Results 101 to 110 of about 7,699 (204)

Altered Sirtuin 7 Expression is Associated with Early Stage Breast Cancer

Breast Cancer: Basic and Clinical Research, 2015
Background To evaluate sirtuin-7 (SirT7) mRNA expression status in breast cancer patients with different metastatic stages and survey SirT7 mRNA expression status in eight different types of cancer.
Ahmad Aljada, Ayman M. Saleh, Moath Alkathiri, Heba Bani Shamsa, Ahmad Al-Bawab, Amre Nasr   +5 more
doaj   +1 more source

Electroacupuncture ameliorates vascular cognitive impairment through SIRT7‐mediated downregulation of H3K18 acetylation‐UBP1 in the hippocampus

Brain‐X, Volume 4, Issue 1, March 2026.
Electroacupuncture (EA) reduces H3K18ac enrichment at the Ubp1 promoter in the hippocampus in chronic cerebral hypoperfusion (CCH) rats by upregulating SIRT7‐mediated deacetylation, thereby suppressing the expression of UBP1. This EA‐dependent epigenetic regulation increases dendritic spine density and enhances long‐term potentiation, leading to ...
Wenju Wang, Sinuo Wang, Zhuoming Zheng, Yajun Cao, Mengquan Tan, Junzi Wang, Jiawei Jian, Yanyi Ding, Liming Chen, Zhongyi Hu, Yuxi Qiu, Changmei Lu, Yuwei Ye, Yangling Zheng, Yaling Dai, Siyuan Song, Minguang Yang, Weilin Liu   +17 more
wiley   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Natürlicher Verschleiß oder genetisches Programm? : Nicht alle Organismen altern [PDF]

, 2007
Ob das Alter ein Segen oder ein Fluch ist, darüber gehen seit der Antike die Meinungen auseinander, und es hat nicht an Versuchen gefehlt, für die doch unleugbaren Gebrechen und Gebresten die Gegenrechnung aufzumachen.
Prinzinger, Roland
core  

Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach [PDF]

, 2014
Posttranslational modifications (PTMs) play a crucial role in a wide range of biological processes. Lysine crotonylation (Kcr) is a newly discovered histone PTM that is enriched at active gene promoters and potential enhancers in mammalian cell genomes ...
Allfrey, Allfrey, Avalos, Collaborative Computational Project, Number 4, Dhalluin, Du, Feldman, Finnin, Goldberg, Grunstein, Haberland, Houtkooper, Hubbard, Imai, Iwahara, Jenuwein, Jiang, Jin, Kouzarides, Landry, Li, Li, Madsen, Marmorstein, Martin, Otwinowski, Peng, Roth, Sauve, Scher, Seet, Shechter, Shogren-Knaak, Tan, Tanner, Tanny, Taverna, Ura, Yang, Yang, Yuan, Zeng   +41 more
core   +2 more sources

Loss of Sirtuin 7 impairs cell motility and proliferation and enhances S-phase cell arrest after 5-fluorouracil treatment in head and neck cancer

Scientific Reports
Sirtuin 7 (SIRT7), a member of the sirtuin family of NAD+-dependent deacetylases, plays a vital role in cancer, exhibiting context-dependent functions across various malignancies.
Marta Halasa, Syeda Afshan, Anna Wawruszak, Agata Borkowska, Klaudia Brodaczewska, Alicja Przybyszewska-Podstawka, Joanna Kalafut, Marzena Baran, Adolfo Rivero-Müller, Andrzej Stepulak, Matthias Nees   +10 more
doaj   +1 more source

Analysis of Metabolic Characteristics of SIRT7 Low Expression Glioma Cell Line Using NMR-Based Metabonomics

Chinese Journal of Magnetic Resonance, 2019
Tumor is a metabolic disease. The effect of oncogene expression on the metabolism of cancer cells is one of the hotspots in cancer research. In this study, 1H NMR-based metabonomics analysis was used to explore the metabolic characteristics of glioma ...
SHAO Wei, LIN Qing-yuan, YANG Wen-sheng, HUANG Cai-hua, LIN Dong-hai   +4 more
doaj   +1 more source

The role of Micro-RNAs in Hepatocellular Carcinoma: From Molecular Biology to Treatment [PDF]

, 2014
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third leading cause of cancer deaths. microRNAs (miRNAs) are evolutionary conserved small non-coding RNA that negatively regulate gene expression and protein translation ...
Bianconi Maristella, Cascinu Stefano, D'Anzeo Marco, Del Prete Michela, Faloppi Luca, Giampieri Riccardo, SCARTOZZI, MARIO, Silvestris Nicola   +7 more
core   +1 more source

The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins [PDF]

, 2019
Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how cells do counteract spontaneous DNA–RNA hybrids, here we screen an siRNA library covering 240 human DNA damage response (DDR) genes ...
Aguilera López, Andrés, Barroso Ceballos, Sonia Inés, García Rubio, María Luisa, Gómez González, Belén, Herrera Moyano, Emilia, Muñoz Sánchez, Sergio   +5 more
core   +1 more source

Epigenetics and chromatin remodeling play a role in lung disease [PDF]

, 2011
Epigenetics is defined as heritable changes that affect gene expression without altering the DNA sequence. Epigenetic regulation of gene expression is facilitated through different mechanisms such as DNA methylation, histone modifications and RNA ...
Adcock, IM, Barnes, PJ, Masjedi, MR, Mortaz, E   +3 more
core   +1 more source