SIRT7 Facilitates CENP-A Nucleosome Assembly and Suppresses Intestinal Tumorigenesis [PDF]
iScience, 2020 Summary: SIRT7 is a member of the mammalian sirtuins and functions as an NAD+-dependent deacylase. Here we show that SIRT7 deficiency leads to a lowered histone acetyltransferase 1 (HAT1) activity and therefore decreased histone H4K5 and H4K12 ...
Xiyang Liu +4 more
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SIRT7 regulates lipogenesis in adipocytes through deacetylation of PPARγ2 [PDF]
Journal of Diabetes Investigation, 2021 Aims/Introduction Peroxisome proliferator‐activated receptor (PPAR)‐γ2 is a transcription factor crucial for regulating adipogenesis and glucose/lipid metabolism, and synthetic PPARγ ligands, such as thiazolidinediones, are effective oral medication for ...
Fatema Akter +4 more
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Role of SIRT7 in Prostate Cancer Progression: New Insight Into Potential Therapeutic Target [PDF]
Cancer MedicineProstate cancer (PCa) is the second most common cancer in men worldwide, and understanding its molecular mechanisms is crucial for developing effective treatment strategies.
Jiale Zhang +3 more
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SIRT7 and p53 interaction in embryonic development and tumorigenesis
Frontiers in Cell and Developmental Biologyp53 is a hallmark tumor suppressor due in part to its role in cell cycle progression, DNA damage repair, and cellular apoptosis; its protein activity interrelates with the Sirtuin family of proteins, major regulators of the cellular response to metabolic,
Berta N. Vazquez +18 more
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SIRT7, H3K18ac, and ELK4 Immunohistochemical Expression in Hepatocellular Carcinoma [PDF]
Journal of Pathology and Translational Medicine, 2016 Background SIRT7 is one of the histone deacetylases and is NAD-dependent. It forms a complex with ETS-like transcription factor 4 (ELK4), which deacetylates H3K18ac and works as a transcriptional suppressor.
Hye Seung Lee +7 more
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SIRT7 affects the proliferation and apoptosis of papillary thyroid cancer cells by desuccinylation of LATS1 [PDF]
BMC CancerBackground Papillary thyroid cancer (PTC) is one of the malignant tumors with rapidly increasing morbidity and mortality. Sirtuin 7 (SIRT7) is a desuccinylase that is involved in tumorigenesis.
Qinghua Li, Gang Pu
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Regulation of Serine-Threonine Kinase Akt Activation by NAD+-Dependent Deacetylase SIRT7
Cell Reports, 2017 The Akt pathway is a central regulator that promotes cell survival in response to extracellular signals. Depletion of SIRT7, an NAD+-dependent deacetylase that is the least-studied sirtuin, is known to significantly increase Akt activity in mice through ...
Jia Yu, Bo Qin, Somaira Nowsheen
exaly +3 more sources
MedComm – OncologyTamoxifen resistance (TAMR) remains a major clinical challenge in the treatment of ERα‐positive breast cancer. Although ERα loss and activation of alternative survival pathways are well‐known contributors, the mechanisms underlying ERα dysregulation and ...
Yalan Wu +14 more
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SIRT7-mediated NRF2 deacetylation promotes antioxidant response and protects against chemodrug-induced liver injury [PDF]
Cell Death and DiseaseNRF2 has been recognized as a central hub that neutralizes ROS and restores intracellular redox balance. In addition to KEAP1 mediated ubiquitin-proteasome degradation, post-translational modifications of NRF2 are critical for regulating its nuclear ...
Tingzi Yu +6 more
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Protocol for high-throughput screening of SIRT7 inhibitors using fluorescent peptide technology [PDF]
STAR ProtocolsSummary: Fluorescent peptides combine the polypeptides with fluorescent groups organically to facilitate the measurement of enzyme activity. Here, we present a protocol to evaluate Sirtuin 7 (SIRT7) enzymatic activity by analyzing changes in luminescent ...
Tian-Shu Kang +4 more
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