Results 41 to 50 of about 6,075 (158)

Advances in Cellular Characterization of the Sirtuin Isoform, SIRT7 [PDF]

, 2018
SIRT7 is one of seven mammalian sirtuins that functions as an NAD+-dependent histone/protein deacetylase. SIRT7 is the least well-known member of the sirtuin family, but recent efforts have identified its involvement in various cellular processes, such ...
Wei-Guo Zhu, Kathy S. Zhu, Haiying Wang, Yinglu Li, Di Wu   +4 more
core   +1 more source

SIRT7 depletion inhibits cell proliferation and androgen-induced autophagy by suppressing the AR signaling in prostate cancer

Journal of Experimental & Clinical Cancer Research, 2020
Background Sirtuin-7 (SIRT7) is associated with the maintenance of tumorigenesis. However, its functional roles and oncogenic mechanisms in prostate cancer (PCa) are poorly understood.
Mao Ding, Chen-Yi Jiang, Yu Zhang, Jing Zhao, Bang-Min Han, Shu-Jie Xia   +5 more
doaj   +1 more source

SIRT7 Is a Prognostic Biomarker Associated With Immune Infiltration in Luminal Breast Cancer

Frontiers in Oncology, 2020
Background: Sirtuin 7 (SIRT7), a protein-coding gene whose abnormal expression and function are associated with carcinogenesis. However, the prognosis of SIRT7 in different breast cancer subtypes and its correlation with tumor-infiltrating lymphocytes ...
Qin Huo, Zhenwei Li, Lixin Cheng, Fan Yang, Ni Xie   +4 more
doaj   +1 more source

SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation

Signal Transduction and Targeted Therapy, 2023
Melanoma is the most lethal type of skin cancer, originating from the malignant transformation of melanocyte. While the development of targeted therapy and immunotherapy has gained revolutionary advances in potentiating the therapeutic effect, the ...
Xiuli Yi, Huina Wang, Yuqi Yang, Hao Wang, Hengxiang Zhang, Sen Guo, Jianru Chen, Juan Du, Yangzi Tian, Jingjing Ma, Baolu Zhang, Lili Wu, Qiong Shi, Tianwen Gao, Weinan Guo, Chunying Li   +15 more
doaj   +1 more source

SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis

, 2017
Distant metastasis is the main cause of breast cancer-related death; however, effective therapeutic strategies targeting metastasis are still scarce. This is largely attributable to the spatiotemporal intratumor heterogeneity during metastasis.
Wei-Guo Zhu, Minxian Qian, Zuojun Liu, Mingyan Zhou, Xinyue Cao, Xiaolong Tang, Qingyang Xu, Baohua Liu, Fanbiao Meng, Lei Shi, Ni Xie   +10 more
core   +1 more source

SIRT7, H3K18ac, and ELK4 Immunohistochemical Expression in Hepatocellular Carcinoma [PDF]

, 2016
Background SIRT7 is one of the histone deacetylases and is NAD-dependent. It forms a complex with ETS-like transcription factor 4 (ELK4), which deacetylates H3K18ac and works as a transcriptional suppressor.
Baek-hui Kim, Han Gyeom Kim, Hyeyoon Chang, Hye Seung Lee, Wonkyung Jung, Jin Hyuk Choi, Aeree Kim, Eunjung Lee   +7 more
core   +1 more source

RETRACTED ARTICLE: Sirt7 promotes gastric cancer growth and inhibits apoptosis by epigenetically inhibiting miR-34a

Scientific Reports, 2015
Gastric cancer is the fourth most common cancer worldwide, with a low 5-year survival rate. Epigenetic modification plays pivotal roles in gastric cancer development.
Shun Zhang, Ping Chen, Zuoan Huang, Xiaorong Hu, Mengting Chen, Shanshan Hu, Yixin Hu, Ting Cai   +7 more
doaj   +1 more source

SIRT7 Is an RNA-Activated Protein Lysine Deacylase

, 2016
Mammalian SIRT7 is a member of the sirtuin family that regulates multiple biological processes including genome stability, metabolic pathways, stress responses, and tumorigenesis.
Tong, Z, Hao, Q, David D. Kim (3595325), Jennifer K. Grenier (3595322), Lin, HN, Wang, Y, Sushabhan Sadhukhan (1330749), Yi Wang (32470), Quan Hao (67204), Zhen Tong (1485457), Ji Cao (237887), Sadhukhan, S, Grenier, JK, Hening Lin (1306563), Wang, M, Kim, DD, Cao, J, Miao Wang (248377)   +17 more
core   +1 more source

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Mechanism of desuccinylation of G6PD mediated by SIRT7 to promote vitiligo disease progression

Immunity, Inflammation and Disease
Background Sirtuin 7 (SIRT7) is pivotal in diverse diseases progression. Importantly, SIRT7 is associated with melanin production. However, whether SIRT7 regulates vitiligo is unclear.
Yiyun Yang, Haidong Long, Lan Long, Bin Guo   +3 more
doaj   +1 more source