Results 71 to 80 of about 422,700 (297)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

ATP-dependent Remodeling of Chromatin

Cold Spring Harbor Symposia on Quantitative Biology, 1998
Peer ...
Wu, Carl, Tsukiyama, Toshio, Gdula, David, Georgel, Philippe, Martínez-Balbás, Marian, Mizuguchi, Gaku, Ossipow, Vincent, Sandaltzopoulos, Raphael, Wang, Hih M.   +8 more
openaire   +3 more sources

Chromatin remodelling comes into focus [PDF]

F1000Research, 2020
ATP-dependent chromatin remodelling enzymes are molecular machines that act to reconfigure the structure of nucleosomes. Until recently, little was known about the structure of these enzymes. Recent progress has revealed that their interaction with chromatin is dominated by ATPase domains that contact DNA at favoured locations on the nucleosome surface.
Ramasubramian Sundaramoorthy, Tom Owen-Hughes   +1 more
openaire   +3 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Inhibition of chromatin condensation disrupts planar cell migration

Nucleus
Cell migration involves the actin cytoskeleton, and recently recognized nuclear involvement. In this study, we explore the impact of chromatin remodeling on cell migration using NIH 3T3 cells and a scratch wound assay subjected to pharmacological ...
Jack Forman, Briar Hine, Samantha Kaonis, Soham Ghosh   +3 more
doaj   +1 more source

Global Regulatory DNA Potentiation by SMARCA4 Propagates to Selective Gene Expression Programs via Domain-Level Remodeling

Cell Reports, 2020
Summary: The human genome encodes millions of regulatory elements, of which only a small fraction are active within a given cell type. Little is known about the global impact of chromatin remodelers on regulatory DNA landscapes and how this translates to
John E. Lazar, Sandra Stehling-Sun, Vivek Nandakumar, Hao Wang, Daniel R. Chee, Nicholas P. Howard, Reyes Acosta, Douglass Dunn, Morgan Diegel, Fidencio Neri, Andres Castillo, Sean Ibarrientos, Kristen Lee, Ninnia Lescano, Ben Van Biber, Jemma Nelson, Jessica Halow, Richard Sandstrom, Daniel Bates, Fyodor D. Urnov, Alister P.W. Funnell, John A. Stamatoyannopoulos   +21 more
doaj   +1 more source

Snf2 family ATPases and DExx box helicases:differences and unifying concepts from high-resolution crystal structures [PDF]

, 2006
Proteins with sequence similarity to the yeast Snf2 protein form a large family of ATPases that act to alter the structure of a diverse range of DNA-protein structures including chromatin. Snf2 family enzymes are related in sequence to DExx box helicases,
Owen-Hughes, Tom; id_orcid, Flaus, Andrew, Hopfner, Karl-Peter, Dürr, Harald   +3 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Identification and characterization of FAM124B as a novel component of a CHD7 and CHD8 containing complex [PDF]

, 2012
BACKGROUND: Mutations in the chromodomain helicase DNA binding protein 7 gene (CHD7) lead to CHARGE syndrome, an autosomal dominant multiple malformation disorder. Proteins involved in chromatin remodeling typically act in multiprotein complexes.
Henning Urlaub, Schaefer, Inga-Marie, Silke Pauli (108935), Urlaub, Henning, Tamara I Rabe, Oellerich, Thomas, Yvonne Schulz, Inga-Marie Schaefer (108930), Pauli, Silke Jeannette, Wolf, Stephan, Batsukh, T., Schaefer , I., Henning Urlaub (22208), Thomas Oellerich, Rabe, T., Rabe, Tamara I., Tamara I. Rabe (108922), Pauli, Silke, Tserendulam Batsukh, Batsukh, Tserendulam, Inga-Marie Schaefer, Schulz, Y., Pauli, S., Yvonne Schulz (108919), Stephan Wolf (108920), Tserendulam Batsukh (108917), Urlaub, H., Stephan Wolf, Silke Pauli, Wolf, S., Oellerich, T., Schulz, Yvonne, Thomas Oellerich (108924)   +32 more
core   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source