Results 121 to 130 of about 7,699 (204)
Acta Pharmacologica SinicaAcute kidney injury (AKI), triggered by various stimuli including ischemia-reperfusion, nephrotoxic insult, and sepsis, is characterized by an abrupt deterioration in kidney function. Ubiquitination is a post-translational modification of proteins that plays a critical role in the pathogenesis and progression of AKI.
Zhao, Ying +11 more
openaire +2 more sources
How Histone Deacetylases Control Myelination [PDF]
, 2018 Myelinated axons are a beautiful example of symbiotic interactions between two cell types: Myelinating glial cells organize axonal membranes and build their myelin sheaths to allow fast action potential conduction, while axons regulate myelination and ...
Jacob, Claire +2 more
core
, 2009 DNA-methylatie is een epigenetische modificatie. Dit type van modificaties verandert de genetische informatie zelf niet, maar wijzigt de laag erboven. Er worden chemische modificaties toegevoegd of gewijzigd op het DNA of de histonen (waarrond het DNA ...
Ongenaert, Maté
core +1 more source
The SIRT7-nucleolus connection in cancer
The nucleolar enzyme sirtuin 7 (SIRT7) promotes cancer progression in certain malignancies, likely in part by controlling ribosome biosynthesis. Recently, we discovered that SIRT7 destabilizes the cyclin dependent kinase inhibitor 2A (CDKN2A, known as ARF) within the nucleolus, aiding cancer progression. We propose that targeting nucleolar SIRT7 offers
Tarighi, S. +4 more
openaire +1 more source
SIRT7 as a context-dependent biomarker and therapeutic target: Insights from a pan-cancer study. [PDF]
PLoS OneIslam KMT, Mahmud S.
europepmc +1 more source
SIRT7 safeguards ERα proteostasis via deacetylation-dependent degradation of unliganded and misfolded receptors. [PDF]
J Biol ChemCao M +8 more
europepmc +1 more source