Results 41 to 50 of about 7,699 (204)
The modulation of sirtuins and apoptotic proteins in rats after exhaustive exercise [PDF]
, 2012 A large body of evidence shows that a single bout of strenuous exercise induces oxidative stress in circu- lating human lymphocytes leading to lipid peroxide- tion, DNA damage, mitochondrial perturbations, and protein oxidation. In a training experiment,
Gambacurta, A +6 more
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Bioinformatic analysis of SIRT7 sequence and structure
Journal of Biomolecular Structure and Dynamics, 2022 Sirtuins are highly conserved proteins that perform very important functions in different cellular processes. Notably, SIRT7 is the least studied human sirtuin, but it is known to be involved in a wide variety of processes in both health and disease.
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International Journal of General Medicine, 2022 Wei Zhang,1 Yue Qian,1 Xue Jin,2 Yixian Wang,1 Lili Mu,1 Zhixia Jiang2 1Department of Pathogen Biology, Guizhou Nursing Vocational College, Guiyang, People’s Republic of China; 2Guizhou Nursing Vocational College, Guiyang, People’s Republic of ...
Zhang W +5 more
doaj
Role of SIRT7 in hepatic lipid metabolism [PDF]
Diabetology International, 2015 Sirtuins are evolutionarily conserved enzymes that regulate a wide variety of biological processes, such as aging, genomic stability, tumorigenesis, and metabolism [1]. To date, seven sirtuins have been identified in mammals (SIRT1–SIRT7), which share a highly conserved NADbinding and catalytic core domain, but have distinct flanking Nand C-terminal ...
Kazuya Yamagata +3 more
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Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. [PDF]
, 2017 The expansion of CD8+CD28- T cells, a population of terminally differentiated memory T cells, is one of the most consistent immunological changes in humans during aging.
Fei, Mingjian +11 more
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SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability [PDF]
International Journal of Molecular Sciences, 2020 Serine-threonine kinase receptor-associated protein (STRAP) functions as a regulator of both TGF-β and p53 signaling that participates in the regulation of cell proliferation and cell death in response to various stresses. Here, we demonstrate that STRAP acetylation plays an important role in p53-mediated cell cycle arrest and apoptosis.
Miao Yu +11 more
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SIRTain regulators of premature senescence and accelerated aging. [PDF]
, 2015 The sirtuin proteins constitute class III histone deacetylases (HDACs). These evolutionarily conserved NAD(+)-dependent enzymes form an important component in a variety of cellular and biological processes with highly divergent as well as convergent ...
Ghosh, S, Zhou, Z
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Transcriptome profiling of sheep granulosa cells and oocytes during early follicular development obtained by Laser Capture Microdissection [PDF]
, 2011 Background Successful achievement of early folliculogenesis is crucial for female reproductive function. The process is finely regulated by cell-cell interactions and by the coordinated expression of genes in both the oocyte and in granulosa cells ...
Agnes Bonnet +11 more
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Differential expression of sirtuins in the aging rat brain [PDF]
, 2015 Although there are seven mammalian sirtuins (SIRT1-7), little is known about their expression in the aging brain. To characterize the change(s) in mRNA and protein expression of SIRT1-7 and their associated proteins in the brain of "physiologically" aged
Anne Poljak +8 more
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Journal of Experimental & Clinical Cancer Research, 2020 Background Sirtuin-7 (SIRT7) is associated with the maintenance of tumorigenesis. However, its functional roles and oncogenic mechanisms in prostate cancer (PCa) are poorly understood.
Mao Ding +5 more
doaj +1 more source