Results 61 to 70 of about 6,075 (158)

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

Enhanced expression and phosphorylation of Sirt7 activates smad2 and ERK signaling and promotes the cardiac fibrosis differentiation upon angiotensin-II stimulation.

PLoS ONE, 2017
Cardiac fibroblasts (CFs) phenotypic conversion to myofibroblasts (MFs) represents a crucial event in cardiac fibrosis that leads to impaired cardiac function. However, regulation of this phenotypic transformation remains unclear.
Haichen Wang, Shengwu Liu, Shengqiang Liu, Wei Wei, Xiaolong Zhou, Fang Lin, Juanjuan Wang, Jinye Chen, Guodong Zhang, Yongbing Pang   +9 more
doaj   +1 more source

SIRT7 regulates hepatocellular carcinoma response to therapy by altering the p53-dependent cell death pathway

Journal of Experimental & Clinical Cancer Research, 2019
Background Optimal therapeutic strategies for hepatocellular carcinoma (HCC) patients are still challenging due to the high recurrence rate after surgical resection and chemotherapy resistance.
Jie Zhao, Ann Wozniak, Abby Adams, Josiah Cox, Anusha Vittal, Jordan Voss, Brian Bridges, Steven A. Weinman, Zhuan Li   +8 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Pyrazolyl Thioureas (PTUs) as SIRT1 and SIRT2 Inhibitors

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Pyrazolyl thioureas were designed and synthesized as sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) inhibitors. 6a (IC50 (SIRT1) = 5.3 µM; IC50 (SIRT2) = 2.2 µM) and 7f (IC50 (SIRT1) = 12.4 µM; IC50 (SIRT2) = 13.6 µM) showed micromolar inhibition on target enzymes and HepG2‐based assays confirmed a SIRT2‐mediated effect on tubulin acetylation. Docking studies
Matteo Lusardi, Cecilia Astigiano, Deianira Bellitto, Matteo Raineri, Giorgia Guccione, Annalisa Salis, Elena Cichero, Chiara Brullo, Marco Ponassi, Santina Bruzzone, Andrea Spallarossa   +10 more
wiley   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

The SIRT7-nucleolus connection in cancer: ARF enters the fray [PDF]

The nucleolar enzyme sirtuin 7 (SIRT7) promotes cancer progression in certain malignancies, likely in part by controlling ribosome biosynthesis. Recently, we discovered that SIRT7 destabilizes the cyclin dependent kinase inhibitor 2A (CDKN2A, known as ...
Thomas Braun, Alejandro Vaquero, Alessandro Ianni, Braun, T., Tarighi, S., Vaquero, Alejandro, Ianni, Alessandro, Universitat Autònoma de Barcelona, Kumari, P., Poonam Kumari, Shahriar Tarighi   +10 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, Volume 7, Issue 3, Page 99-108, September 2026.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

SIRT1 Silences L1 Retrotransposons by Stabilizing Heterochromatin‐Modifying Complexes

Aging Cell, Volume 25, Issue 9, September 2026.
SIRT1 binds the LINE‐1 5′‐UTR and recruits the heterochromatin modifiers Lamin B1 and KAP1 to maintain H3K9me3 levels, thereby suppressing LINE‐1 retrotransposition. SIRT1 deficiency enhances LINE‐1 transcription, leading to upregulation of senescence‐associated secretory phenotype factors, activation of the cGAS‐STING pathway, and consequent cellular ...
Xiaona Wang, Tianbo Li, Huanyin Tang, Meng Xiao Liu, Qinghua Peng, Xiao Huang, Zhiyong Mao, Ying Jiang, Anke Geng   +8 more
wiley   +1 more source

SIRT7 remodels the cytoskeleton via RAC1 to enhance host resistance to Mycobacterium tuberculosis

mBio
Phagocytosis of Mycobacterium tuberculosis (Mtb) followed by its integration into the matured lysosome is critical in the host defense against tuberculosis. How Mtb escapes this immune attack remains elusive. In this study, we unveiled a novel regulatory
Fuxiang Li, Ximeng Zhang, Jinjin Xu, Yue Zhang, Guo Li, Xirui Yang, Guofang Deng, Youchao Dai, Baohua Liu, Christian Kosan, Xinchun Chen, Yi Cai   +11 more
doaj   +1 more source

Skin Aging: From Molecular Mechanisms to Therapeutic and Technological Innovations

Journal of Cellular and Molecular Medicine, Volume 30, Issue 18, September 2026.
ABSTRACT Aging is a complex, pervasive biological process that causes irreversible declines in function across organ systems. The skin, the body's largest organ, interfaces directly with the external environment and undergoes aging driven by intrinsic (chronological) and extrinsic (environmental) factors, which result in functional deterioration and ...
Sanyin Chen, Yi Yang, Xiaohua Pan, Yu Pan, Sa Cai   +4 more
wiley   +1 more source