Cells, 2022 Sirtuins (SIRT1–7 in mammals) are evolutionarily conserved nicotinamide adenine dinucleotide-dependent lysine deacetylases/deacylases that regulate fundamental biological processes including aging.
Tomoya Mizumoto +10 more
doaj +1 more source
Tissue-Specific Orchestration of Gilthead Sea Bream Resilience to Hypoxia and High Stocking Density [PDF]
, 2019 Two different O-2 levels (normoxia: 75-85% O-2 saturation; moderate hypoxia: 42-43% O-2 saturation) and stocking densities (LD: 9.5, and HD: 19 kg/m(3)) were assessed on gilthead sea bream (Sparus aurata) in a 3-week feeding trial.
Ackerman +113 more
core +3 more sources
Sex-specific associations between particulate matter exposure and gene expression in independent discovery and validation cohorts of middle-aged men and women [PDF]
, 2017 BACKGROUND: Particulate matter (PM) exposure leads to premature death, mainly due to respiratory and cardiovascular diseases. OBJECTIVES: Identification of transcriptomic biomarkers of air pollution exposure and effect in a healthy adult population ...
Charlotte Vanpoucke +22 more
core +2 more sources
Sirt7 regulates circadian phase coherence of hepatic circadian clock via a body temperature/Hsp70-Sirt7-Cry1 axis [PDF]
, 2018 AbstractThe biological clock is generated in the hypothalamic suprachiasmatic nucleus (SCN), which synchronizes peripheral oscillators to coordinate physiological and behavioral activities throughout the body. Disturbance of circadian phase coherence between the central and peripheral could disrupt rhythms and thus cause diseases and aging.
Liu, Zuojun +10 more
openaire +1 more source
SIRT7 Is a Prognostic Biomarker Associated With Immune Infiltration in Luminal Breast Cancer
Frontiers in Oncology, 2020 Background: Sirtuin 7 (SIRT7), a protein-coding gene whose abnormal expression and function are associated with carcinogenesis. However, the prognosis of SIRT7 in different breast cancer subtypes and its correlation with tumor-infiltrating lymphocytes ...
Qin Huo +4 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2023 Melanoma is the most lethal type of skin cancer, originating from the malignant transformation of melanocyte. While the development of targeted therapy and immunotherapy has gained revolutionary advances in potentiating the therapeutic effect, the ...
Xiuli Yi +15 more
doaj +1 more source
SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1 [PDF]
Science Advances, 2020 SirT7 is a dual enzyme that regulates energy deprivation response through a functional interaction with histone variant mH2A1.
Nicolás G. Simonet +15 more
openaire +6 more sources
Genome-wide transcriptomics of aging in the rotifer Brachionus manjavacas, an emerging model system [PDF]
, 2017 © The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in BMC Genomics 18 (2017): 217, doi:10.1186/s12864-017-3540-x.Understanding gene expression changes over ...
Gribble, Kristin E. +1 more
core +2 more sources
Interaction and cross-talk between non-coding RNAs. [PDF]
, 2017 Non-coding RNA (ncRNA) has been shown to regulate diverse cellular processes and functions through controlling gene expression. Long non-coding RNAs (lncRNAs) act as a competing endogenous RNAs (ceRNAs) where microRNAs (miRNAs) and lncRNAs regulate each ...
Dahiya, Rajvir +3 more
core +2 more sources
Mechanism of desuccinylation of G6PD mediated by SIRT7 to promote vitiligo disease progression
Immunity, Inflammation and DiseaseBackground Sirtuin 7 (SIRT7) is pivotal in diverse diseases progression. Importantly, SIRT7 is associated with melanin production. However, whether SIRT7 regulates vitiligo is unclear.
Yiyun Yang +3 more
doaj +1 more source