Results 71 to 80 of about 6,075 (158)

The histone deacetylase BpHST1 influences branch angle in white birch (Betula platyphylla)

The Plant Journal, Volume 127, Issue 5, September 2026.
SUMMARY Optimization of tree architecture is essential for advancing sustainable forestry, as appropriate canopy structure can contribute to growth and development. However, the molecular mechanisms that control tree architecture have not been fully characterized. While the putative NAD‐dependent histone deacetylase HST1 was shown to regulate branching
Lili Hou, Baoxin Li, Yueying Liu, Qingzhu Zhang, Zhimin Zheng   +4 more
wiley   +1 more source

Adaptation of White Adipocytes to Cooler Temperatures: Impacts on Energy Metabolism and Protein Acetylation

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Cultured white adipocytes exposed to 31°C undergo cell‐autonomous metabolic adaptation characterized by enhanced mitochondrial function and widespread remodeling of the mitochondrial acetylome. Acetyl‐proteomic and metabolomic profiling identified mitochondria‐associated proteins, including SHMT2 and PCCA, whose acetylation changes were linked to ...
Hiroyuki Mori, Hadla Hariri, William Moe, Sophia Durham, Yuridia Guzman, Emma Paulsson, Rachel C. Simmermon, Parth B. Bhanderi, Sydney K. Peterson, Mia J. Dickson, Charles R. Evans, Ormond A. MacDougald   +11 more
wiley   +1 more source

Insights into Cellular Stress Revealed by SIRT7 [PDF]

, 2014
Aging was once thought to be an inexorable process, driven by wear and tear that steadily accumulates in cells. However, we have now come to the realization that aging is subject to modulation by genetic pathways, including the insulin/IGF-1 pathway, the
Liu, Yufei
core   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, Volume 13, Issue 45, 13 August 2026.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, Volume 13, Issue 46, 17 August 2026.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

SMAD4 Expression and Its Association With Treatment Resistance and Clinical Outcomes in Oral Squamous Cell Carcinoma Treated With Preoperative Chemoradiotherapy

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Small mothers against decapentaplegic homologue 4 (SMAD4) plays an important role in transforming growth factor (TGF)‐β signaling and is associated with various cancers. However, little is known about SMAD4 expression in oral squamous cell carcinoma (OSCC).
Junki Sakata, Akiyuki Hirosue, Ryoji Yoshida, Yuichiro Matsuoka, Yusei Todoroki, Hidetaka Arita, Hikaru Nakashima, Tatsuro Yamamoto, Nozomu Takahashi, Masatoshi Hirayama, Kenta Kawahara, Ryo Toya, Ryuji Murakami, Takaaki Ito, Yoshikazu Kuwahara, Hideki Nakayama   +15 more
wiley   +1 more source

Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis

, 2017
Sirtuin 7 (SIRT7), a member of theNAD(+)-dependent class III histone deacetylases, is involved in the regulation of various cellular processes and in resisting various stresses, such as hypoxia, low glucose levels, and DNA damage. Interestingly, SIRT7 is
Yongcan Chen, Hui Wang, Xiong, Jiannan, Chen, Yongcan, Tang, Ming, Zhan, Junsi, Junsi Zhan, Fengjie Yuan, Wei-Guo Zhu, Wang, Haiying, Lu Jiang, Lu, Xiaopeng, Yuan, Fengjie, Jiannan Xiong, Ming Tang, Zhu, Wei-Guo, Cao, Ziyang, Ziyang Cao, Zhang, Chaohua, Xiaopeng Lu, Haiying Wang, Wang, Hui, Wang, Lina, Chaohua Zhang, Jiadong Wang, Jiang, Lu, Yinglu Li, Li, Yinglu, Lina Wang, Wang, Jiadong   +29 more
core   +1 more source

Altered Sirtuin 7 Expression is Associated with Early Stage Breast Cancer

Breast Cancer: Basic and Clinical Research, 2015
Background To evaluate sirtuin-7 (SirT7) mRNA expression status in breast cancer patients with different metastatic stages and survey SirT7 mRNA expression status in eight different types of cancer.
Ahmad Aljada, Ayman M. Saleh, Moath Alkathiri, Heba Bani Shamsa, Ahmad Al-Bawab, Amre Nasr   +5 more
doaj   +1 more source

SIRT7 : a novel molecular target for personalized cancer treatment? [PDF]

The Sirtuin family of NAD-dependent enzymes assumes a pivotal role in orchestrating adaptive responses to environmental fluctuations and stress stimuli, operating at both genomic and metabolic levels.
Vaquero, A., Braun, Thomas, Ianni, A., Tarighi, Shahriar, Braun, T., Ianni, Alessandro, Vaquero, Alejandro, Tarighi, S., Kumari, P., Kumari, Poonam   +9 more
core   +1 more source

Molecular, Cellular, and Physiological Characterization of Sirtuin 7 (SIRT7) [PDF]

, 2016
Sirtuin 7 (SIRT7), a histone 3 lysine 18 (H3K18) deacetylase, functions at chromatin to suppress endoplasmic reticulum (ER) stress and mitochondrial protein folding stress (PFS(mt)), and prevent the development of fatty liver disease and hematopoietic ...
Danica Chen, Jiyung Shin, Shin, Jiyung, Chen, Danica   +3 more
core   +1 more source