Results 111 to 120 of about 7,699 (204)

Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome. [PDF]

, 2017
Lysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modification is
Atger, F., Cantó, C., Collino, S., Da Silva, L., Dayon, L., Gachon, F., Kussmann, M., Martin, E., Martin, F.P., Mauvoisin, D., Montoliu, I., Naef, F., Núñez Galindo, A., Ratajczak, J., Wang, J.   +14 more
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Expression analysis, single nucleotide polymorphisms within SIRT4 and SIRT7 genes and their association with body size and meat quality traits in Qinchuan cattle

Journal of Integrative Agriculture, 2016
Silent information regulator 2 (Sir2) proteins, or sirtuins, are nicotine adenine dinucleotide (NAD)-dependent deacetylases that connect metabolism with longevity in lower organisms.
Lin-sheng GUI, Xiao-ling XIN, Jia-li WANG, Jie-yun HONG, Lin-sen ZAN   +4 more
doaj   +1 more source

A Novel Inhibitor Of Sirtuin: Elucidation Of Mode Of Action And Molecular Pathway In Colorectal Cancer Cell Line [PDF]

, 2017
Kanser kolon merupakan salah satu jenis kanser yang paling banyak didapati di seluruh dunia Colorectal cancer (CRC) is one of the most common types of cancer ...
Tan, Yi Jer
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YZL-51N functions as a selective inhibitor of SIRT7 by NAD+ competition to impede DNA damage repair

iScience
Summary: The NAD+-dependent deacetylase SIRT7 is a pivotal regulator of DNA damage response (DDR) and a promising drug target for developing cancer therapeutics. However, limited progress has been made in SIRT7 modulator discovery.
Tian-Shu Kang, Yong-Ming Yan, Yuan Tian, Jun Zhang, Minghui Zhang, Yuxin Shu, Jinbo Huang, Jing He, Cheng-Tian Tao, Qian Zhu, Jinke Gu, Xiaopeng Lu, Yong-Xian Cheng, Wei-Guo Zhu   +13 more
doaj   +1 more source

Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy

Cell Reports
Summary: Drug resistance significantly limits the efficacy of chemotherapy. The DNA mismatch repair (MMR) system maintains genomic stability by correcting DNA errors.
Lianhui Sun, Guangjian Fan, Zhuqing Zhang, Dong Chang, Xiaoyu Zhang, Tongqing Zhang, Jichuan Geng, Xiaoxia Zhang, Menghan Lin, Chen Hu, Jiaqi Zhou, Mengxue Wang, Liu Cao, Mary Zhang, Baokun He, Shengping Zhang, Chuangui Wang   +16 more
doaj   +1 more source

Dual role of Sirtuin 3 in carcinogenesis [PDF]

, 2019
Različiti oblici raka jedan od najčešćih uzroka smrtnosti širom svijeta, a s obzirom da mnogi terapeutici vremenom gube djelotvornost, potrebno je razviti nove strategije liječenja.
Ciganek, Ivan
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SIRT7 Inhibits Melanin Synthesis of PIG1 and PIG3V by Suppressing the Succinylation of EZR

Clinical, Cosmetic and Investigational Dermatology
Yuehong Ma, Hongqin Chang Department of Dermatology, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of ChinaCorrespondence: Hongqin Chang, Department of Dermatology, The Affiliated Changzhou ...
Ma Y, Chang H
doaj  

白内障患者の前房水中 Silent information regulator T1 [PDF]

, 2016
博士(医学) 乙第2915号(主論文の要旨、要約、審査結果の要旨、本文),著者名:Aki Kondo・Mari Goto・Tatsuya Mimura・Masao Matsubara,タイトル:Silent information regulator T1 in aqueous humor of patients with cataract,掲載誌:Clinical Ophthalmology(1177-5483),巻・頁・年:10巻p.307-312(2016),著作権関連情報:© 2016 ...
近藤 亜紀
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Mechanistic insights into SIRT7 and EZH2 regulation of cisplatin resistance in bladder cancer cells

Cell Death and Disease
Cisplatin (CDDP) resistance has been established to significantly impact Bladder Cancer (BCa) therapy. On the other hand, the crucial regulatory involvement of SIRT7 and EZH2 in bladder cancer development is well known.
Yudong Cao, Shuo Wang, Jinchao Ma, Mengping Long, Xiuli Ma, Xiao Yang, Yongpeng Ji, Xingxing Tang, Jia Liu, Chen Lin, Yong Yang, Peng Du   +11 more
doaj   +1 more source

Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells [PDF]

, 2019
Metastatic competence of cancer cells is influenced by many factors including metabolic alterations and changes in mitochondrial biogenesis and protein homeostasis.
Daverey, Amita, Hayward, Stephen, Khalimonchuk, Oleh, Kidambi, Srivatsan, Levytskyy, Roman M., Narasimhan, Madhusudhanan, Ponte Viana, Martonio, Stanke, Kimberly M., Swenson, Samantha   +8 more
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