RNA-Activated Protein Lysine Deacylase [PDF]
ACS Chemical Biology, 2016 Mammalian SIRT7 is a member of the sirtuin family that regulates multiple biological processes including genome stability, metabolic pathways, stress responses, and tumorigenesis. SIRT7 has been shown to be important for ribosome biogenesis and transcriptional regulation.
Zhen Tong +8 more
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Sirtuins 1–7 expression in human adipose-derived stem cells from subcutaneous and visceral fat depots: influence of obesity and hypoxia [PDF]
, 2016 The sirtuin family comprises seven NAD+-dependent deacetylases which control the overall health of organisms through the regulation of pleiotropic metabolic pathways.
Di Rocco, Giuliana +5 more
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A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function [PDF]
Cell Metabolism, 2014 Mitochondrial activity is controlled by proteins encoded by both nuclear and mitochondrial DNA. Here, we identify Sirt7 as a crucial regulator of mitochondrial homeostasis. Sirt7 deficiency in mice induces multisystemic mitochondrial dysfunction, which is reflected by increased blood lactate levels, reduced exercise performance, cardiac dysfunction ...
Ryu Dongryeol +13 more
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