Results 81 to 90 of about 6,075 (158)

Structural basis of SIRT7 nucleosome engagement and substrate specificity

Chromatin-modifying enzymes target distinct residues within histones to finetune gene expression profiles. SIRT7 is an NAD+-dependent deacylase often deregulated in cancer, which deacetylates either H3 lysine 36 (H3K36) or H3K18 with high specificity ...
Ekundayo, Babatunde E., Foteva, Polina N., Fierz, Beat, Calvino-Sanles, Esther, Moreno-Yruela, Carlos, Ekundayo, B.E., Ni, D., Stahlberg, Henning, Stahlberg, H., Fierz, B., Calvino-Sanles, E., Ni, Dongchun, Moreno-Yruela, C., Foteva, P.N.   +13 more
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Loss of Sirtuin 7 impairs cell motility and proliferation and enhances S-phase cell arrest after 5-fluorouracil treatment in head and neck cancer

Scientific Reports
Sirtuin 7 (SIRT7), a member of the sirtuin family of NAD+-dependent deacetylases, plays a vital role in cancer, exhibiting context-dependent functions across various malignancies.
Marta Halasa, Syeda Afshan, Anna Wawruszak, Agata Borkowska, Klaudia Brodaczewska, Alicja Przybyszewska-Podstawka, Joanna Kalafut, Marzena Baran, Adolfo Rivero-Müller, Andrzej Stepulak, Matthias Nees   +10 more
doaj   +1 more source

SIRT7 Prevents Intervertebral Disc Degeneration by Inhibiting the NF-κB Pathway

Frontiers in Bioscience-Landmark
Background: Nucleus pulposus (NP) cell apoptosis and extracellular matrix (ECM) degradation constitute the two major pathological hallmarks of intervertebral disc degeneration (IVDD).
Dongxin Wang, Zhili Yang, Lei Li, Guangzhi Zhang, Zhenyu Cao, Tianyue Liu, Xuewen Kang   +6 more
doaj   +1 more source

Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer [PDF]

, 2017
5-Fluorouracil (5-FU) combined with radiotherapy is a common treatment strategy to treat human cancers, but the underlying mechanisms of this combination treatment remain unclear.
Liu, Baohua, Yongcan Chen, Hui Wang, Chen, Yongcan, Tang, Ming, Baohua Liu, Luo, Jianyuan, Gu, Jin, Wei-Guo Zhu, Wang, Haiying, Lu Jiang, Lu, Xiaopeng, Du, Changzheng, Linlin Cao, Ming Tang, Tu, Bo, Zhu, Wei-Guo, Cao, Ziyang, Ziyang Cao, Jin Gu, Zhang, Chaohua, Xingzhi Xu, Bo Tu, Xiaopeng Lu, Cao, Linlin, Haiying Wang, Wang, Hui, Wang, Lina, Chaohua Zhang, Xu, Xingzhi, Zhiming Li, Jiadong Wang, Jiang, Lu, Tianyun Hou, Li, Zhiming, Hou, Tianyun, Changzheng Du, Yinglu Li, Jianyuan Luo, Li, Yinglu, Lina Wang, Wang, Jiadong   +41 more
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Analysis of Metabolic Characteristics of SIRT7 Low Expression Glioma Cell Line Using NMR-Based Metabonomics

Chinese Journal of Magnetic Resonance, 2019
Tumor is a metabolic disease. The effect of oncogene expression on the metabolism of cancer cells is one of the hotspots in cancer research. In this study, 1H NMR-based metabonomics analysis was used to explore the metabolic characteristics of glioma ...
SHAO Wei, LIN Qing-yuan, YANG Wen-sheng, HUANG Cai-hua, LIN Dong-hai   +4 more
doaj   +1 more source

Comparative interactomes of SIRT6 and SIRT7: Implication of functional links to aging.

, 2014
Sirtuins are NAD(+) -dependent deacetylases that regulate a range of cellular processes. Although diverse functions of sirtuins have been proposed, those functions of SIRT6 and SIRT7 that are mediated by their interacting proteins ...
Lee, N, Park, SM, Kim, ES, Kwon, JH, Shin, J, Choi, KY, Kim, DK, Park, SJ, Moon, YH, Wang, HJ, Gho, YS   +10 more
core   +1 more source

SIRT7 Controls Hepatic Lipid Metabolism by Regulating the Ubiquitin-Proteasome Pathway [PDF]

, 2014
SummarySirtuins (SIRT1-7) have attracted considerable attention as regulators of metabolism over the past decade. However, the physiological functions and molecular mechanisms of SIRT7 are poorly understood.
Senokuchi, Takafumi, Takeya, Motohiro, Ando, Yukio, Braun, Thomas, Smolka, Christian, Tomizawa, Kazuhito, Karim, Md. Fazlul, Kadomatsu, Tsuyoshi, Oike, Yuichi, Sato, Yoshifumi, Miyata, Keishi, Yoshizawa, Tatsuya, Uchimura, Kohei, Akaike, Takaaki, Yamagata, Kazuya, Tian, Zhe, Go, Chisa, Sawa, Tomohiro, Bober, Eva, Fukuda, Takaichi, Tasaki, Masayoshi, Araki, Eiichi   +21 more
core   +1 more source

SIRT6 and SIRT7 Target Identification Using Acyl-Nucleosomes [PDF]

, 2019
For eukaryotes, DNA is maintained in the form of chromatin, which is comprised of millions of repeated nucleosomes. Each nucleosome is assembled by wrapping 147 base pairs (bp) of DNA around a histone octamer containing 2 copies of H2A, H2B, H3 and H4 ...
Wang, Wei
core  

Endothelium-specific SIRT7 targeting ameliorates pulmonary hypertension through Krüpple-like factor 4 deacetylation. [PDF]

AIMS: Pulmonary hypertension (PH) is a pulmonary vascular disease characterized by a high mortality rate. Pulmonary arterial endothelium cells (PAECs) serve as a primary sensor of various environmental cues, such as shear stress and hypoxia, but PAEC ...
Wang, Jian, Liu, Baohua, Chen, Yuqin, Gou, Deming, Niu, Yanqin, Tang, Xiaolong, Yang, Qifeng, Shyy, John, Wei, Tong-You, Zhang, Jin, Wu, Xiaojing, Yan, Xiaosong, Yang, Lei, Xu, Chenzhong, Sun, Shimin, Yang, Langmei, Wang, Chen, Liu, Siqi   +17 more
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SIRT7 ameliorates Th17/Treg imbalance by desuccinylation of STAT3 to improve immune thrombocytopenia

Clinical & Translational Immunology
Objectives The imbalance of Th17/Treg cells represents a key pathogenic mechanism in immune thrombocytopenia (ITP); however, the underlying regulatory mechanisms remain poorly understood.
Jiao Ge, Xiaoyan Zhang, Fajuan Tang, Yan Liu   +3 more
doaj   +1 more source