Results 71 to 80 of about 680,917 (346)

Basis of specificity for a conserved and promiscuous chromatin remodeling protein

eLife, 2021
Eukaryotic genomes are organized dynamically through the repositioning of nucleosomes. Isw2 is an enzyme that has been previously defined as a genome-wide, nonspecific nucleosome spacing factor.
Drake A Donovan, Johnathan G Crandall, Vi N Truong, Abigail L Vaaler, Thomas B Bailey, Devin Dinwiddie, Orion GB Banks, Laura E McKnight, Jeffrey N McKnight   +8 more
doaj   +1 more source

Structural transition of the nucleosome during chromatin remodeling and transcription.

Current Opinion in Structural Biology, 2019
In eukaryotes, the nucleosome is the basic unit of chromatin. Since the genomic DNA is tightly wrapped around the histone octamer in the nucleosome, its function is severely restricted in chromatin.
W. Kobayashi, H. Kurumizaka
semanticscholar   +1 more source

A Double-Edged Role for SIRT7 in Cancer: Can Anti-Cancer Immunity Tip the Balance?

Pharmaceuticals
Background/Objectives: Sirtuin 7 (SIRT7), a nuclear NAD+-dependent deacylase, plays multifaceted and sometimes opposing roles in tumorigenesis. By preserving chromatin architecture and genome integrity, SIRT7 protects against malignant transformation ...
Shahriar Tarighi, Zifan Ning, Andrés Gámez-García, Alejandro Vaquero, Thomas Braun, Alessandro Ianni   +5 more
doaj   +1 more source

Chromatin Remodeling BAF (SWI/SNF) Complexes in Neural Development and Disorders

Frontiers in Molecular Neuroscience, 2017
The ATP-dependent BRG1/BRM associated factor (BAF) chromatin remodeling complexes are crucial in regulating gene expression by controlling chromatin dynamics.
G. Sokpor, Yuanbin Xie, Joachim Rosenbusch, Tran Tuoc   +3 more
semanticscholar   +1 more source

The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin Remodeling Complexes

Molecules and Cells, 2017
SUMMARY BET proteins commonly activate cellular gene expression, yet inhibiting their recruitment paradoxically reactivates latent HIV-1 transcription.
Ryan J. Conrad, P. Fozouni, Sean Thomas, Hendrik Sy, Qiang Zhang, Ming‐Ming Zhou, M. Ott   +6 more
semanticscholar   +1 more source

Molecular profiling of biliary tract cancers reveals distinct genomic landscapes between circulating and tissue tumor DNA

Experimental Hematology & Oncology
Biliary tract cancers (BTCs) are heterogeneous malignancies with dismal prognosis due to tumor aggressiveness and poor response to limited current therapeutic options.
Clémence Astier, Carine Ngo, Léo Colmet-Daage, Virginie Marty, Olivia Bawa, Claudio Nicotra, Maud Ngo-Camus, Antoine Italiano, Christophe Massard, Jean-Yves Scoazec, Cristina Smolenschi, Michel Ducreux, Antoine Hollebecque, Sophie Postel-Vinay   +13 more
doaj   +1 more source

The SIRT7-nucleolus connection in cancer: ARF enters the fray

Molecular & Cellular Oncology
The nucleolar enzyme sirtuin 7 (SIRT7) promotes cancer progression in certain malignancies, likely in part by controlling ribosome biosynthesis. Recently, we discovered that SIRT7 destabilizes the cyclin dependent kinase inhibitor 2A (CDKN2A, known as ...
Shahriar Tarighi, Poonam Kumari, Alejandro Vaquero, Thomas Braun, Alessandro Ianni   +4 more
doaj   +1 more source

ATP-dependent Remodeling of Chromatin

Cold Spring Harbor Symposia on Quantitative Biology, 1998
Peer ...
Wu, Carl, Tsukiyama, Toshio, Gdula, David, Georgel, Philippe, Martínez-Balbás, Marian, Mizuguchi, Gaku, Ossipow, Vincent, Sandaltzopoulos, Raphael, Wang, Hih M.   +8 more
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Global Regulatory DNA Potentiation by SMARCA4 Propagates to Selective Gene Expression Programs via Domain-Level Remodeling

Cell Reports, 2020
Summary: The human genome encodes millions of regulatory elements, of which only a small fraction are active within a given cell type. Little is known about the global impact of chromatin remodelers on regulatory DNA landscapes and how this translates to
John E. Lazar, Sandra Stehling-Sun, Vivek Nandakumar, Hao Wang, Daniel R. Chee, Nicholas P. Howard, Reyes Acosta, Douglass Dunn, Morgan Diegel, Fidencio Neri, Andres Castillo, Sean Ibarrientos, Kristen Lee, Ninnia Lescano, Ben Van Biber, Jemma Nelson, Jessica Halow, Richard Sandstrom, Daniel Bates, Fyodor D. Urnov, Alister P.W. Funnell, John A. Stamatoyannopoulos   +21 more
doaj   +1 more source