Results 11 to 20 of about 6,075 (158)

SIRT7 and p53 interaction in embryonic development and tumorigenesis [PDF]

Frontiers in Cell and Developmental Biology
p53 is a hallmark tumor suppressor due in part to its role in cell cycle progression, DNA damage repair, and cellular apoptosis; its protein activity interrelates with the Sirtuin family of proteins, major regulators of the cellular response to metabolic,
Berta N. Vazquez, Berta N. Vazquez, Irene Fernández-Duran, Yurdiana Hernandez, Shahriar Tarighi, Joshua K. Thackray, Maria Espinosa-Alcantud, Poonam Kumari, Alessandro Ianni, Alessandro Ianni, Lionel Cesaire, Thomas Braun, Manel Esteller, Manel Esteller, Manel Esteller, Manel Esteller, Jay Tischfield, Alejandro Vaquero, Lourdes Serrano   +18 more
doaj   +6 more sources

The Emerging Role of SIRT7 in Glucose and Lipid Metabolism

Cells, 2023
Sirtuins (SIRT1–7 in mammals) are a family of NAD+-dependent lysine deacetylases and deacylases that regulate diverse biological processes, including metabolism, stress responses, and aging.
Kazuya Yamagata, Tomoya Mizumoto, Tatsuya Yoshizawa   +2 more
doaj   +2 more sources

SIRT7 Inhibits Melanin Synthesis of PIG1 and PIG3V by Suppressing the Succinylation of EZR [PDF]

Clinical, Cosmetic and Investigational Dermatology
Yuehong Ma, Hongqin Chang Department of Dermatology, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of ChinaCorrespondence: Hongqin Chang, Department of Dermatology, The Affiliated Changzhou ...
Ma Y, Chang H
doaj   +1 more source

SIRT7 inhibits cerebral ischemic injury by inhibiting microglia M1 polarization via desuccinylation of NAMPT

Brain Research Bulletin
Cerebral ischemic injury continues to be a leading cause of mortality and disability worldwide. Although Sirtuin 7 (SIRT7), a desuccinylase, is known to regulate protein expression, its role in cerebral ischemia remains unclear.
Ying Cheng, Kai Zhao, Jian Li, Qian Lei, Gang Zhang, Xiaoping Gao   +5 more
doaj   +2 more sources

SIRT7 affects the proliferation and apoptosis of papillary thyroid cancer cells by desuccinylation of LATS1

BMC Cancer
Background Papillary thyroid cancer (PTC) is one of the malignant tumors with rapidly increasing morbidity and mortality. Sirtuin 7 (SIRT7) is a desuccinylase that is involved in tumorigenesis.
Qinghua Li, Gang Pu
doaj   +2 more sources

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression [PDF]

Advanced Science
Pancreatic neuroendocrine tumors (PanNETs) frequently exhibit loss or reduced expression of the tumor suppressor MEN1, a key regulator of tumor progression and DNA damage response (DDR).
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
doaj   +2 more sources

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease [PDF]

Cell Reports, 2013
Nonalcoholic fatty liver disease is the most common chronic liver disorder in developed countries. Its pathogenesis is poorly understood, and therapeutic options are limited.
Jiyung Shin, Ming He, Yufei Liu, Silvana Paredes, Lidia Villanova, Katharine Brown, Xiaolei Qiu, Noushin Nabavi, Mary Mohrin, Kathleen Wojnoonski, Patrick Li, Hwei-Ling Cheng, Andrew J. Murphy, David M. Valenzuela, Hanzhi Luo, Pankaj Kapahi, Ronald Krauss, Raul Mostoslavsky, George D. Yancopoulos, Frederick W. Alt, Katrin F. Chua, Danica Chen   +21 more
doaj   +2 more sources

SIRT7 drives energy metabolic shifts in endometriosis via interaction with TUFM and Rhoa/Rock/Akt pathway activation [PDF]

Cellular and Molecular Life Sciences
Purpose Endometriosis is characterized by the ectopic growth of endometrial-like tissue outside the uterus and altered energy metabolism, but the specific mechanisms involved remain unclear. This study aimed to investigate the impact of Sirtuins7 (SIRT7)
Huaying Zhang, Jiahao Chen, Mengjie Yang, Xinyu Ding, Guolin Chai, Ruofan Huang, Dianchao Lin, Zhixiong Huang, Qionghua Chen   +8 more
doaj   +2 more sources

Regulation of Serine-Threonine Kinase Akt Activation by NAD+-Dependent Deacetylase SIRT7

Cell Reports, 2017
The Akt pathway is a central regulator that promotes cell survival in response to extracellular signals. Depletion of SIRT7, an NAD+-dependent deacetylase that is the least-studied sirtuin, is known to significantly increase Akt activity in mice through ...
Somaira Nowsheen, Jia Yu, Bo Qin
exaly   +3 more sources

Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy

Cell Reports
Summary: Drug resistance significantly limits the efficacy of chemotherapy. The DNA mismatch repair (MMR) system maintains genomic stability by correcting DNA errors.
Lianhui Sun, Guangjian Fan, Zhuqing Zhang, Dong Chang, Xiaoyu Zhang, Tongqing Zhang, Jichuan Geng, Xiaoxia Zhang, Menghan Lin, Chen Hu, Jiaqi Zhou, Mengxue Wang, Liu Cao, Mary Zhang, Baokun He, Shengping Zhang, Chuangui Wang   +16 more
doaj   +2 more sources