Results 51 to 60 of about 6,075 (158)

SIRT7 facilitates ferroptosis resistance of melanocytes via activating the SMAD3-ATF3-GPX4 signaling pathway in vitiligo

Journal of Advanced Research
Introduction: Vitiligo is a hypopigmentation disorder characterized by epidermal melanocyte loss. Endogenous and exogenous oxidative stress causes the regulated cell death (RCD) of melanocytes in vitiligo.
Lili Wu, Weinan Guo, Hao Wang, Yuqi Yang, Hengxiang Zhang, Lin He, Jianru Chen, Kaiqiao He, Xinju Wang, Pan Kang, Jiaxi Chen, Linhan Jiang, Sen Guo, Yuqian Chang, Zhe Jian, Shuli Li, Yoshifumi Sato, Kazuya Yamagata, Tianwen Gao, Xiuli Yi, Chunying Li   +20 more
doaj   +1 more source

DataSheet1_Discovery of SIRT7 Inhibitor as New Therapeutic Options Against Liver Cancer.docx

, 2022
Optimal therapeutic strategies for liver cancer patients remain challenging due to the high recurrence rate after surgical resection and chemotherapy resistance.
Chen Zhang (66790), Yaqi Li (2936265), Zhuan Li (4244806), Bohao Liu (5436791), Chao Ning (1781215), Yimin Li (475612), Ying Wang (11406)   +6 more
core   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin, Yongcheng Chen, Yihao Xie, Dongyang Hu, Longhui Gong, Zhihua Chen, Linjie Chen, Minhao Gao, Qizhu Chen, Morgan Jones, Hui Wang, Xiuling You, Kenny Yat Hong Kwan, Shoutao Weng, Taidong Lyu, Xiang Chen, Yuxiao Zhu, Yusheng Wang, Bin Li, Xiangyang Wang, Xiaofeng Jia, Kailiang Zhou, Ouqiang Wu, Aimin Wu   +23 more
wiley   +1 more source

Monocyte SIRT7 and Cytokine Expression in Alcoholic Hepatitis [PDF]

, 2019
Background: Acute alcoholic hepatitis (AH) is a distinct form of alcoholic liver disease characterized by acute jaundice and hepatic and systemic inflammation. Heavy alcohol consumption is well-tolerated by most individuals.
Voss, Jordan Keith
core   +1 more source

Potent Activation of NAD⁺‑Dependent Deacetylase Sirt7 by Nucleosome Binding

, 2022
Sirtuin-7 (Sirt7) is a nuclear NAD+-dependent deacetylase with a broad spectrum of biological functions. Sirt7 overexpression is linked to several pathological states and enhances anticancer drug resistance, making the enzyme a promising target for the ...
Wallace H. Liu (2112604), John M. Denu (585630), Vyacheslav I. Kuznetsov (1886506), Mark A. Klein (3389282)   +3 more
core   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications

Portal Hypertension &Cirrhosis, EarlyView.
This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf, Mahboobeh Ebrahimi Varkiani, Saeid Abroun, Pedram Asadi‐Sarabi, Shukoofeh Torabi, Elham Rismani, Mohammad Majd Hammour, Andreas K. Nüssler, Massoud Vosough   +8 more
wiley   +1 more source

SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice

Cells, 2022
Sirtuins (SIRT1–7 in mammals) are evolutionarily conserved nicotinamide adenine dinucleotide-dependent lysine deacetylases/deacylases that regulate fundamental biological processes including aging.
Tomoya Mizumoto, Tatsuya Yoshizawa, Yoshifumi Sato, Takaaki Ito, Tomonori Tsuyama, Akiko Satoh, Satoshi Araki, Kenichi Tsujita, Masaru Tamura, Yuichi Oike, Kazuya Yamagata   +10 more
doaj   +1 more source

Epigenetic control of cellular plasticity in breast cancer progression

The FEBS Journal, EarlyView.
Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey, Elizabeth Podleszanski, William J. Muller   +2 more
wiley   +1 more source

SIRT7 modulates the stability and activity of the renal K-Cl cotransporter KCC4 through deacetylation

, 2021
SIRT7 is a NAD(+)-dependent deacetylase that controls important aspects of metabolism, cancer, and bone formation. However, the molecular targets and functions of SIRT7 in the kidney are currently unknown.
Laura A Velazquez‐Villegas, Doucet, Alain, López‐Barradas, Adriana M, Lilia G Noriega, Lorena Rojas‐Vega, María Castañeda‐Bueno, Auwerx, Johan, Rajaram, R.D., Castañeda-Bueno, M., Rajaram, Renuga D., Rojas-Vega, L., Gamba, G., Doucet, A., Mariana Sánchez‐Hernández, Johan Auwerx, Rojas‐Vega, Lorena, Adriana M López‐Barradas, Velazquez‐Villegas, Laura A, German Magaña‐Avila, Auwerx, J., Noriega, Lilia G., Tovar, Armando R, Castañeda‐Bueno, María, Velazquez-Villegas, Laura A., Ryu, Dongryeol, Staub, Olivier, Renuga D Rajaram, Anne Debonneville, Velazquez-Villegas, L.A., Tovar, A.R., Lopez-Barradas, Adriana M., Sánchez-Hernández, M., Adriana Mercado, Noriega, L.G., Olivier Staub, Magaña‐Avila, German, Mercado, A., Melo, Z., Torres, N., Dongryeol Ryu, Zesergio Melo, Gerardo Gamba, Debonneville, Anne, Staub, O., Melo, Zesergio, Reyes‐López, Yazmín, Lydie Cheval, Rojas-Vega, Lorena, Castaneda-Bueno, Maria, Noriega, Lilia G, Magana-Avila, German, Tovar, Armando R., Alain Doucet, Debonneville, A., Yazmín Reyes‐López, Sánchez‐Hernández, Mariana, Reyes-López, Y., Cheval, Lydie, Ryu, D., Mercado, Adriana, Magaña-Avila, G., Sanchez-Hernandez, Mariana, Armando R Tovar, Gamba, Gerardo, Rajaram, Renuga D, Nimbe Torres, Torres, Nimbe, López-Barradas, A.M., Reyes-Lopez, Yazmin, Cheval, L.   +69 more
core   +1 more source