Results 91 to 100 of about 6,075 (158)

SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1

Sirtuins are key players of metabolic stress response. Originally described as deacetylases, some sirtuins also exhibit poorly understood mono-adenosine 5'-diphosphate (ADP)-ribosyltransferase (mADPRT) activity.
Tischfield, J., Hurtado-Bagès, Sarah., Ianni, A., Serrano, L., Buschbeck, Marcus, Braun, T., de la Torre, Carolina, Morales-Sanfrutos, J., Simonet, Nicolas G., Vazquez Prat, Berta Nieves, Esteller, M., Sabidó, E., Vaquero, Alejandro, Universitat Autònoma de Barcelona, Thackray, J.K., Espinosa-Alcantud, María Dolores, Olivella, M.   +16 more
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SIRT7 Orchestrates Ligand‐Dependent ERα Signaling Rewiring to Drive Tamoxifen Resistance in ERα‐positive Breast Cancer

MedComm – Oncology
Tamoxifen resistance (TAMR) remains a major clinical challenge in the treatment of ERα‐positive breast cancer. Although ERα loss and activation of alternative survival pathways are well‐known contributors, the mechanisms underlying ERα dysregulation and ...
Yalan Wu, Huixia Liu, Ye Liu, Yanxue Mei, Mengdi Cao, Guo Li, Ronghui Fan, Junfeng Zhang, Langmei Yang, Jieling Liu, Qi Hou, Jinsong Li, Fujun Dai, Baohua Liu, Xiaolong Tang   +14 more
doaj   +1 more source

SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

, 2016
Although SIRT7 is a member of sirtuin family proteins that are described as NAD(+)-dependent class III histone deacetylases, the intrinsic enzymatic activity of this sirtuin protein remains to be investigated and the cellular function of SIRT7 remains to
Shi, Lan, Li, Wanjin, Yu, Wenhua, Yan, Ruorong, Cheng, Zhongyi, Yang, Shangda, He, Lin, Shang, Yongfeng, Liang, Jing, Sun, Luyang, Shi, Lei, Yang, Jianguo, Li, Lei, Zhang, Di, Yi, Xia   +14 more
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Comparative interactomes of SIRT6 and SIRT7: implication of functional links to aging

, 2018
Sirtuins are NAD(+)-dependent deacetylases that regulate a range of cellular processes. Although diverse functions of sirtuins have been proposed, those functions of SIRT6 and SIRT7 that are mediated by their interacting proteins remain elusive.
Lee, N, Park, SM, Kim, ES, Kwon, JH, Shin, J, Choi, KY, Kim, DK, Park, SJ, Moon, YH, Wang, HJ, Gho, YS   +10 more
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Role of SIRT7 in Prostate Cancer Progression: New Insight Into Potential Therapeutic Target

Cancer Medicine
Prostate cancer (PCa) is the second most common cancer in men worldwide, and understanding its molecular mechanisms is crucial for developing effective treatment strategies.
Jiale Zhang, Chenxin Liu, Wenting Luo, Baoqing Sun   +3 more
doaj   +1 more source

Regulation of macrophage function through cytoskeletal remodeling by Sirt7 and Miz1 [PDF]

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health challenge. Macrophages play a key role in controlling Mtb infection, yet Mtb can evade or disrupt their defenses.
Li, Fuxiang
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Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1

, 2017
Significance This paper describes a mechanism of regulation of Sirt1 activity by Sirt7. Deacetylases Sirt1 and Sirt7 belong to the mammalian family of seven sirtuins, which play important regulatory roles in several biological processes such as
Vaquero, A., Bober, E., Alejandro Vaquero, Nolte, H., Ianni, A., Kruger, M., Vakhrusheva, O., Braun, T., Olesya Vakhrusheva, Astrid Wietelmann, Nicolas G. Simonet, Fang, J., Simonet, N., Jian Fang, Thomas Braun, Hendrik Nolte, Smolka, C., Alessandro Ianni, Christian Smolka, Eva Bober, Juan M. Adrian-Segarra, Adrian-Segarra, J., Wietelmann, A., Marcus Krüger   +23 more
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SIRT7-mediated NRF2 deacetylation promotes antioxidant response and protects against chemodrug-induced liver injury

Cell Death and Disease
NRF2 has been recognized as a central hub that neutralizes ROS and restores intracellular redox balance. In addition to KEAP1 mediated ubiquitin-proteasome degradation, post-translational modifications of NRF2 are critical for regulating its nuclear ...
Tingzi Yu, Cong Ding, Jinying Peng, Gaoshuang Liang, Yongyi Tang, Jinqiu Zhao, Zhuan Li   +6 more
doaj   +1 more source

YZL-51N functions as a selective inhibitor of SIRT7 by NAD+ competition to impede DNA damage repair

iScience
Summary: The NAD+-dependent deacetylase SIRT7 is a pivotal regulator of DNA damage response (DDR) and a promising drug target for developing cancer therapeutics. However, limited progress has been made in SIRT7 modulator discovery.
Tian-Shu Kang, Yong-Ming Yan, Yuan Tian, Jun Zhang, Minghui Zhang, Yuxin Shu, Jinbo Huang, Jing He, Cheng-Tian Tao, Qian Zhu, Jinke Gu, Xiaopeng Lu, Yong-Xian Cheng, Wei-Guo Zhu   +13 more
doaj   +1 more source

Supplementary Figure 4 from Overexpression of Sirt7 Exhibits Oncogenic Property and Serves as a Prognostic Factor in Colorectal Cancer

, 2014
PDF file - 1464KB, Sirt7 mediates ERK1/2 activation and subsequent mitogenic effects.(A) real-time PCR analysis of Sirt7 in THC8307 cells after ectopic expression of different siRNA.
Xiaofang Ying (222066), Xiangqi Meng (222063), Yi Zhou (2723), Hui Wang (30400), Ran-yi Liu (14989712), Wenlin Huang (222075), Hongyan Yu (405816), Changchuan Pan (405817), Wen Ye (533818), Jiangxue Wu (222048)   +9 more
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